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Craniofacial variability index determined by three-dimensional ultrasound in isolated vs. syndromal fetal cleft lip/palate.
Ultrasound Obstet Gynecol. 2007 Mar; 29(3):265-70.UO

Abstract

OBJECTIVE

This study was undertaken to employ craniofacial pattern profile analysis in fetal facial clefts and to evaluate the craniofacial variability index (CVI) in distinguishing between isolated and syndromal clefts.

METHODS

Three-dimensional (3D) sonographic assessment of 16 different fetal craniofacial measurements was performed in each of eight pregnancies complicated by an isolated facial cleft and seven pregnancies with a syndromal cleft. The measurements covered various aspects of facial width, depth and height. Measured values were compared to gestational age-specific normal values for calculation of Z-scores and the CVI. The number of abnormal Z-scores, i.e. < - 2 or > + 2, found among the measured values and the CVI in the group of isolated facial clefts were compared to those in the group with syndromal clefts.

RESULTS

The CVI could be calculated in 14 of 15 fetuses (93%). More abnormal Z-scores and a higher mean CVI were found in the group with more severe (bilateral) facial clefts. Most abnormal values were found in the facial width measurements. Syndromal cleft lip/palate was associated with significantly more abnormal Z-scores and a higher mean CVI than isolated cleft lip/palate (P < 0.05).

CONCLUSION

Craniofacial variability index may be a valuable tool for distinguishing between isolated and syndromal fetal cleft lip/palate.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Erasmus MC, University Medical Centre Rotterdam, The Netherlands. NMRoelfsema@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17318943

Citation

Roelfsema, N M., et al. "Craniofacial Variability Index Determined By Three-dimensional Ultrasound in Isolated Vs. Syndromal Fetal Cleft Lip/palate." Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, vol. 29, no. 3, 2007, pp. 265-70.
Roelfsema NM, Hop WC, van Adrichem LN, et al. Craniofacial variability index determined by three-dimensional ultrasound in isolated vs. syndromal fetal cleft lip/palate. Ultrasound Obstet Gynecol. 2007;29(3):265-70.
Roelfsema, N. M., Hop, W. C., van Adrichem, L. N., & Wladimiroff, J. W. (2007). Craniofacial variability index determined by three-dimensional ultrasound in isolated vs. syndromal fetal cleft lip/palate. Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology, 29(3), 265-70.
Roelfsema NM, et al. Craniofacial Variability Index Determined By Three-dimensional Ultrasound in Isolated Vs. Syndromal Fetal Cleft Lip/palate. Ultrasound Obstet Gynecol. 2007;29(3):265-70. PubMed PMID: 17318943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Craniofacial variability index determined by three-dimensional ultrasound in isolated vs. syndromal fetal cleft lip/palate. AU - Roelfsema,N M, AU - Hop,W C J, AU - van Adrichem,L N A, AU - Wladimiroff,J W, PY - 2007/2/24/pubmed PY - 2008/2/20/medline PY - 2007/2/24/entrez SP - 265 EP - 70 JF - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JO - Ultrasound Obstet Gynecol VL - 29 IS - 3 N2 - OBJECTIVE: This study was undertaken to employ craniofacial pattern profile analysis in fetal facial clefts and to evaluate the craniofacial variability index (CVI) in distinguishing between isolated and syndromal clefts. METHODS: Three-dimensional (3D) sonographic assessment of 16 different fetal craniofacial measurements was performed in each of eight pregnancies complicated by an isolated facial cleft and seven pregnancies with a syndromal cleft. The measurements covered various aspects of facial width, depth and height. Measured values were compared to gestational age-specific normal values for calculation of Z-scores and the CVI. The number of abnormal Z-scores, i.e. < - 2 or > + 2, found among the measured values and the CVI in the group of isolated facial clefts were compared to those in the group with syndromal clefts. RESULTS: The CVI could be calculated in 14 of 15 fetuses (93%). More abnormal Z-scores and a higher mean CVI were found in the group with more severe (bilateral) facial clefts. Most abnormal values were found in the facial width measurements. Syndromal cleft lip/palate was associated with significantly more abnormal Z-scores and a higher mean CVI than isolated cleft lip/palate (P < 0.05). CONCLUSION: Craniofacial variability index may be a valuable tool for distinguishing between isolated and syndromal fetal cleft lip/palate. SN - 0960-7692 UR - https://www.unboundmedicine.com/medline/citation/17318943/Craniofacial_variability_index_determined_by_three_dimensional_ultrasound_in_isolated_vs__syndromal_fetal_cleft_lip/palate_ L2 - https://doi.org/10.1002/uog.3921 DB - PRIME DP - Unbound Medicine ER -