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Pancreatic juice cytology and subclassification of intraductal papillary mucinous neoplasms of the pancreas.
Pancreas. 2007 Mar; 34(2):197-204.P

Abstract

OBJECTIVES

Histological subclassification of intraductal papillary mucinous neoplasms (IPMNs) is important because the malignant potential of each subtype is different. We investigated whether pancreatic juice cytology can be used to define the subtypes of IPMNs preoperatively.

METHODS

The cytological findings and pathological parameters in 19 cases of IPMN were analyzed for correlations. Pancreatic juice cytology specimens were reviewed and classified into 4 types according to the criteria previously described for histological diagnosis: intestinal (Int), gastric foveolar (GF), oncocytic (Onc), and pancreatobiliary (PB), and the resected IPMNs were classified histologically using the same criteria for comparison. Immunochemical testing for MUC proteins was also performed.

RESULTS

In 15 cases (79%), the cytological and histological subclassifications were in agreement. The cytology specimens displayed different features corresponded to their histological subtypes. The sensitivities of the cytological diagnosis of each subtype were 80.0% (Int), 72.7% (GF), and 100% (Onc/PB); and the specificities were 85.7% (Int), 87.5% (GF), and 93.8% (Onc/PB). The cytoplasm of the Int-type cells in the pancreatic juice cytology specimens was positive for MUC2.

CONCLUSIONS

Most of the cytological findings of IPMNs corresponded to the histological findings. The use of MUC2 immunocytochemistry in IPMN subtyping was also demonstrated. Subtyping of IPMNs is useful for preoperative evaluation in addition to cytomorphological grading.

Authors+Show Affiliations

The Third Department of Surgery, Tokyo Medical University, Nishi-shinjuku, Shinjuku-ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17312458

Citation

Hibi, Yasuhiro, et al. "Pancreatic Juice Cytology and Subclassification of Intraductal Papillary Mucinous Neoplasms of the Pancreas." Pancreas, vol. 34, no. 2, 2007, pp. 197-204.
Hibi Y, Fukushima N, Tsuchida A, et al. Pancreatic juice cytology and subclassification of intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2007;34(2):197-204.
Hibi, Y., Fukushima, N., Tsuchida, A., Sofuni, A., Itoi, T., Moriyasu, F., Mukai, K., & Aoki, T. (2007). Pancreatic juice cytology and subclassification of intraductal papillary mucinous neoplasms of the pancreas. Pancreas, 34(2), 197-204.
Hibi Y, et al. Pancreatic Juice Cytology and Subclassification of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Pancreas. 2007;34(2):197-204. PubMed PMID: 17312458.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic juice cytology and subclassification of intraductal papillary mucinous neoplasms of the pancreas. AU - Hibi,Yasuhiro, AU - Fukushima,Noriyoshi, AU - Tsuchida,Akihiko, AU - Sofuni,Atsushi, AU - Itoi,Takao, AU - Moriyasu,Fuminori, AU - Mukai,Kiyoshi, AU - Aoki,Tatsuya, PY - 2007/2/22/pubmed PY - 2007/3/27/medline PY - 2007/2/22/entrez SP - 197 EP - 204 JF - Pancreas JO - Pancreas VL - 34 IS - 2 N2 - OBJECTIVES: Histological subclassification of intraductal papillary mucinous neoplasms (IPMNs) is important because the malignant potential of each subtype is different. We investigated whether pancreatic juice cytology can be used to define the subtypes of IPMNs preoperatively. METHODS: The cytological findings and pathological parameters in 19 cases of IPMN were analyzed for correlations. Pancreatic juice cytology specimens were reviewed and classified into 4 types according to the criteria previously described for histological diagnosis: intestinal (Int), gastric foveolar (GF), oncocytic (Onc), and pancreatobiliary (PB), and the resected IPMNs were classified histologically using the same criteria for comparison. Immunochemical testing for MUC proteins was also performed. RESULTS: In 15 cases (79%), the cytological and histological subclassifications were in agreement. The cytology specimens displayed different features corresponded to their histological subtypes. The sensitivities of the cytological diagnosis of each subtype were 80.0% (Int), 72.7% (GF), and 100% (Onc/PB); and the specificities were 85.7% (Int), 87.5% (GF), and 93.8% (Onc/PB). The cytoplasm of the Int-type cells in the pancreatic juice cytology specimens was positive for MUC2. CONCLUSIONS: Most of the cytological findings of IPMNs corresponded to the histological findings. The use of MUC2 immunocytochemistry in IPMN subtyping was also demonstrated. Subtyping of IPMNs is useful for preoperative evaluation in addition to cytomorphological grading. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/17312458/Pancreatic_juice_cytology_and_subclassification_of_intraductal_papillary_mucinous_neoplasms_of_the_pancreas_ L2 - http://dx.doi.org/10.1097/MPA.0b013e31802dea0 DB - PRIME DP - Unbound Medicine ER -