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Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study.
Osteoporos Int. 2007 May; 18(5):593-602.OI

Abstract

INTRODUCTION

Previous studies have found inconsistent relationships of alcohol consumption with risk of hip fracture, and the importance of bone mineral density and risk of falls in mediating such a relationship has not been determined.

METHODS

As part of the Cardiovascular Health Study, a population-based cohort study of adults aged 65 years and older from four U.S. communities, 5,865 participants reported their use of beer, wine, and liquor yearly. We identified cases of hip fracture unrelated to malignancy or motor vehicle accidents using hospitalization discharge diagnoses. A subgroup of 1,567 participants in two communities underwent dual-energy x-ray absorptiometry scans to assess bone mineral density.

RESULTS

A total of 412 cases of hip fracture occurred during an average of 12 years of follow-up. There was a significant U-shaped relationship between alcohol intake and risk of hip fracture (p quadratic 0.02). Compared with long-term abstainers, the adjusted hazard ratios for hip fracture were 0.78 (95% confidence interval [CI], 0.61-1.00) among consumers of up to 14 drinks per week and 1.18 (95% CI, 0.77-1.81) among consumers of 14 or more drinks per week. Alcohol intake was associated with bone mineral density of the total hip and femoral neck in a stepwise manner, with approximately 5% (95% CI, 1%-9%) higher bone density among consumers of 14 or more drinks per week than among abstainers. These relationships were all similar among men and women.

CONCLUSIONS

Among older adults, moderate alcohol consumption has a U-shaped relationship with risk of hip fracture, but a graded positive relationship with bone mineral density at the hip.

Authors+Show Affiliations

Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02446, USA. kmukamal@bidmc.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17318666

Citation

Mukamal, K J., et al. "Alcohol Consumption, Bone Density, and Hip Fracture Among Older Adults: the Cardiovascular Health Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 18, no. 5, 2007, pp. 593-602.
Mukamal KJ, Robbins JA, Cauley JA, et al. Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study. Osteoporos Int. 2007;18(5):593-602.
Mukamal, K. J., Robbins, J. A., Cauley, J. A., Kern, L. M., & Siscovick, D. S. (2007). Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 18(5), 593-602.
Mukamal KJ, et al. Alcohol Consumption, Bone Density, and Hip Fracture Among Older Adults: the Cardiovascular Health Study. Osteoporos Int. 2007;18(5):593-602. PubMed PMID: 17318666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption, bone density, and hip fracture among older adults: the cardiovascular health study. AU - Mukamal,K J, AU - Robbins,J A, AU - Cauley,J A, AU - Kern,L M, AU - Siscovick,D S, Y1 - 2007/02/21/ PY - 2006/08/30/received PY - 2006/10/30/accepted PY - 2007/2/24/pubmed PY - 2007/6/1/medline PY - 2007/2/24/entrez SP - 593 EP - 602 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 18 IS - 5 N2 - INTRODUCTION: Previous studies have found inconsistent relationships of alcohol consumption with risk of hip fracture, and the importance of bone mineral density and risk of falls in mediating such a relationship has not been determined. METHODS: As part of the Cardiovascular Health Study, a population-based cohort study of adults aged 65 years and older from four U.S. communities, 5,865 participants reported their use of beer, wine, and liquor yearly. We identified cases of hip fracture unrelated to malignancy or motor vehicle accidents using hospitalization discharge diagnoses. A subgroup of 1,567 participants in two communities underwent dual-energy x-ray absorptiometry scans to assess bone mineral density. RESULTS: A total of 412 cases of hip fracture occurred during an average of 12 years of follow-up. There was a significant U-shaped relationship between alcohol intake and risk of hip fracture (p quadratic 0.02). Compared with long-term abstainers, the adjusted hazard ratios for hip fracture were 0.78 (95% confidence interval [CI], 0.61-1.00) among consumers of up to 14 drinks per week and 1.18 (95% CI, 0.77-1.81) among consumers of 14 or more drinks per week. Alcohol intake was associated with bone mineral density of the total hip and femoral neck in a stepwise manner, with approximately 5% (95% CI, 1%-9%) higher bone density among consumers of 14 or more drinks per week than among abstainers. These relationships were all similar among men and women. CONCLUSIONS: Among older adults, moderate alcohol consumption has a U-shaped relationship with risk of hip fracture, but a graded positive relationship with bone mineral density at the hip. SN - 0937-941X UR - https://www.unboundmedicine.com/medline/citation/17318666/Alcohol_consumption_bone_density_and_hip_fracture_among_older_adults:_the_cardiovascular_health_study_ L2 - https://doi.org/10.1007/s00198-006-0287-7 DB - PRIME DP - Unbound Medicine ER -