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Five-year predictive factors of type 2 diabetes in men with impaired fasting glucose.
Diabetes Metab. 2007 Apr; 33(2):140-7.DM

Abstract

AIM

The outcome of 743 French men (age 20-60) with impaired fasting glucose (IFG) [blood glucose 6.1-6.9 mmol/l] at T1 was evaluated 5 years later, at T2.

METHODS

Personal and family medical history, smoking, nutritional habits, physical activity, blood pressure, body mass index (BMI) and waist girth, fasting biological data were collected at T1 and T2. Predictive factors for developing diabetes were compared between those who returned to normal fasting glucose and those who had diabetes, before and after adjustment for age, BMI, glucose and triglyceride (TG) levels.

RESULTS

At T2, 44%, 39%, 17% were classified as normal fasting plasma glucose (FPG), IFG or diabetic, respectively. Odd ratios for diabetes were 4.2 for men with a family history of diabetes (FHD), 3.4 if BMI > or = 25 kg/m(2), 2.9 if waist girth > or = 90 cm, 2.8 if TG > or = 2 mmol/l and 1.9 if no daily dairy products were eaten. Still significant after adjustment for age, BMI, glucose and TG levels were: FHD (P=0.001), no daily dairy products (P=0.001), high alcohol intake (P=0.02) and low physical activity (P = 0.02).

CONCLUSION

No daily dairy products, high alcohol intake and low physical activity were independent predictive factors of a 5-year onset of diabetes after adjusting for BMI, FHD, triglyceride and glucose levels at baseline. For a better prevention of diabetes, these findings give clues for behaviour modifications as soon as IFG is detected.

Authors+Show Affiliations

Unité d'endocrinologie et métabolisme, CHRU Bretonneau, 1 boulevard Tonnellé, 37044 Tours cedex 09, France. lecomte@med.univ-tours.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17320447

Citation

Lecomte, P, et al. "Five-year Predictive Factors of Type 2 Diabetes in Men With Impaired Fasting Glucose." Diabetes & Metabolism, vol. 33, no. 2, 2007, pp. 140-7.
Lecomte P, Vol S, Cacès E, et al. Five-year predictive factors of type 2 diabetes in men with impaired fasting glucose. Diabetes Metab. 2007;33(2):140-7.
Lecomte, P., Vol, S., Cacès, E., Born, C., Chabrolle, C., Lasfargues, G., Halimi, J. M., & Tichet, J. (2007). Five-year predictive factors of type 2 diabetes in men with impaired fasting glucose. Diabetes & Metabolism, 33(2), 140-7.
Lecomte P, et al. Five-year Predictive Factors of Type 2 Diabetes in Men With Impaired Fasting Glucose. Diabetes Metab. 2007;33(2):140-7. PubMed PMID: 17320447.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year predictive factors of type 2 diabetes in men with impaired fasting glucose. AU - Lecomte,P, AU - Vol,S, AU - Cacès,E, AU - Born,C, AU - Chabrolle,C, AU - Lasfargues,G, AU - Halimi,J-M, AU - Tichet,J, Y1 - 2007/02/22/ PY - 2006/05/30/received PY - 2006/11/06/accepted PY - 2007/2/27/pubmed PY - 2007/8/7/medline PY - 2007/2/27/entrez SP - 140 EP - 7 JF - Diabetes & metabolism JO - Diabetes Metab. VL - 33 IS - 2 N2 - AIM: The outcome of 743 French men (age 20-60) with impaired fasting glucose (IFG) [blood glucose 6.1-6.9 mmol/l] at T1 was evaluated 5 years later, at T2. METHODS: Personal and family medical history, smoking, nutritional habits, physical activity, blood pressure, body mass index (BMI) and waist girth, fasting biological data were collected at T1 and T2. Predictive factors for developing diabetes were compared between those who returned to normal fasting glucose and those who had diabetes, before and after adjustment for age, BMI, glucose and triglyceride (TG) levels. RESULTS: At T2, 44%, 39%, 17% were classified as normal fasting plasma glucose (FPG), IFG or diabetic, respectively. Odd ratios for diabetes were 4.2 for men with a family history of diabetes (FHD), 3.4 if BMI > or = 25 kg/m(2), 2.9 if waist girth > or = 90 cm, 2.8 if TG > or = 2 mmol/l and 1.9 if no daily dairy products were eaten. Still significant after adjustment for age, BMI, glucose and TG levels were: FHD (P=0.001), no daily dairy products (P=0.001), high alcohol intake (P=0.02) and low physical activity (P = 0.02). CONCLUSION: No daily dairy products, high alcohol intake and low physical activity were independent predictive factors of a 5-year onset of diabetes after adjusting for BMI, FHD, triglyceride and glucose levels at baseline. For a better prevention of diabetes, these findings give clues for behaviour modifications as soon as IFG is detected. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/17320447/Five_year_predictive_factors_of_type_2_diabetes_in_men_with_impaired_fasting_glucose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1262-3636(07)00020-1 DB - PRIME DP - Unbound Medicine ER -