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Study of traditional Chinese medicine volatile oils from different geographical origins by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS) in combination with multivariate analysis.
J Pharm Biomed Anal. 2007 Apr 11; 43(5):1721-7.JP

Abstract

Chemical constitutes of volatile oil in the rhizomes and radixes of Notopterygium incisum Ting ex H.T. chang (qianghuo in Chinese) from different regions were investigated using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-TOFMS) and GC x GC-flame ionization detector (FID). A total of 769 compounds were tentatively identified and quantified in a typical sample from Sichuan province, a producing area of the Genuine Medicinal Materials. An obvious group-type separation was observed in the GC x GC-TOFMS chromatogram. Identification and quantitative results showed that qianghuo from Sichuan province has some significant differences in the chemical composition from other geographical origin of herbs, especially in monoterpenes and oxygenated sesquiterpenes. The data of all individual peaks collected by GC x GC-FID were processed using a principal component analysis (PCA) method to classify the samples from different regions, find and identify the marker compounds that lead to the differentiation. The abundances of monoterpenes and oxygenated sesquiterpenes were responsible for the differentiation, which is in good agreement with the group quantitative results of GC x GC analysis.

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Authors+Show Affiliations

Qiu Y
National Chromatographic R & A Center, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China.
Lu X
No affiliation info available
Pang T
No affiliation info available
Zhu S
No affiliation info available
Kong H
No affiliation info available
Xu G
No affiliation info available

MeSH

ChinaFlame IonizationGas Chromatography-Mass SpectrometryGeographyMedicine, Chinese TraditionalMultivariate AnalysisOils, VolatilePlant RootsPrincipal Component AnalysisRhizome

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17314026

Citation

Qiu, Yaqiong, et al. "Study of Traditional Chinese Medicine Volatile Oils From Different Geographical Origins By Comprehensive Two-dimensional Gas Chromatography-time-of-flight Mass Spectrometry (GCxGC-TOFMS) in Combination With Multivariate Analysis." Journal of Pharmaceutical and Biomedical Analysis, vol. 43, no. 5, 2007, pp. 1721-7.
Qiu Y, Lu X, Pang T, et al. Study of traditional Chinese medicine volatile oils from different geographical origins by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS) in combination with multivariate analysis. J Pharm Biomed Anal. 2007;43(5):1721-7.
Qiu, Y., Lu, X., Pang, T., Zhu, S., Kong, H., & Xu, G. (2007). Study of traditional Chinese medicine volatile oils from different geographical origins by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS) in combination with multivariate analysis. Journal of Pharmaceutical and Biomedical Analysis, 43(5), 1721-7.
Qiu Y, et al. Study of Traditional Chinese Medicine Volatile Oils From Different Geographical Origins By Comprehensive Two-dimensional Gas Chromatography-time-of-flight Mass Spectrometry (GCxGC-TOFMS) in Combination With Multivariate Analysis. J Pharm Biomed Anal. 2007 Apr 11;43(5):1721-7. PubMed PMID: 17314026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of traditional Chinese medicine volatile oils from different geographical origins by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOFMS) in combination with multivariate analysis. AU - Qiu,Yaqiong, AU - Lu,Xin, AU - Pang,Tao, AU - Zhu,Shukui, AU - Kong,Hongwei, AU - Xu,Guowang, Y1 - 2007/01/16/ PY - 2006/11/15/received PY - 2006/12/23/revised PY - 2007/01/06/accepted PY - 2007/2/23/pubmed PY - 2007/6/19/medline PY - 2007/2/23/entrez SP - 1721 EP - 7 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 43 IS - 5 N2 - Chemical constitutes of volatile oil in the rhizomes and radixes of Notopterygium incisum Ting ex H.T. chang (qianghuo in Chinese) from different regions were investigated using comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC x GC-TOFMS) and GC x GC-flame ionization detector (FID). A total of 769 compounds were tentatively identified and quantified in a typical sample from Sichuan province, a producing area of the Genuine Medicinal Materials. An obvious group-type separation was observed in the GC x GC-TOFMS chromatogram. Identification and quantitative results showed that qianghuo from Sichuan province has some significant differences in the chemical composition from other geographical origin of herbs, especially in monoterpenes and oxygenated sesquiterpenes. The data of all individual peaks collected by GC x GC-FID were processed using a principal component analysis (PCA) method to classify the samples from different regions, find and identify the marker compounds that lead to the differentiation. The abundances of monoterpenes and oxygenated sesquiterpenes were responsible for the differentiation, which is in good agreement with the group quantitative results of GC x GC analysis. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/17314026/Study_of_traditional_Chinese_medicine_volatile_oils_from_different_geographical_origins_by_comprehensive_two_dimensional_gas_chromatography_time_of_flight_mass_spectrometry__GCxGC_TOFMS__in_combination_with_multivariate_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(07)00026-X DB - PRIME DP - Unbound Medicine ER -
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