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Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study.
Br J Nutr. 2007 Mar; 97(3):569-78.BJ

Abstract

Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.

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Authors+Show Affiliations

Hininger-Favier I
Laboratoire de Nurtition, Vieillissement et Maladies Cardiovasculaires (NVMC), La Tronche Cedex, France. Isabelle.Hininger@ujf-grenoble.fr
Andriollo-Sanchez M
No affiliation info available
Arnaud J
No affiliation info available
Meunier N
No affiliation info available
Bord S
No affiliation info available
Graham C
No affiliation info available
Polito A
No affiliation info available
Maiani G
No affiliation info available
O'Connor JM
No affiliation info available
Coudray C
No affiliation info available
Roussel AM
No affiliation info available

MeSH

Age FactorsAgedAged, 80 and overBody Mass IndexCopperDietary SupplementsDose-Response Relationship, DrugDouble-Blind MethodEnergy IntakeFemaleHumansLipid MetabolismMaleMiddle AgedSex FactorsTrace ElementsZinc

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17313720

Citation

Hininger-Favier, Isabelle, et al. "Age- and Sex-dependent Effects of Long-term Zinc Supplementation On Essential Trace Element Status and Lipid Metabolism in European Subjects: the Zenith Study." The British Journal of Nutrition, vol. 97, no. 3, 2007, pp. 569-78.
Hininger-Favier I, Andriollo-Sanchez M, Arnaud J, et al. Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. Br J Nutr. 2007;97(3):569-78.
Hininger-Favier, I., Andriollo-Sanchez, M., Arnaud, J., Meunier, N., Bord, S., Graham, C., Polito, A., Maiani, G., O'Connor, J. M., Coudray, C., & Roussel, A. M. (2007). Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. The British Journal of Nutrition, 97(3), 569-78.
Hininger-Favier I, et al. Age- and Sex-dependent Effects of Long-term Zinc Supplementation On Essential Trace Element Status and Lipid Metabolism in European Subjects: the Zenith Study. Br J Nutr. 2007;97(3):569-78. PubMed PMID: 17313720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. AU - Hininger-Favier,Isabelle, AU - Andriollo-Sanchez,Maud, AU - Arnaud,Josiane, AU - Meunier,Nathalie, AU - Bord,Séverine, AU - Graham,Ciaren, AU - Polito,Angela, AU - Maiani,Giuseppe, AU - O'Connor,Jacqueline M, AU - Coudray,Charles, AU - Roussel,Anne-Marie, PY - 2007/2/23/pubmed PY - 2007/4/11/medline PY - 2007/2/23/entrez SP - 569 EP - 78 JF - The British journal of nutrition JO - Br J Nutr VL - 97 IS - 3 N2 - Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55-70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age- and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17313720/Age__and_sex_dependent_effects_of_long_term_zinc_supplementation_on_essential_trace_element_status_and_lipid_metabolism_in_European_subjects:_the_Zenith_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507432974/type/journal_article DB - PRIME DP - Unbound Medicine ER -