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Male and female circumcision associated with prevalent HIV infection in virgins and adolescents in Kenya, Lesotho, and Tanzania.
Ann Epidemiol. 2007 Mar; 17(3):217-26.AE

Abstract

PURPOSE

Remarkable proportions of self-reported virgins and adolescents in eastern and southern Africa are infected with HIV, yet non-sexual routes of transmission have not been systematically investigated in such persons. Many observers in this region have recognized the potential for HIV transmission through unhygienic circumcision procedures. We assessed the relation between male and female circumcision (genital cutting) and prevalent HIV infection in Kenyan, Lesothoan, and Tanzanian virgins and adolescents.

METHODS

We analyzed data from recent cross-sectional national probability sample surveys of adolescents and adults in households, focusing on populations in which circumcision was common and usually occurred in puberty or later.

RESULTS

Circumcised male and female virgins were substantially more likely to be HIV infected than uncircumcised virgins (Kenyan females: 3.2% vs. 1.4%, odds ratio [OR] = 2.38; Kenyan males: 1.8% vs. 0%, OR undefined; Lesothoan males: 6.1% vs. 1.9%, OR 3.36; Tanzanian males: 2.9% vs. 1.0%, OR 2.99; weighted mean phi correlation = 0.07, 95% confidence interval, 0.03 to 0.11). Among adolescents, regardless of sexual experience, circumcision was just as strongly associated with prevalent HIV infection. However, uncircumcised adults were more likely to be HIV positive than circumcised adults. Self-reported sexual experience was independently related to HIV infection in adolescent Kenyan females, but was unrelated to HIV infection in adolescent Kenyan, Lesothoan, and Tanzanian males.

CONCLUSIONS

HIV transmission may occur through circumcision-related blood exposures in eastern and southern Africa.

Authors+Show Affiliations

Interdisciplinary Scientific Research, Seattle, WA 98115, USA. via www.interscientific.net/contact.htmlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17320788

Citation

Brewer, Devon D., et al. "Male and Female Circumcision Associated With Prevalent HIV Infection in Virgins and Adolescents in Kenya, Lesotho, and Tanzania." Annals of Epidemiology, vol. 17, no. 3, 2007, pp. 217-26.
Brewer DD, Potterat JJ, Roberts JM, et al. Male and female circumcision associated with prevalent HIV infection in virgins and adolescents in Kenya, Lesotho, and Tanzania. Ann Epidemiol. 2007;17(3):217-26.
Brewer, D. D., Potterat, J. J., Roberts, J. M., & Brody, S. (2007). Male and female circumcision associated with prevalent HIV infection in virgins and adolescents in Kenya, Lesotho, and Tanzania. Annals of Epidemiology, 17(3), 217-26.
Brewer DD, et al. Male and Female Circumcision Associated With Prevalent HIV Infection in Virgins and Adolescents in Kenya, Lesotho, and Tanzania. Ann Epidemiol. 2007;17(3):217-26. PubMed PMID: 17320788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Male and female circumcision associated with prevalent HIV infection in virgins and adolescents in Kenya, Lesotho, and Tanzania. AU - Brewer,Devon D, AU - Potterat,John J, AU - Roberts,John M,Jr AU - Brody,Stuart, PY - 2006/07/06/received PY - 2006/10/11/revised PY - 2006/10/17/accepted PY - 2007/2/27/pubmed PY - 2007/4/11/medline PY - 2007/2/27/entrez SP - 217 EP - 26 JF - Annals of epidemiology JO - Ann Epidemiol VL - 17 IS - 3 N2 - PURPOSE: Remarkable proportions of self-reported virgins and adolescents in eastern and southern Africa are infected with HIV, yet non-sexual routes of transmission have not been systematically investigated in such persons. Many observers in this region have recognized the potential for HIV transmission through unhygienic circumcision procedures. We assessed the relation between male and female circumcision (genital cutting) and prevalent HIV infection in Kenyan, Lesothoan, and Tanzanian virgins and adolescents. METHODS: We analyzed data from recent cross-sectional national probability sample surveys of adolescents and adults in households, focusing on populations in which circumcision was common and usually occurred in puberty or later. RESULTS: Circumcised male and female virgins were substantially more likely to be HIV infected than uncircumcised virgins (Kenyan females: 3.2% vs. 1.4%, odds ratio [OR] = 2.38; Kenyan males: 1.8% vs. 0%, OR undefined; Lesothoan males: 6.1% vs. 1.9%, OR 3.36; Tanzanian males: 2.9% vs. 1.0%, OR 2.99; weighted mean phi correlation = 0.07, 95% confidence interval, 0.03 to 0.11). Among adolescents, regardless of sexual experience, circumcision was just as strongly associated with prevalent HIV infection. However, uncircumcised adults were more likely to be HIV positive than circumcised adults. Self-reported sexual experience was independently related to HIV infection in adolescent Kenyan females, but was unrelated to HIV infection in adolescent Kenyan, Lesothoan, and Tanzanian males. CONCLUSIONS: HIV transmission may occur through circumcision-related blood exposures in eastern and southern Africa. SN - 1047-2797 UR - https://www.unboundmedicine.com/medline/citation/17320788/Male_and_female_circumcision_associated_with_prevalent_HIV_infection_in_virgins_and_adolescents_in_Kenya_Lesotho_and_Tanzania_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1047-2797(06)00265-1 DB - PRIME DP - Unbound Medicine ER -