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Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors.
Am J Med. 2007 Mar; 120(3 Suppl 1):S19-25.AJ

Abstract

Increased endocannabinoid (EC) system activity promotes excessive food intake and obesity in animals and humans. The EC system regulates food intake and hedonic reward through central mechanisms located within the hypothalamus and limbic forebrain. In rodent models, cannabinoid1 (CB1) receptor blockade reduces appetite and weight and prevents obesity and insulin resistance. The EC system also regulates food intake and metabolic factors through peripheral CB1 receptors located at multiple sites throughout the body, including adipose tissue, skeletal muscle, liver, and the gastrointestinal (GI) tract. In rodent models, CB1 receptor antagonists act in the liver to decrease lipogenesis, act in the GI tract to increase satiety, and function in adipose tissue to normalize adiponectin levels and reduce fat storage. The CB1 receptor antagonist rimonabant has been shown to reduce food intake and improve metabolic parameters, such as insulin resistance and fatty liver, in animal models of obesity. In preliminary human studies, upregulation of the EC system has been linked to obesity through mechanisms that include high-fat diet, insulin resistance, and genetic malfunction of an EC inactivation enzyme. Evidence suggests that CB1 receptor blockade is a novel therapeutic strategy that addresses the underlying mechanisms of both obesity and cardiometabolic risk.

Authors+Show Affiliations

Obesity Research Center at the University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. steve.woods@uc.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17320518

Citation

Woods, Stephen C.. "Role of the Endocannabinoid System in Regulating Cardiovascular and Metabolic Risk Factors." The American Journal of Medicine, vol. 120, no. 3 Suppl 1, 2007, pp. S19-25.
Woods SC. Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors. Am J Med. 2007;120(3 Suppl 1):S19-25.
Woods, S. C. (2007). Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors. The American Journal of Medicine, 120(3 Suppl 1), S19-25.
Woods SC. Role of the Endocannabinoid System in Regulating Cardiovascular and Metabolic Risk Factors. Am J Med. 2007;120(3 Suppl 1):S19-25. PubMed PMID: 17320518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors. A1 - Woods,Stephen C, PY - 2007/2/27/pubmed PY - 2007/4/10/medline PY - 2007/2/27/entrez SP - S19 EP - 25 JF - The American journal of medicine JO - Am J Med VL - 120 IS - 3 Suppl 1 N2 - Increased endocannabinoid (EC) system activity promotes excessive food intake and obesity in animals and humans. The EC system regulates food intake and hedonic reward through central mechanisms located within the hypothalamus and limbic forebrain. In rodent models, cannabinoid1 (CB1) receptor blockade reduces appetite and weight and prevents obesity and insulin resistance. The EC system also regulates food intake and metabolic factors through peripheral CB1 receptors located at multiple sites throughout the body, including adipose tissue, skeletal muscle, liver, and the gastrointestinal (GI) tract. In rodent models, CB1 receptor antagonists act in the liver to decrease lipogenesis, act in the GI tract to increase satiety, and function in adipose tissue to normalize adiponectin levels and reduce fat storage. The CB1 receptor antagonist rimonabant has been shown to reduce food intake and improve metabolic parameters, such as insulin resistance and fatty liver, in animal models of obesity. In preliminary human studies, upregulation of the EC system has been linked to obesity through mechanisms that include high-fat diet, insulin resistance, and genetic malfunction of an EC inactivation enzyme. Evidence suggests that CB1 receptor blockade is a novel therapeutic strategy that addresses the underlying mechanisms of both obesity and cardiometabolic risk. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/17320518/Role_of_the_endocannabinoid_system_in_regulating_cardiovascular_and_metabolic_risk_factors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(07)00034-4 DB - PRIME DP - Unbound Medicine ER -