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TRP channels: targets for the relief of pain.
Biochim Biophys Acta. 2007 Aug; 1772(8):989-1003.BB

Abstract

Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical, thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of these pain syndromes, an approach to developing successful therapies may be to target ion channels that contribute to the detection of thermal, mechanical and chemical stimuli and promote the sensitization and activation of nociceptors. Transient Receptor Potential (TRP) channels have emerged as a family of evolutionarily conserved ligand-gated ion channels that contribute to the detection of physical stimuli. Six TRPs (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1) have been shown to be expressed in primary afferent nociceptors, pain sensing neurons, where they act as transducers for thermal, chemical and mechanical stimuli. This short review focuses on their contribution to pain hypersensitivity associated with peripheral inflammatory and neuropathic pain states.

Authors+Show Affiliations

Department of Oral and Maxillofacial Surgery, Box 0440, University of California, San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0440, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17321113

Citation

Levine, Jon D., and Nicole Alessandri-Haber. "TRP Channels: Targets for the Relief of Pain." Biochimica Et Biophysica Acta, vol. 1772, no. 8, 2007, pp. 989-1003.
Levine JD, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochim Biophys Acta. 2007;1772(8):989-1003.
Levine, J. D., & Alessandri-Haber, N. (2007). TRP channels: targets for the relief of pain. Biochimica Et Biophysica Acta, 1772(8), 989-1003.
Levine JD, Alessandri-Haber N. TRP Channels: Targets for the Relief of Pain. Biochim Biophys Acta. 2007;1772(8):989-1003. PubMed PMID: 17321113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TRP channels: targets for the relief of pain. AU - Levine,Jon D, AU - Alessandri-Haber,Nicole, Y1 - 2007/01/23/ PY - 2006/12/01/received PY - 2007/01/12/revised PY - 2007/01/16/accepted PY - 2007/2/27/pubmed PY - 2007/9/29/medline PY - 2007/2/27/entrez SP - 989 EP - 1003 JF - Biochimica et biophysica acta JO - Biochim Biophys Acta VL - 1772 IS - 8 N2 - Patients with inflammatory or neuropathic pain experience hypersensitivity to mechanical, thermal and/or chemical stimuli. Given the diverse etiologies and molecular mechanisms of these pain syndromes, an approach to developing successful therapies may be to target ion channels that contribute to the detection of thermal, mechanical and chemical stimuli and promote the sensitization and activation of nociceptors. Transient Receptor Potential (TRP) channels have emerged as a family of evolutionarily conserved ligand-gated ion channels that contribute to the detection of physical stimuli. Six TRPs (TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1) have been shown to be expressed in primary afferent nociceptors, pain sensing neurons, where they act as transducers for thermal, chemical and mechanical stimuli. This short review focuses on their contribution to pain hypersensitivity associated with peripheral inflammatory and neuropathic pain states. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/17321113/TRP_channels:_targets_for_the_relief_of_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(07)00032-4 DB - PRIME DP - Unbound Medicine ER -