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Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly.
Hum Immunol. 2007 Feb; 68(2):86-90.HI

Abstract

Despite general acceptance that immunologic changes are associated with aging and latent infection with Cytomegalovirus (CMV), no clear-cut distinction has so far been made between strictly age-related and CMV-induced changes. We therefore compared CD4+ and CD8+ naïve (CD45RA+CD28+), memory (CD45RA-CD28+), and effector (CD28-) T cells in CMV-positive (n = 164) and CMV-negative (n = 87) elderly persons and correlated CD8+ and CD4+ effector T cells with other T-cell subpopulations. Percentages of CD8+ as well as CD4+ effector T cells were higher, but percentages of naïve and memory cells were lower in CMV-positive compared to CMV-negative elderly persons. Negative correlations within CD8+ T-cell subsets were found to be present in both CMV-positive and CMV-negative elderly individuals. In contrast, correlations within CD4+ T-cell subpopulations and a positive correlation between CD8+ and CD4+ effector T cells were found in CMV-positive individuals only. Our results demonstrate that (a) in the elderly different T-cell subsets compete for space within the CD8+, but not the CD4+ T-cell population; (b) CMV induces changes in the CD4+ compartment that differ from the solely age-related changes seen in CMV-negative elderly population; and (c) the CMV-status of a population has to be taken into account before a conclusion on the effect of aging on the composition of the T-cell pool can be reached.

Authors+Show Affiliations

Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17321897

Citation

Weinberger, Birgit, et al. "Healthy Aging and Latent Infection With CMV Lead to Distinct Changes in CD8+ and CD4+ T-cell Subsets in the Elderly." Human Immunology, vol. 68, no. 2, 2007, pp. 86-90.
Weinberger B, Lazuardi L, Weiskirchner I, et al. Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Hum Immunol. 2007;68(2):86-90.
Weinberger, B., Lazuardi, L., Weiskirchner, I., Keller, M., Neuner, C., Fischer, K. H., Neuman, B., Würzner, R., & Grubeck-Loebenstein, B. (2007). Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Human Immunology, 68(2), 86-90.
Weinberger B, et al. Healthy Aging and Latent Infection With CMV Lead to Distinct Changes in CD8+ and CD4+ T-cell Subsets in the Elderly. Hum Immunol. 2007;68(2):86-90. PubMed PMID: 17321897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. AU - Weinberger,Birgit, AU - Lazuardi,Lutfan, AU - Weiskirchner,Ilka, AU - Keller,Michael, AU - Neuner,Christoph, AU - Fischer,Karl-Heinz, AU - Neuman,Ber, AU - Würzner,Reinhard, AU - Grubeck-Loebenstein,Beatrix, Y1 - 2006/12/05/ PY - 2006/08/18/received PY - 2006/10/16/revised PY - 2006/10/31/accepted PY - 2007/2/27/pubmed PY - 2007/6/9/medline PY - 2007/2/27/entrez SP - 86 EP - 90 JF - Human immunology JO - Hum Immunol VL - 68 IS - 2 N2 - Despite general acceptance that immunologic changes are associated with aging and latent infection with Cytomegalovirus (CMV), no clear-cut distinction has so far been made between strictly age-related and CMV-induced changes. We therefore compared CD4+ and CD8+ naïve (CD45RA+CD28+), memory (CD45RA-CD28+), and effector (CD28-) T cells in CMV-positive (n = 164) and CMV-negative (n = 87) elderly persons and correlated CD8+ and CD4+ effector T cells with other T-cell subpopulations. Percentages of CD8+ as well as CD4+ effector T cells were higher, but percentages of naïve and memory cells were lower in CMV-positive compared to CMV-negative elderly persons. Negative correlations within CD8+ T-cell subsets were found to be present in both CMV-positive and CMV-negative elderly individuals. In contrast, correlations within CD4+ T-cell subpopulations and a positive correlation between CD8+ and CD4+ effector T cells were found in CMV-positive individuals only. Our results demonstrate that (a) in the elderly different T-cell subsets compete for space within the CD8+, but not the CD4+ T-cell population; (b) CMV induces changes in the CD4+ compartment that differ from the solely age-related changes seen in CMV-negative elderly population; and (c) the CMV-status of a population has to be taken into account before a conclusion on the effect of aging on the composition of the T-cell pool can be reached. SN - 0198-8859 UR - https://www.unboundmedicine.com/medline/citation/17321897/Healthy_aging_and_latent_infection_with_CMV_lead_to_distinct_changes_in_CD8+_and_CD4+_T_cell_subsets_in_the_elderly_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0198-8859(06)00577-5 DB - PRIME DP - Unbound Medicine ER -