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The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy.
Patient Educ Couns 2007; 66(1):108-18PE

Abstract

OBJECTIVE

The possible association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life has been studied in high-risk breast cancer survivors 5 years following standard adjuvant (n=23) versus high-dose chemotherapy (n=24) and in early-stage breast cancer patients (n=29) (comparison group) following radiation therapy.

METHODS

A neuropsychological assessment covering attention, memory and executive functions was used together with the questionnaire for self-perceived deficits in attention (FEDA), the multidimensional fatigue inventory (MFI-20) and the EORTC-QLQ-C30.

RESULTS

Findings have shown that neuropsychological impairment is not directly associated with self-perceived cognitive deficits, fatigue and HRQOL. However, 46% of patients reported self-perceived cognitive deficits and 82% of the patients complained about cancer related fatigue. Except for reduced activity we did not find significant group differences, even though patients who received standard-dose chemotherapy had consistently higher levels of self-perceived cognitive deficits and fatigue, and the lowest HRQOL.

CONCLUSION

Results emphasize the need for psychosocial counseling and support during treatment phase and follow up care as well. Sensitive cancer-specific measures for the assessment of self-perceived cognitive deficits in different cognitive domains according to neuropsychological measurements are required.

PRACTICE IMPLICATIONS

The role of self-perceived cognitive deficits and fatigue should be considered in educational interventions and counseling. Specific rehabilitation measures should be developed, implemented and evaluated in order to meet the needs of these patients and to decrease the frequency of cognitive deficits following cancer treatment.

Authors+Show Affiliations

Institute of Medical Psychology, University Medical Center Hamburg-Eppendorf, Martinistr. 52-S35, 20246 Hamburg, Germany. mehnert@uke.uni-hanburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17320337

Citation

Mehnert, Anja, et al. "The Association Between Neuropsychological Impairment, Self-perceived Cognitive Deficits, Fatigue and Health Related Quality of Life in Breast Cancer Survivors Following Standard Adjuvant Versus High-dose Chemotherapy." Patient Education and Counseling, vol. 66, no. 1, 2007, pp. 108-18.
Mehnert A, Scherwath A, Schirmer L, et al. The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy. Patient Educ Couns. 2007;66(1):108-18.
Mehnert, A., Scherwath, A., Schirmer, L., Schleimer, B., Petersen, C., Schulz-Kindermann, F., ... Koch, U. (2007). The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy. Patient Education and Counseling, 66(1), pp. 108-18.
Mehnert A, et al. The Association Between Neuropsychological Impairment, Self-perceived Cognitive Deficits, Fatigue and Health Related Quality of Life in Breast Cancer Survivors Following Standard Adjuvant Versus High-dose Chemotherapy. Patient Educ Couns. 2007;66(1):108-18. PubMed PMID: 17320337.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life in breast cancer survivors following standard adjuvant versus high-dose chemotherapy. AU - Mehnert,Anja, AU - Scherwath,Angela, AU - Schirmer,Lena, AU - Schleimer,Barbara, AU - Petersen,Corinna, AU - Schulz-Kindermann,Frank, AU - Zander,Axel R, AU - Koch,Uwe, Y1 - 2007/02/21/ PY - 2006/08/08/received PY - 2006/11/16/revised PY - 2006/11/21/accepted PY - 2007/2/27/pubmed PY - 2007/6/1/medline PY - 2007/2/27/entrez SP - 108 EP - 18 JF - Patient education and counseling JO - Patient Educ Couns VL - 66 IS - 1 N2 - OBJECTIVE: The possible association between neuropsychological impairment, self-perceived cognitive deficits, fatigue and health related quality of life has been studied in high-risk breast cancer survivors 5 years following standard adjuvant (n=23) versus high-dose chemotherapy (n=24) and in early-stage breast cancer patients (n=29) (comparison group) following radiation therapy. METHODS: A neuropsychological assessment covering attention, memory and executive functions was used together with the questionnaire for self-perceived deficits in attention (FEDA), the multidimensional fatigue inventory (MFI-20) and the EORTC-QLQ-C30. RESULTS: Findings have shown that neuropsychological impairment is not directly associated with self-perceived cognitive deficits, fatigue and HRQOL. However, 46% of patients reported self-perceived cognitive deficits and 82% of the patients complained about cancer related fatigue. Except for reduced activity we did not find significant group differences, even though patients who received standard-dose chemotherapy had consistently higher levels of self-perceived cognitive deficits and fatigue, and the lowest HRQOL. CONCLUSION: Results emphasize the need for psychosocial counseling and support during treatment phase and follow up care as well. Sensitive cancer-specific measures for the assessment of self-perceived cognitive deficits in different cognitive domains according to neuropsychological measurements are required. PRACTICE IMPLICATIONS: The role of self-perceived cognitive deficits and fatigue should be considered in educational interventions and counseling. Specific rehabilitation measures should be developed, implemented and evaluated in order to meet the needs of these patients and to decrease the frequency of cognitive deficits following cancer treatment. SN - 0738-3991 UR - https://www.unboundmedicine.com/medline/citation/17320337/The_association_between_neuropsychological_impairment_self_perceived_cognitive_deficits_fatigue_and_health_related_quality_of_life_in_breast_cancer_survivors_following_standard_adjuvant_versus_high_dose_chemotherapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0738-3991(06)00405-8 DB - PRIME DP - Unbound Medicine ER -