Tags

Type your tag names separated by a space and hit enter

Impact of chronic obstructive pulmonary disease on post-myocardial infarction outcomes.
Am J Cardiol 2007; 99(5):636-41AJ

Abstract

Although chronic obstructive pulmonary disease (COPD) is common in patients with myocardial infarction (MI), its association with long-term mortality after MI is controversial and little is known about its influence on patients' health status (symptoms, function, and quality of life). We prospectively enrolled 2,481 patients presenting with MI at 19 United States centers to examine the relations between COPD and patients' long-term mortality, rehospitalization rates, and health status after MI. Patients were administered the disease-specific Seattle Angina Questionnaire and the generic Short Form 12 at baseline and 1 year later. COPD was common (15.6% of patients) and was associated with a substantially greater risk of 1-year mortality (15.8% vs 5.7%, p <0.001) and rehospitalization (48.7% vs 38.6%, p <0.001). After extensive adjustment for baseline differences, patients with COPD had a twofold greater 1-year mortality rate (hazard ratio 2.00, 95% confidence interval [CI] 1.44 to 2.79) and higher rehospitalization rates (hazard ratio 1.22, 95% CI 1.01 to 1.48). Similarly, adjusted 1-year health status was worse in patients with COPD, with lower 1-year Seattle Angina Questionnaire quality-of-life score (-2.53 points, 95% CI -0.25 to -4.81) and Short Form 12 physical component score (-1.83 points, 95% CI -0.43 to -3.24). In addition, COPD was associated with a trend toward a greater prevalence of angina at 1 year (risk ratio 1.12, 95% CI 0.89 to 1.41). In conclusion, patients with COPD have greater mortality, higher rehospitalization rates, and poorer health status 1 year after a MI. Although additional research is needed, clinicians should recognize that patients with COPD are at high risk for poor outcomes after MI.

Authors+Show Affiliations

Mayo Graduate School of Medicine, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17317363

Citation

Salisbury, Adam C., et al. "Impact of Chronic Obstructive Pulmonary Disease On Post-myocardial Infarction Outcomes." The American Journal of Cardiology, vol. 99, no. 5, 2007, pp. 636-41.
Salisbury AC, Reid KJ, Spertus JA. Impact of chronic obstructive pulmonary disease on post-myocardial infarction outcomes. Am J Cardiol. 2007;99(5):636-41.
Salisbury, A. C., Reid, K. J., & Spertus, J. A. (2007). Impact of chronic obstructive pulmonary disease on post-myocardial infarction outcomes. The American Journal of Cardiology, 99(5), pp. 636-41.
Salisbury AC, Reid KJ, Spertus JA. Impact of Chronic Obstructive Pulmonary Disease On Post-myocardial Infarction Outcomes. Am J Cardiol. 2007 Mar 1;99(5):636-41. PubMed PMID: 17317363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of chronic obstructive pulmonary disease on post-myocardial infarction outcomes. AU - Salisbury,Adam C, AU - Reid,Kimberly J, AU - Spertus,John A, Y1 - 2007/01/09/ PY - 2006/06/07/received PY - 2006/09/28/revised PY - 2006/09/28/accepted PY - 2007/2/24/pubmed PY - 2007/4/11/medline PY - 2007/2/24/entrez SP - 636 EP - 41 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 99 IS - 5 N2 - Although chronic obstructive pulmonary disease (COPD) is common in patients with myocardial infarction (MI), its association with long-term mortality after MI is controversial and little is known about its influence on patients' health status (symptoms, function, and quality of life). We prospectively enrolled 2,481 patients presenting with MI at 19 United States centers to examine the relations between COPD and patients' long-term mortality, rehospitalization rates, and health status after MI. Patients were administered the disease-specific Seattle Angina Questionnaire and the generic Short Form 12 at baseline and 1 year later. COPD was common (15.6% of patients) and was associated with a substantially greater risk of 1-year mortality (15.8% vs 5.7%, p <0.001) and rehospitalization (48.7% vs 38.6%, p <0.001). After extensive adjustment for baseline differences, patients with COPD had a twofold greater 1-year mortality rate (hazard ratio 2.00, 95% confidence interval [CI] 1.44 to 2.79) and higher rehospitalization rates (hazard ratio 1.22, 95% CI 1.01 to 1.48). Similarly, adjusted 1-year health status was worse in patients with COPD, with lower 1-year Seattle Angina Questionnaire quality-of-life score (-2.53 points, 95% CI -0.25 to -4.81) and Short Form 12 physical component score (-1.83 points, 95% CI -0.43 to -3.24). In addition, COPD was associated with a trend toward a greater prevalence of angina at 1 year (risk ratio 1.12, 95% CI 0.89 to 1.41). In conclusion, patients with COPD have greater mortality, higher rehospitalization rates, and poorer health status 1 year after a MI. Although additional research is needed, clinicians should recognize that patients with COPD are at high risk for poor outcomes after MI. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17317363/Impact_of_chronic_obstructive_pulmonary_disease_on_post_myocardial_infarction_outcomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(06)02266-1 DB - PRIME DP - Unbound Medicine ER -