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The relationship between flow-mediated dilatation and left ventricular function in type 2 diabetic patients with microalbuminuria.
Endocrine. 2006 Oct; 30(2):197-202.E

Abstract

OBJECTIVE

The aim of this study was to assess the relationship between flow-mediated dilatation (FMD) and left ventricular (LV) systolic and diastolic function in type 2 diabetic patients with or without microalbuminuria.

RESEARCH DESIGN AND METHODS

We prospectively evaluated 68 consecutive patients (36 women, 32 men; mean age 57 +/- 11 yr) with type 2 diabetes mellitus (DM). Patients were divided into two groups according to whether or not they had microalbuminuria: group 1 (n = 29, mean age 58 +/- 10 yr) with microalbuminuria and group 2 (n = 39, mean age 56 +/- 10 yr) without microalbuminuria. LV function was assessed by classical methods and Doppler tissue imaging (DTI). Left ventricular ejection fraction (EF), interventricular (IVS) and posterior wall (PW) thickness, peak early (E) and late (A) transmitral filling velocities, their ratio (E/A) and deceleration time of the mitral E wave (DT), LV isovolumetric relaxation time (IVRT), flow propagation of velocity (Vp), and E/Vp were evaluated by conventional echocardiography. Early diastolic (Em), late diastolic (Am), and peak systolic (Sm) mitral annular velocities were measured. Em/Am and the ratio of early diastolic mitral inflow velocity to Em (E/Em), which is a reasonably good index for predicting elevated LV filling pressure, were calculated by DTI. Endothelial function, measured as flow-mediated dilatation of the brachial artery using ultrasound, was calculated in two groups.

RESULTS

FMD was lower in those with microalbuminuria than those without (8.8 +/- 6.44% vs 12.6 +/- 7.24%, p = 0.03). Group 1 had longer DT (223 +/- 39 ms vs 199 +/- 37 ms, p = 0.01) and longer IVRT (109 +/- 13 ms vs 100 +/- 13 ms, p = 0.03) than that of group 2 with conventional echocardiography. Group 1 had significantly lower Em/ Am (0.79 +/- 0.27 cm/s vs 1.02 +/- 0.44 cm/s, p = 0.01), lower Vp (40.4 +/- 9.98 vs 50.4 +/- 19.01 cm/s, p = 0.01) than that of group 2. Group 1 had significantly higher serum creatinine (1 +/- 0.33 mg/dL vs 0.7 +/- 0.19, p = 0.001). In logistic regression analysis, FMD was the only variable independently related to microalbuminuria. FMD was positively correlated with EF (r = 0.43, p = 0.02) and E/A (r = 0.40, p = 0.03), and negatively correlated with E/Em (r = 0.41, p = 0.04) and E/Vp (r = 0.41, p = 0.04) only in patients with microalbuminuria.

CONCLUSION

It was found that left ventricular diastolic function and FMD are impaired in type 2 diabetic patients with microalbuminuria. FMD may be related to LV diastolic dysfunction only in patients with microalbuminuria.

Authors+Show Affiliations

KTU Faculty of Medicine, Department of Cardiology, Trabzon-Turkey. mbaykan@meds.ktu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17322579

