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Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep.
Psychoneuroendocrinology. 2007 Apr; 32(3):287-92.P

Abstract

Ghrelin and growth hormone (GH) releasing hormone (GHRH) both stimulate GH secretion and slow wave sleep (SWS), whereas ghrelin increases, and GHRH decreases cortisol in males. However, GHRH's effect on sleep and cortisol was abolished, on GH mitigated, when administered in the early morning, possibly due to counteracting corticotropin releasing hormone (CRH). Aim of this study was to investigate ghrelin's influence on sleep, GH and cortisol when administered in the early morning. Nocturnal (2000-1000 h) GH and cortisol patterns and polysomnography (2300-1000 h) were determined in 12 healthy males (25.3+/-3.2 yr) twice, receiving 50 microg ghrelin or placebo at 0400, 0500, 0600, and 0700 h, in this single-blind, randomized, cross-over study. The first ghrelin bolus caused the strongest (38.7+/-6.5 ng/ml, placebo: 0.4+/-1.1 ng/ml), second and third smaller, the fourth no GH peak. GH levels remained significantly (p<0.05) higher from 0420-0740 h in the ghrelin condition. Comparably, the first ghrelin bolus caused the strongest cortisol response (156.0+/-12.6 ng/ml; placebo: 78.0+/-10.5 ng/ml). Cortisol was significantly higher from 0440 to 0540 and at 0720 h and decreased thereafter to significantly lower levels (0820-0840 h). Sleep variables did not differ in both conditions. In contrast to GHRH, ghrelin's stimulatory effects were apparently not counteracted (GH), and enhanced (cortisol), respectively, by high CRH in the second half of night.

Authors+Show Affiliations

Max-Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. kluge@mpipsykl.mpg.de <kluge@mpipsykl.mpg.de>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17317021

Citation

Kluge, Michael, et al. "Ghrelin Administered in the Early Morning Increases Secretion of Cortisol and Growth Hormone Without Affecting Sleep." Psychoneuroendocrinology, vol. 32, no. 3, 2007, pp. 287-92.
Kluge M, Schüssler P, Zuber V, et al. Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology. 2007;32(3):287-92.
Kluge, M., Schüssler, P., Zuber, V., Yassouridis, A., & Steiger, A. (2007). Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. Psychoneuroendocrinology, 32(3), 287-92.
Kluge M, et al. Ghrelin Administered in the Early Morning Increases Secretion of Cortisol and Growth Hormone Without Affecting Sleep. Psychoneuroendocrinology. 2007;32(3):287-92. PubMed PMID: 17317021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep. AU - Kluge,Michael, AU - Schüssler,Petra, AU - Zuber,Verena, AU - Yassouridis,Alexander, AU - Steiger,Axel, Y1 - 2007/02/20/ PY - 2006/10/24/received PY - 2006/12/22/revised PY - 2006/12/29/accepted PY - 2007/2/24/pubmed PY - 2007/6/6/medline PY - 2007/2/24/entrez SP - 287 EP - 92 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 32 IS - 3 N2 - Ghrelin and growth hormone (GH) releasing hormone (GHRH) both stimulate GH secretion and slow wave sleep (SWS), whereas ghrelin increases, and GHRH decreases cortisol in males. However, GHRH's effect on sleep and cortisol was abolished, on GH mitigated, when administered in the early morning, possibly due to counteracting corticotropin releasing hormone (CRH). Aim of this study was to investigate ghrelin's influence on sleep, GH and cortisol when administered in the early morning. Nocturnal (2000-1000 h) GH and cortisol patterns and polysomnography (2300-1000 h) were determined in 12 healthy males (25.3+/-3.2 yr) twice, receiving 50 microg ghrelin or placebo at 0400, 0500, 0600, and 0700 h, in this single-blind, randomized, cross-over study. The first ghrelin bolus caused the strongest (38.7+/-6.5 ng/ml, placebo: 0.4+/-1.1 ng/ml), second and third smaller, the fourth no GH peak. GH levels remained significantly (p<0.05) higher from 0420-0740 h in the ghrelin condition. Comparably, the first ghrelin bolus caused the strongest cortisol response (156.0+/-12.6 ng/ml; placebo: 78.0+/-10.5 ng/ml). Cortisol was significantly higher from 0440 to 0540 and at 0720 h and decreased thereafter to significantly lower levels (0820-0840 h). Sleep variables did not differ in both conditions. In contrast to GHRH, ghrelin's stimulatory effects were apparently not counteracted (GH), and enhanced (cortisol), respectively, by high CRH in the second half of night. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/17317021/Ghrelin_administered_in_the_early_morning_increases_secretion_of_cortisol_and_growth_hormone_without_affecting_sleep_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(07)00011-X DB - PRIME DP - Unbound Medicine ER -