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Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity.
Med Microbiol Immunol. 2007 Sep; 196(3):165-70.MM

Abstract

We try to find the association of cytomegalovirus (CMV) infection and anti-beta2 glycoprotein 1 autoantibodies (anti-beta2 GP1), a key antibody in antiphospholipid syndrome (APS), among systemic lupus erythematosus (SLE) and cerebral vascular accident (CVA) patients. This retrospective study enrolled serum samples obtained from 87 SLE and 97 CVA patients who have been checked for the existence of anti-beta2 GP1. First, the prevalence rate of anti-CMV IgG and IgM in patients with and without anti-beta2 GP1 were compared. Second, the prevalence of anti-CMV IgG and IgM were compared between SLE and CVA patients. Last, this study analyzed the clinical characteristics and disease activity in SLE patients with positive anti-CMV IgM and IgG. No difference existed in the prevalence rate of anti-CMV IgG and IgM between positive or negative anti-beta2 GP1 serum samples in both SLE and CVA patients. However, the prevalence of anti-CMV IgM was significantly higher in the SLE group than in the CVA group. Severity of clinical features and SLEDAI scores were considerably higher in patients with positive anti-CMV IgM than in SLE patients with negative anti-CMV IgM. Very impressively, all IgM-positive SLE samples (9/9) carrying highest levels of anti-CMV IgG, indicated reactivation of the latent CMV infection. Hence, it suggests that CMV reactivation might contribute toward the disease flare in some SLE patients. In future, a prospective and longitudinal study is stongly indicated.

Authors+Show Affiliations

Division of Allergy, Immuology and Rheumatology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, No.123, Ta-Pei Road, Niao-Sung Hsiang, 833 Kaohsiung Hsein, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17318574

Citation

Su, Ben Yu-Jih, et al. "Incidental Discovery of High Systemic Lupus Erythematosus Disease Activity Associated With Cytomegalovirus Viral Activity." Medical Microbiology and Immunology, vol. 196, no. 3, 2007, pp. 165-70.
Su BY, Su CY, Yu SF, et al. Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity. Med Microbiol Immunol. 2007;196(3):165-70.
Su, B. Y., Su, C. Y., Yu, S. F., & Chen, C. J. (2007). Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity. Medical Microbiology and Immunology, 196(3), 165-70.
Su BY, et al. Incidental Discovery of High Systemic Lupus Erythematosus Disease Activity Associated With Cytomegalovirus Viral Activity. Med Microbiol Immunol. 2007;196(3):165-70. PubMed PMID: 17318574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidental discovery of high systemic lupus erythematosus disease activity associated with cytomegalovirus viral activity. AU - Su,Ben Yu-Jih, AU - Su,Cheng-Yu, AU - Yu,Shan-Fu, AU - Chen,Chung-Jen, Y1 - 2007/02/23/ PY - 2006/10/05/received PY - 2007/2/24/pubmed PY - 2008/9/26/medline PY - 2007/2/24/entrez SP - 165 EP - 70 JF - Medical microbiology and immunology JO - Med Microbiol Immunol VL - 196 IS - 3 N2 - We try to find the association of cytomegalovirus (CMV) infection and anti-beta2 glycoprotein 1 autoantibodies (anti-beta2 GP1), a key antibody in antiphospholipid syndrome (APS), among systemic lupus erythematosus (SLE) and cerebral vascular accident (CVA) patients. This retrospective study enrolled serum samples obtained from 87 SLE and 97 CVA patients who have been checked for the existence of anti-beta2 GP1. First, the prevalence rate of anti-CMV IgG and IgM in patients with and without anti-beta2 GP1 were compared. Second, the prevalence of anti-CMV IgG and IgM were compared between SLE and CVA patients. Last, this study analyzed the clinical characteristics and disease activity in SLE patients with positive anti-CMV IgM and IgG. No difference existed in the prevalence rate of anti-CMV IgG and IgM between positive or negative anti-beta2 GP1 serum samples in both SLE and CVA patients. However, the prevalence of anti-CMV IgM was significantly higher in the SLE group than in the CVA group. Severity of clinical features and SLEDAI scores were considerably higher in patients with positive anti-CMV IgM than in SLE patients with negative anti-CMV IgM. Very impressively, all IgM-positive SLE samples (9/9) carrying highest levels of anti-CMV IgG, indicated reactivation of the latent CMV infection. Hence, it suggests that CMV reactivation might contribute toward the disease flare in some SLE patients. In future, a prospective and longitudinal study is stongly indicated. SN - 0300-8584 UR - https://www.unboundmedicine.com/medline/citation/17318574/Incidental_discovery_of_high_systemic_lupus_erythematosus_disease_activity_associated_with_cytomegalovirus_viral_activity_ L2 - https://dx.doi.org/10.1007/s00430-007-0040-7 DB - PRIME DP - Unbound Medicine ER -