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Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol.
Behav Neurosci. 2007 Feb; 121(1):11-20.BN

Abstract

Effects of cortisol on human mood during stress situations are still incompletely understood, although this topic has important clinical implications. In this experiment, the mood of 44 healthy young women (all oral contraceptive users) was examined. A double-blind, randomized, placebo-controlled time series paradigm was used. Subjects were treated with either 30-mg cortisol or placebo orally. Forty-five minutes later, subjects attended a psychosocial stress procedure (Trier Social Stress Test; TSST; C. Kirschbaum, K. M. Pirke, & D. H. Hellhammer, 1993). The course of the subjects' mood as well as salivary cortisol and alpha-amylase levels were measured before and after the TSST. With regard to mood, it was found that the groups did not differ in mood before the TSST. After stress exposure, the subjective ratings of current mood state of cortisol-treated women were significantly less negative than that of placebo-treated subjects. These findings show that raising cortisol levels prior to acute stress has a protective effect on mood during stress situations. Results are discussed with regard to the context of specific adaptive effects of cortisol and the role of cortisol in posttraumatic stress disorder.

Authors+Show Affiliations

Department of Psychology, University of Bielefeld, Bielefeld, Germany.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17324047

Citation

Het, Serkan, and Oliver T. Wolf. "Mood Changes in Response to Psychosocial Stress in Healthy Young Women: Effects of Pretreatment With Cortisol." Behavioral Neuroscience, vol. 121, no. 1, 2007, pp. 11-20.
Het S, Wolf OT. Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol. Behav Neurosci. 2007;121(1):11-20.
Het, S., & