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Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week.
J Cardiovasc Pharmacol 2007; 49(2):74-80JC

Abstract

A single-dose ingestion of flavanol-rich cocoa acutely reverses endothelial dysfunction. To investigate the time course of endothelial function during daily consumption of high-flavanol cocoa, we determined flow-mediated dilation (FMD) acutely (for up to 6 hours after single-dose ingestion) and chronically (administration for 7 days). The study population represented individuals with smoking-related endothelial dysfunction; in addition to FMD, plasma nitrite and nitrate were measured. The daily consumption of a flavanol-rich cocoa drink (3 x 306 mg flavanols/d) over 7 days (n=6) resulted in continual FMD increases at baseline (after overnight fast and before flavanol ingestion) and in sustained FMD augmentation at 2 hours after ingestion. Fasted FMD responses increased from 3.7 +/- 0.4% on day 1 to 5.2 +/- 0.6%, 6.1 +/- 0.6%, and 6.6 +/- 0.5% (each P < 0.05) on days 3, 5, and 8, respectively. FMD returned to 3.3 +/- 0.3% after a washout week of cocoa-free diet (day 15). Increases observed in circulating nitrite, but not in circulating nitrate, paralleled the observed FMD augmentations. The acute, single-dose consumption of cocoa drinks with 28 to 918 mg of flavanols led to dose-dependent increases in FMD and nitrite, with a maximal FMD at 2 hours after consumption. The dose to achieve a half-maximal FMD response was 616 mg (n=6). Generally applied biomarkers for oxidative stress (plasma, MDA, TEAC) and antioxidant status (plasma ascorbate, urate) remained unaffected by cocoa flavanol ingestion. The daily consumption of flavanol-rich cocoa has the potential to reverse endothelial dysfunction in a sustained and dose-dependent manner.

Authors+Show Affiliations

Institute for Biochemistry and Molecular Biology I, Aachen, Germany. heissc@medicine.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17312446

Citation

Heiss, Christian, et al. "Sustained Increase in Flow-mediated Dilation After Daily Intake of High-flavanol Cocoa Drink Over 1 Week." Journal of Cardiovascular Pharmacology, vol. 49, no. 2, 2007, pp. 74-80.
Heiss C, Finis D, Kleinbongard P, et al. Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. J Cardiovasc Pharmacol. 2007;49(2):74-80.
Heiss, C., Finis, D., Kleinbongard, P., Hoffmann, A., Rassaf, T., Kelm, M., & Sies, H. (2007). Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. Journal of Cardiovascular Pharmacology, 49(2), pp. 74-80.
Heiss C, et al. Sustained Increase in Flow-mediated Dilation After Daily Intake of High-flavanol Cocoa Drink Over 1 Week. J Cardiovasc Pharmacol. 2007;49(2):74-80. PubMed PMID: 17312446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week. AU - Heiss,Christian, AU - Finis,David, AU - Kleinbongard,Petra, AU - Hoffmann,Arne, AU - Rassaf,Tienush, AU - Kelm,Malte, AU - Sies,Helmut, PY - 2007/2/22/pubmed PY - 2007/4/3/medline PY - 2007/2/22/entrez SP - 74 EP - 80 JF - Journal of cardiovascular pharmacology JO - J. Cardiovasc. Pharmacol. VL - 49 IS - 2 N2 - A single-dose ingestion of flavanol-rich cocoa acutely reverses endothelial dysfunction. To investigate the time course of endothelial function during daily consumption of high-flavanol cocoa, we determined flow-mediated dilation (FMD) acutely (for up to 6 hours after single-dose ingestion) and chronically (administration for 7 days). The study population represented individuals with smoking-related endothelial dysfunction; in addition to FMD, plasma nitrite and nitrate were measured. The daily consumption of a flavanol-rich cocoa drink (3 x 306 mg flavanols/d) over 7 days (n=6) resulted in continual FMD increases at baseline (after overnight fast and before flavanol ingestion) and in sustained FMD augmentation at 2 hours after ingestion. Fasted FMD responses increased from 3.7 +/- 0.4% on day 1 to 5.2 +/- 0.6%, 6.1 +/- 0.6%, and 6.6 +/- 0.5% (each P < 0.05) on days 3, 5, and 8, respectively. FMD returned to 3.3 +/- 0.3% after a washout week of cocoa-free diet (day 15). Increases observed in circulating nitrite, but not in circulating nitrate, paralleled the observed FMD augmentations. The acute, single-dose consumption of cocoa drinks with 28 to 918 mg of flavanols led to dose-dependent increases in FMD and nitrite, with a maximal FMD at 2 hours after consumption. The dose to achieve a half-maximal FMD response was 616 mg (n=6). Generally applied biomarkers for oxidative stress (plasma, MDA, TEAC) and antioxidant status (plasma ascorbate, urate) remained unaffected by cocoa flavanol ingestion. The daily consumption of flavanol-rich cocoa has the potential to reverse endothelial dysfunction in a sustained and dose-dependent manner. SN - 0160-2446 UR - https://www.unboundmedicine.com/medline/citation/17312446/Sustained_increase_in_flow_mediated_dilation_after_daily_intake_of_high_flavanol_cocoa_drink_over_1_week_ L2 - http://Insights.ovid.com/pubmed?pmid=17312446 DB - PRIME DP - Unbound Medicine ER -