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Rimonabant: a novel selective cannabinoid-1 receptor antagonist for treatment of obesity.
Am J Health Syst Pharm. 2007 Mar 01; 64(5):481-9.AJ

Abstract

PURPOSE

The pharmacology, pharmacokinetics, clinical efficacy, safety, drug interactions, and dosage and administration of rimonabant in the treatment of obesity and related metabolic factors are reviewed.

SUMMARY

Discovery of the cannabinoid receptors has led to the development of rimonabant, a cannabinoid-1 (CB(1)) antagonist. Selective blockade of this receptor has been shown to lead to decreased appetite and food intake in animal models. Clinical studies have shown that rimonabant 20 mg once daily produces significant decreases in weight and waist circumference in obese human subjects and improves the lipid profile and glucose control. The frequency of metabolic syndrome also decreased significantly with rimonabant 20 mg daily. Limited data are available regarding the pharmacokinetics and pharmacodynamics of rimonabant. Preclinical data have demonstrated a long duration of action. As of yet, no drug-drug, drug-food, or drug-disease interactions have been identified with rimonabant. Adverse reactions occurred rarely, with nausea, dizziness, diarrhea, arthralgia, and back pain being the most common. Psychiatric disorders, including depression and anxiety, were the most common reasons for subjects to withdraw from rimonabant studies. Rimonabant has been shown to be safe for up to two years of treatment. Further research will clarify currently unknown areas, including pharmacokinetics, drug interactions, and the drug's role in standard therapy.

CONCLUSION

Rimonabant, a selective CB(1) antagonist, is a novel treatment option for obese and overweight individuals. Significant weight loss, decrease in waist circumference, and improvements in lipid profile and glucose control have been shown in clinical trials of rimonabant.

Authors+Show Affiliations

College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Queens, NY 11439, USA. patelp2@stjohns.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17322160

Citation

Patel, Priti N., and Rolee Pathak. "Rimonabant: a Novel Selective Cannabinoid-1 Receptor Antagonist for Treatment of Obesity." American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, vol. 64, no. 5, 2007, pp. 481-9.
Patel PN, Pathak R. Rimonabant: a novel selective cannabinoid-1 receptor antagonist for treatment of obesity. Am J Health Syst Pharm. 2007;64(5):481-9.
Patel, P. N., & Pathak, R. (2007). Rimonabant: a novel selective cannabinoid-1 receptor antagonist for treatment of obesity. American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, 64(5), 481-9.
Patel PN, Pathak R. Rimonabant: a Novel Selective Cannabinoid-1 Receptor Antagonist for Treatment of Obesity. Am J Health Syst Pharm. 2007 Mar 1;64(5):481-9. PubMed PMID: 17322160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rimonabant: a novel selective cannabinoid-1 receptor antagonist for treatment of obesity. AU - Patel,Priti N, AU - Pathak,Rolee, PY - 2007/2/27/pubmed PY - 2007/4/4/medline PY - 2007/2/27/entrez SP - 481 EP - 9 JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists JO - Am J Health Syst Pharm VL - 64 IS - 5 N2 - PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, safety, drug interactions, and dosage and administration of rimonabant in the treatment of obesity and related metabolic factors are reviewed. SUMMARY: Discovery of the cannabinoid receptors has led to the development of rimonabant, a cannabinoid-1 (CB(1)) antagonist. Selective blockade of this receptor has been shown to lead to decreased appetite and food intake in animal models. Clinical studies have shown that rimonabant 20 mg once daily produces significant decreases in weight and waist circumference in obese human subjects and improves the lipid profile and glucose control. The frequency of metabolic syndrome also decreased significantly with rimonabant 20 mg daily. Limited data are available regarding the pharmacokinetics and pharmacodynamics of rimonabant. Preclinical data have demonstrated a long duration of action. As of yet, no drug-drug, drug-food, or drug-disease interactions have been identified with rimonabant. Adverse reactions occurred rarely, with nausea, dizziness, diarrhea, arthralgia, and back pain being the most common. Psychiatric disorders, including depression and anxiety, were the most common reasons for subjects to withdraw from rimonabant studies. Rimonabant has been shown to be safe for up to two years of treatment. Further research will clarify currently unknown areas, including pharmacokinetics, drug interactions, and the drug's role in standard therapy. CONCLUSION: Rimonabant, a selective CB(1) antagonist, is a novel treatment option for obese and overweight individuals. Significant weight loss, decrease in waist circumference, and improvements in lipid profile and glucose control have been shown in clinical trials of rimonabant. SN - 1079-2082 UR - https://www.unboundmedicine.com/medline/citation/17322160/Rimonabant:_a_novel_selective_cannabinoid_1_receptor_antagonist_for_treatment_of_obesity_ L2 - https://academic.oup.com/ajhp/article-lookup/doi/10.2146/060258 DB - PRIME DP - Unbound Medicine ER -