Tags

Type your tag names separated by a space and hit enter

[Characterization of HIV-1 Gag-specific proliferative T cell responses in Chinese HIV-1 infected patients].
Zhonghua Yi Xue Za Zhi. 2006 Nov 28; 86(44):3099-103.ZY

Abstract

OBJECTIVE

To investigate the characteristics of HIV-1 Gag-specific T lymphocyte proliferative responses in Chinese HIV infected patients, analyze their associations with disease progression and explore the mechanism of the HIV-specific immune dysfunction in HIV infection.

METHODS

Specific proliferative responses of PBMC from thirty four HIV-1 infected patients to HIV-1 Gag antigen were detected by a BrdU incorporated flow cytometry intracellular stain, their relations with CD4(+) T cells absolute counts, plasma viral loads and CD8(+) T cell activate status were analyzed.

RESULTS

HIV-1 Gag-specific CD4(+) T cell proliferative responses of HIV-infected patients were significantly lower than that of healthy controls (P < 0.01), correlated inversely to CD38 expression on CD8(+) T lymphocytes and plasma viral loads (P < 0.05, P < 0.05), and directly to CD4(+) T cell absolute counts (P < 0.01). HIV-1 Gag-specific CD8(+) T cell proliferative responses of HIV-infected patients were significantly higher than that of healthy controls (P < 0.01), correlated directly to CD38 expression on CD8(+) T lymphocytes (P < 0.05), and inversely to CD4(+) T cell absolute counts (P < 0.01), but not correlated to viral loads (P > 0.05).

CONCLUSION

HIV-1 Gag-specific T cell proliferative response were abnormal in Chinese HIV-1 infected persons, HIV-1 Gag-specific CD4(+) T cell proliferative responses were decreased and their frequencies were closely correlated with disease progression.

Authors+Show Affiliations

Key Laboratory of Immunology of AIDS, Ministry of Health, the 1st Affiliated Hospital, China Medical University, Shenyang 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17313759

Citation

Wang, Qi, et al. "[Characterization of HIV-1 Gag-specific Proliferative T Cell Responses in Chinese HIV-1 Infected Patients]." Zhonghua Yi Xue Za Zhi, vol. 86, no. 44, 2006, pp. 3099-103.
Wang Q, Shang H, Wang YN, et al. [Characterization of HIV-1 Gag-specific proliferative T cell responses in Chinese HIV-1 infected patients]. Zhonghua Yi Xue Za Zhi. 2006;86(44):3099-103.
Wang, Q., Shang, H., Wang, Y. N., Zhang, Z. N., & Jiang, Y. J. (2006). [Characterization of HIV-1 Gag-specific proliferative T cell responses in Chinese HIV-1 infected patients]. Zhonghua Yi Xue Za Zhi, 86(44), 3099-103.
Wang Q, et al. [Characterization of HIV-1 Gag-specific Proliferative T Cell Responses in Chinese HIV-1 Infected Patients]. Zhonghua Yi Xue Za Zhi. 2006 Nov 28;86(44):3099-103. PubMed PMID: 17313759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Characterization of HIV-1 Gag-specific proliferative T cell responses in Chinese HIV-1 infected patients]. AU - Wang,Qi, AU - Shang,Hong, AU - Wang,Ya-nan, AU - Zhang,Zi-ning, AU - Jiang,Yong-jun, PY - 2007/2/23/pubmed PY - 2008/4/25/medline PY - 2007/2/23/entrez SP - 3099 EP - 103 JF - Zhonghua yi xue za zhi JO - Zhonghua Yi Xue Za Zhi VL - 86 IS - 44 N2 - OBJECTIVE: To investigate the characteristics of HIV-1 Gag-specific T lymphocyte proliferative responses in Chinese HIV infected patients, analyze their associations with disease progression and explore the mechanism of the HIV-specific immune dysfunction in HIV infection. METHODS: Specific proliferative responses of PBMC from thirty four HIV-1 infected patients to HIV-1 Gag antigen were detected by a BrdU incorporated flow cytometry intracellular stain, their relations with CD4(+) T cells absolute counts, plasma viral loads and CD8(+) T cell activate status were analyzed. RESULTS: HIV-1 Gag-specific CD4(+) T cell proliferative responses of HIV-infected patients were significantly lower than that of healthy controls (P < 0.01), correlated inversely to CD38 expression on CD8(+) T lymphocytes and plasma viral loads (P < 0.05, P < 0.05), and directly to CD4(+) T cell absolute counts (P < 0.01). HIV-1 Gag-specific CD8(+) T cell proliferative responses of HIV-infected patients were significantly higher than that of healthy controls (P < 0.01), correlated directly to CD38 expression on CD8(+) T lymphocytes (P < 0.05), and inversely to CD4(+) T cell absolute counts (P < 0.01), but not correlated to viral loads (P > 0.05). CONCLUSION: HIV-1 Gag-specific T cell proliferative response were abnormal in Chinese HIV-1 infected persons, HIV-1 Gag-specific CD4(+) T cell proliferative responses were decreased and their frequencies were closely correlated with disease progression. SN - 0376-2491 UR - https://www.unboundmedicine.com/medline/citation/17313759/[Characterization_of_HIV_1_Gag_specific_proliferative_T_cell_responses_in_Chinese_HIV_1_infected_patients]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0376-2491&amp;year=2006&amp;vol=86&amp;issue=44&amp;fpage=3099 DB - PRIME DP - Unbound Medicine ER -