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Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study.

Abstract

OBJECTIVE

To evaluate the association of meat and dairy food consumption with subsequent risk of prostate cancer.

METHODS

In 1989, 3,892 men 35+ years old, who participated in CLUE II study of Washington County, MD, completed an abbreviated Block food frequency questionnaire. Intake of meat and dairy related foods was calculated using consumption frequency and portion size. Incident prostate cancer cases (n = 199) were ascertained through October 2004. Cox proportional hazards regression was used to calculate hazard ratios (HR) of total and advanced (SEER states three and four; n = 54) prostate cancer and 95% confidence intervals (CI) adjusted for age, BMI at age 21, and intake of energy, saturated fat, and tomato products.

RESULTS

Intakes of total mean (HR = 0.90, 95% CI 0.60-1.33, comparing highest to lowest tertile) and red meat (HR = 0.87, 95% CI 0.59-1.32) were not statistically significantly associated with prostate cancer. However, processed meat consumption was associated with a non-statistically significant higher risk of total (5+ vs. < or =1 servings/week: HR = 2.24; 95% CI 0.90-5.59) prostate cancer. There was no association across tertiles of dairy or calcium with total prostate cancer, although compared tp < or =1 servings/week consumption of 5+ servings/week of dairy foods was associated with an increased risk of prostate cancer (HR = 1.65, 98% CI 1.02-2.66).

CONCLUSION

Overall, consumption of processed meat, but not total meat or red meat, was associated with a possible increased risk of total prostate cancer in this prospective study. Higher intake of dairy foods but not calcium was positively associated with prostate cancer. Further investigation into the mechanisms by which processed meat and dairy consumption might increase the risk of prostate cancer is suggested.

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Authors+Show Affiliations

,

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Rm. E 6138, Baltimore, MD 21205, USA.

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Source

Cancer causes & control : CCC 18:1 2007 Feb pg 41-50

MeSH

Adult
Calcium, Dietary
Cohort Studies
Dairy Products
Diet Surveys
Humans
Male
Meat Products
Prospective Studies
Prostatic Neoplasms
Risk Factors
Surveys and Questionnaires
United States

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17315319

Citation

Rohrmann, Sabine, et al. "Meat and Dairy Consumption and Subsequent Risk of Prostate Cancer in a US Cohort Study." Cancer Causes & Control : CCC, vol. 18, no. 1, 2007, pp. 41-50.
Rohrmann S, Platz EA, Kavanaugh CJ, et al. Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes Control. 2007;18(1):41-50.
Rohrmann, S., Platz, E. A., Kavanaugh, C. J., Thuita, L., Hoffman, S. C., & Helzlsouer, K. J. (2007). Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. Cancer Causes & Control : CCC, 18(1), pp. 41-50.
Rohrmann S, et al. Meat and Dairy Consumption and Subsequent Risk of Prostate Cancer in a US Cohort Study. Cancer Causes Control. 2007;18(1):41-50. PubMed PMID: 17315319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat and dairy consumption and subsequent risk of prostate cancer in a US cohort study. AU - Rohrmann,Sabine, AU - Platz,Elizabeth A, AU - Kavanaugh,Claudine J, AU - Thuita,Lucy, AU - Hoffman,Sandra C, AU - Helzlsouer,Kathy J, PY - 2007/2/23/pubmed PY - 2007/4/10/medline PY - 2007/2/23/entrez SP - 41 EP - 50 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 18 IS - 1 N2 - OBJECTIVE: To evaluate the association of meat and dairy food consumption with subsequent risk of prostate cancer. METHODS: In 1989, 3,892 men 35+ years old, who participated in CLUE II study of Washington County, MD, completed an abbreviated Block food frequency questionnaire. Intake of meat and dairy related foods was calculated using consumption frequency and portion size. Incident prostate cancer cases (n = 199) were ascertained through October 2004. Cox proportional hazards regression was used to calculate hazard ratios (HR) of total and advanced (SEER states three and four; n = 54) prostate cancer and 95% confidence intervals (CI) adjusted for age, BMI at age 21, and intake of energy, saturated fat, and tomato products. RESULTS: Intakes of total mean (HR = 0.90, 95% CI 0.60-1.33, comparing highest to lowest tertile) and red meat (HR = 0.87, 95% CI 0.59-1.32) were not statistically significantly associated with prostate cancer. However, processed meat consumption was associated with a non-statistically significant higher risk of total (5+ vs. < or =1 servings/week: HR = 2.24; 95% CI 0.90-5.59) prostate cancer. There was no association across tertiles of dairy or calcium with total prostate cancer, although compared tp < or =1 servings/week consumption of 5+ servings/week of dairy foods was associated with an increased risk of prostate cancer (HR = 1.65, 98% CI 1.02-2.66). CONCLUSION: Overall, consumption of processed meat, but not total meat or red meat, was associated with a possible increased risk of total prostate cancer in this prospective study. Higher intake of dairy foods but not calcium was positively associated with prostate cancer. Further investigation into the mechanisms by which processed meat and dairy consumption might increase the risk of prostate cancer is suggested. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17315319/Meat_and_dairy_consumption_and_subsequent_risk_of_prostate_cancer_in_a_US_cohort_study_ L2 - http://www.diseaseinfosearch.org/result/9175 DB - PRIME DP - Unbound Medicine ER -