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Prevalence of the metabolic syndrome in German women with polycystic ovary syndrome.
Exp Clin Endocrinol Diabetes. 2007 Feb; 115(2):130-5.EC

Abstract

The aim of our study was to evaluate the prevalence of the metabolic syndrome (MBS) according to the current International Diabetes Federation definition in German PCOS women. Four hundred and eleven PCOS patients (age 28+/-6.3 years) and 82 controls (age 28+/-7.5 years) were evaluated for anthropometric and metabolic parameters by physical examination, blood testing and a personal interview including family history. A subgroup analysis of controls with BMI-matched PCOS women (BMI 22.9+/-2.8 kg/m (2)) was performed to detect PCOS specific differences in metabolic variables between the groups. The MBS was found in 33.8% of PCOS women compared to 7.3% in the control group. Parameters of insulin resistance, lipid-and glucose metabolism, mean values of all criteria of the MBS as well as the prevalence of the MBS were significantly different between the entire PCOS cohort and controls, but did not differ between BMI-matched PCOS women and controls. In addition, the prevalence of the MBS increased with age. Moreover, in PCOS women an increase in BMI and insulin resistance was accompanied by a further significant increase in the severity of clinical and biochemical hyperandrogenism. In PCOS women, while one out of three PCOS women had the MBS, the presence of metabolic abnormalities did not appear to be associated with PCOS per se, but rather correlated with age and the degree of obesity.

Authors+Show Affiliations

Division of Endocrinology, Department of Medicine, University Hospital of Essen Medical School, Essen, Germany. usanne.hahn@uni-essen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17318774

Citation

Hahn, S, et al. "Prevalence of the Metabolic Syndrome in German Women With Polycystic Ovary Syndrome." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 115, no. 2, 2007, pp. 130-5.
Hahn S, Tan S, Sack S, et al. Prevalence of the metabolic syndrome in German women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes. 2007;115(2):130-5.
Hahn, S., Tan, S., Sack, S., Kimmig, R., Quadbeck, B., Mann, K., & Janssen, O. E. (2007). Prevalence of the metabolic syndrome in German women with polycystic ovary syndrome. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 115(2), 130-5.
Hahn S, et al. Prevalence of the Metabolic Syndrome in German Women With Polycystic Ovary Syndrome. Exp Clin Endocrinol Diabetes. 2007;115(2):130-5. PubMed PMID: 17318774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of the metabolic syndrome in German women with polycystic ovary syndrome. AU - Hahn,S, AU - Tan,S, AU - Sack,S, AU - Kimmig,R, AU - Quadbeck,B, AU - Mann,K, AU - Janssen,O E, PY - 2007/2/24/pubmed PY - 2007/4/27/medline PY - 2007/2/24/entrez SP - 130 EP - 5 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 115 IS - 2 N2 - The aim of our study was to evaluate the prevalence of the metabolic syndrome (MBS) according to the current International Diabetes Federation definition in German PCOS women. Four hundred and eleven PCOS patients (age 28+/-6.3 years) and 82 controls (age 28+/-7.5 years) were evaluated for anthropometric and metabolic parameters by physical examination, blood testing and a personal interview including family history. A subgroup analysis of controls with BMI-matched PCOS women (BMI 22.9+/-2.8 kg/m (2)) was performed to detect PCOS specific differences in metabolic variables between the groups. The MBS was found in 33.8% of PCOS women compared to 7.3% in the control group. Parameters of insulin resistance, lipid-and glucose metabolism, mean values of all criteria of the MBS as well as the prevalence of the MBS were significantly different between the entire PCOS cohort and controls, but did not differ between BMI-matched PCOS women and controls. In addition, the prevalence of the MBS increased with age. Moreover, in PCOS women an increase in BMI and insulin resistance was accompanied by a further significant increase in the severity of clinical and biochemical hyperandrogenism. In PCOS women, while one out of three PCOS women had the MBS, the presence of metabolic abnormalities did not appear to be associated with PCOS per se, but rather correlated with age and the degree of obesity. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/17318774/Prevalence_of_the_metabolic_syndrome_in_German_women_with_polycystic_ovary_syndrome_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-967093 DB - PRIME DP - Unbound Medicine ER -