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Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients.
Nutrition 2007; 23(3):242-7N

Abstract

OBJECTIVE

We evaluated the effects of folic acid on homocysteine levels and oxidative stress in 46 stable patients on hemodialysis.

METHODS

This double-blind, placebo-controlled, randomized trial assessed the effects of 6 mo of 10 mg of folic acid (26 patients) or placebo (20 patients) given three times weekly after each dialysis under nurse supervision on homocysteine levels, total plasma antioxidant capacity, and hydroperoxide plasma levels.

RESULTS

Folic acid treatment normalized plasma homocysteine levels in most patients, significantly increased total plasma antioxidant capacity levels, but had no significant effect on hydroperoxide levels. Placebo treatment had no statistically significant effect on the three parameters.

CONCLUSION

The folic acid therapy protocol effectively lowered plasma homocysteine levels and improved the total plasma antioxidant capacity in hemodialysis patients. Further studies are required to assess the usefulness of folic acid for decreasing cardiovascular mortality in patients with chronic kidney disease.

Authors+Show Affiliations

Nephrology Section, Department of Internal Medicine, State University of Londrina, Londrina, Brazil. vddelfino@sercomtel.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17321110

Citation

Alvares Delfino, Vinicius Daher, et al. "Folic Acid Therapy Reduces Plasma Homocysteine Levels and Improves Plasma Antioxidant Capacity in Hemodialysis Patients." Nutrition (Burbank, Los Angeles County, Calif.), vol. 23, no. 3, 2007, pp. 242-7.
Alvares Delfino VD, de Andrade Vianna AC, Mocelin AJ, et al. Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients. Nutrition. 2007;23(3):242-7.
Alvares Delfino, V. D., de Andrade Vianna, A. C., Mocelin, A. J., Barbosa, D. S., Mise, R. A., & Matsuo, T. (2007). Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients. Nutrition (Burbank, Los Angeles County, Calif.), 23(3), pp. 242-7.
Alvares Delfino VD, et al. Folic Acid Therapy Reduces Plasma Homocysteine Levels and Improves Plasma Antioxidant Capacity in Hemodialysis Patients. Nutrition. 2007;23(3):242-7. PubMed PMID: 17321110.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid therapy reduces plasma homocysteine levels and improves plasma antioxidant capacity in hemodialysis patients. AU - Alvares Delfino,Vinicius Daher, AU - de Andrade Vianna,Areuza Célia, AU - Mocelin,Altair Jacob, AU - Barbosa,Décio Sabbatini, AU - Mise,Rosana Aiko, AU - Matsuo,Tiemi, Y1 - 2007/02/22/ PY - 2006/05/24/received PY - 2007/01/04/revised PY - 2007/01/04/accepted PY - 2007/2/27/pubmed PY - 2007/5/30/medline PY - 2007/2/27/entrez SP - 242 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 23 IS - 3 N2 - OBJECTIVE: We evaluated the effects of folic acid on homocysteine levels and oxidative stress in 46 stable patients on hemodialysis. METHODS: This double-blind, placebo-controlled, randomized trial assessed the effects of 6 mo of 10 mg of folic acid (26 patients) or placebo (20 patients) given three times weekly after each dialysis under nurse supervision on homocysteine levels, total plasma antioxidant capacity, and hydroperoxide plasma levels. RESULTS: Folic acid treatment normalized plasma homocysteine levels in most patients, significantly increased total plasma antioxidant capacity levels, but had no significant effect on hydroperoxide levels. Placebo treatment had no statistically significant effect on the three parameters. CONCLUSION: The folic acid therapy protocol effectively lowered plasma homocysteine levels and improved the total plasma antioxidant capacity in hemodialysis patients. Further studies are required to assess the usefulness of folic acid for decreasing cardiovascular mortality in patients with chronic kidney disease. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/17321110/Folic_acid_therapy_reduces_plasma_homocysteine_levels_and_improves_plasma_antioxidant_capacity_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(07)00009-3 DB - PRIME DP - Unbound Medicine ER -