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MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias.
J Neurol Sci. 2007 Jun 15; 257(1-2):97-104.JN

Abstract

OBJECTIVES

MRI assessments were correlated with serial Combined Mini-Mental Cognitive Capacity Screening Examinations (CMC). Vascular-MCI (VMCI), Neurodegenerative MCI (NMCI) and Parkinson-Lewy body MCI (PLB-MCI) were compared during conversions to dementia. Mild cognitive impairments (MCI) are identifiable prodromes for all dementia subtypes. MRI abnormalities are characterized among MCI subjects prodromal for dementia of Alzheimer's disease (DAT), vascular dementia (VaD) and Parkinson-Lewy body dementia (PLBD).

METHODS

Aging volunteers (n=166) were recruited from ongoing longitudinal studies of aging, stroke, cerebrovascular disease and dementia. Cognitively normal (CN, n=52), MCIs of neurodegenerative (N-MCI, n=30), vascular (V-MCI, n=35) and Parkinson-Lewy Body (PLB-MCI, n=8) subtypes, plus converted DAT (n=19), VaD (n=17) and PLBD (n=5) were all diagnosed according to established protocol recommendations. Cerebral MRI abnormalities were likewise intercorrelated utilizing quantitative volumetric measurements.

RESULTS

V-MCI and converted VaD showed extensive leukoaraiosis with more lacunar infarcts than subjects with N-MCI or PLB-MCI. N-MCI, prodromal for DAT, showed medial temporal atrophy, greater enlargement of temporal horns, and fewer vascular lesions. PLB-MCI, prodromal for PLBD, displayed third ventricular enlargement greater than N-MCI and V-MCI, with similar but less severe atrophy of medial temporal lobe than N-MCI and fewer vascular lesions than V-MCI. Cognitive Impairments due to PLB with vascular features (V-PLB-CI) showed more lacunar and microvascular lesions involving both white matter and basal ganglia with greater frontal horn enlargement.

CONCLUSIONS

This study confirms different MCI subtypes prior to conversion to different dementias listed, recognizable by specific MRI abnormalities.

Authors+Show Affiliations

Department of Neurology, Baylor College of Medicine, and Cerebrovascular Research Laboratories, Michael E. DeBakey Veterans Administration Medical Center, Houston, Texas 77098, USA. johnstirlingmeyer@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17316690

Citation

Meyer, John Stirling, et al. "MRI Confirms Mild Cognitive Impairments Prodromal for Alzheimer's, Vascular and Parkinson-Lewy Body Dementias." Journal of the Neurological Sciences, vol. 257, no. 1-2, 2007, pp. 97-104.
Meyer JS, Huang J, Chowdhury MH. MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias. J Neurol Sci. 2007;257(1-2):97-104.
Meyer, J. S., Huang, J., & Chowdhury, M. H. (2007). MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias. Journal of the Neurological Sciences, 257(1-2), 97-104.
Meyer JS, Huang J, Chowdhury MH. MRI Confirms Mild Cognitive Impairments Prodromal for Alzheimer's, Vascular and Parkinson-Lewy Body Dementias. J Neurol Sci. 2007 Jun 15;257(1-2):97-104. PubMed PMID: 17316690.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI confirms mild cognitive impairments prodromal for Alzheimer's, vascular and Parkinson-Lewy body dementias. AU - Meyer,John Stirling, AU - Huang,Juebin, AU - Chowdhury,Munir H, Y1 - 2007/02/21/ PY - 2007/2/24/pubmed PY - 2007/9/19/medline PY - 2007/2/24/entrez SP - 97 EP - 104 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 257 IS - 1-2 N2 - OBJECTIVES: MRI assessments were correlated with serial Combined Mini-Mental Cognitive Capacity Screening Examinations (CMC). Vascular-MCI (VMCI), Neurodegenerative MCI (NMCI) and Parkinson-Lewy body MCI (PLB-MCI) were compared during conversions to dementia. Mild cognitive impairments (MCI) are identifiable prodromes for all dementia subtypes. MRI abnormalities are characterized among MCI subjects prodromal for dementia of Alzheimer's disease (DAT), vascular dementia (VaD) and Parkinson-Lewy body dementia (PLBD). METHODS: Aging volunteers (n=166) were recruited from ongoing longitudinal studies of aging, stroke, cerebrovascular disease and dementia. Cognitively normal (CN, n=52), MCIs of neurodegenerative (N-MCI, n=30), vascular (V-MCI, n=35) and Parkinson-Lewy Body (PLB-MCI, n=8) subtypes, plus converted DAT (n=19), VaD (n=17) and PLBD (n=5) were all diagnosed according to established protocol recommendations. Cerebral MRI abnormalities were likewise intercorrelated utilizing quantitative volumetric measurements. RESULTS: V-MCI and converted VaD showed extensive leukoaraiosis with more lacunar infarcts than subjects with N-MCI or PLB-MCI. N-MCI, prodromal for DAT, showed medial temporal atrophy, greater enlargement of temporal horns, and fewer vascular lesions. PLB-MCI, prodromal for PLBD, displayed third ventricular enlargement greater than N-MCI and V-MCI, with similar but less severe atrophy of medial temporal lobe than N-MCI and fewer vascular lesions than V-MCI. Cognitive Impairments due to PLB with vascular features (V-PLB-CI) showed more lacunar and microvascular lesions involving both white matter and basal ganglia with greater frontal horn enlargement. CONCLUSIONS: This study confirms different MCI subtypes prior to conversion to different dementias listed, recognizable by specific MRI abnormalities. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17316690/MRI_confirms_mild_cognitive_impairments_prodromal_for_Alzheimer's_vascular_and_Parkinson_Lewy_body_dementias_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00039-1 DB - PRIME DP - Unbound Medicine ER -