Citation

Baykan, Merih, et al. "The Relationship Between Flow-mediated Dilatation and Left Ventricular Function in Type 2 Diabetic Patients With Microalbuminuria." Endocrine, vol. 30, no. 2, 2006, pp. 197-202.
Baykan M, Erdogan T, Erem C, et al. The relationship between flow-mediated dilatation and left ventricular function in type 2 diabetic patients with microalbuminuria. Endocrine. 2006;30(2):197-202.
Baykan, M., Erdogan, T., Erem, C., Hacihasanoglu, A., Gedikli, O., Küçükosmanoglu, M., Celik, S., & Orem, C. (2006). The relationship between flow-mediated dilatation and left ventricular function in type 2 diabetic patients with microalbuminuria. Endocrine, 30(2), 197-202.
Baykan M, et al. The Relationship Between Flow-mediated Dilatation and Left Ventricular Function in Type 2 Diabetic Patients With Microalbuminuria. Endocrine. 2006;30(2):197-202. PubMed PMID: 17322579.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between flow-mediated dilatation and left ventricular function in type 2 diabetic patients with microalbuminuria. AU - Baykan,Merih, AU - Erdogan,Turan, AU - Erem,Cihangir, AU - Hacihasanoglu,Arif, AU - Gedikli,Omer, AU - Küçükosmanoglu,Mehmet, AU - Celik,Sukru, AU - Orem,Cihan, PY - 2006/07/18/received PY - 2006/09/04/revised PY - 2006/10/02/accepted PY - 2007/2/27/pubmed PY - 2007/4/24/medline PY - 2007/2/27/entrez SP - 197 EP - 202 JF - Endocrine JO - Endocrine VL - 30 IS - 2 N2 - OBJECTIVE: The aim of this study was to assess the relationship between flow-mediated dilatation (FMD) and left ventricular (LV) systolic and diastolic function in type 2 diabetic patients with or without microalbuminuria. RESEARCH DESIGN AND METHODS: We prospectively evaluated 68 consecutive patients (36 women, 32 men; mean age 57 +/- 11 yr) with type 2 diabetes mellitus (DM). Patients were divided into two groups according to whether or not they had microalbuminuria: group 1 (n = 29, mean age 58 +/- 10 yr) with microalbuminuria and group 2 (n = 39, mean age 56 +/- 10 yr) without microalbuminuria. LV function was assessed by classical methods and Doppler tissue imaging (DTI). Left ventricular ejection fraction (EF), interventricular (IVS) and posterior wall (PW) thickness, peak early (E) and late (A) transmitral filling velocities, their ratio (E/A) and deceleration time of the mitral E wave (DT), LV isovolumetric relaxation time (IVRT), flow propagation of velocity (Vp), and E/Vp were evaluated by conventional echocardiography. Early diastolic (Em), late diastolic (Am), and peak systolic (Sm) mitral annular velocities were measured. Em/Am and the ratio of early diastolic mitral inflow velocity to Em (E/Em), which is a reasonably good index for predicting elevated LV filling pressure, were calculated by DTI. Endothelial function, measured as flow-mediated dilatation of the brachial artery using ultrasound, was calculated in two groups. RESULTS: FMD was lower in those with microalbuminuria than those without (8.8 +/- 6.44% vs 12.6 +/- 7.24%, p = 0.03). Group 1 had longer DT (223 +/- 39 ms vs 199 +/- 37 ms, p = 0.01) and longer IVRT (109 +/- 13 ms vs 100 +/- 13 ms, p = 0.03) than that of group 2 with conventional echocardiography. Group 1 had significantly lower Em/ Am (0.79 +/- 0.27 cm/s vs 1.02 +/- 0.44 cm/s, p = 0.01), lower Vp (40.4 +/- 9.98 vs 50.4 +/- 19.01 cm/s, p = 0.01) than that of group 2. Group 1 had significantly higher serum creatinine (1 +/- 0.33 mg/dL vs 0.7 +/- 0.19, p = 0.001). In logistic regression analysis, FMD was the only variable independently related to microalbuminuria. FMD was positively correlated with EF (r = 0.43, p = 0.02) and E/A (r = 0.40, p = 0.03), and negatively correlated with E/Em (r = 0.41, p = 0.04) and E/Vp (r = 0.41, p = 0.04) only in patients with microalbuminuria. CONCLUSION: It was found that left ventricular diastolic function and FMD are impaired in type 2 diabetic patients with microalbuminuria. FMD may be related to LV diastolic dysfunction only in patients with microalbuminuria. SN - 1355-008X UR - https://www.unboundmedicine.com/medline/citation/17322579/The_relationship_between_flow_mediated_dilatation_and_left_ventricular_function_in_type_2_diabetic_patients_with_microalbuminuria_ L2 - https://dx.doi.org/10.1385/ENDO:30:2:197 DB - PRIME DP - Unbound Medicine ER -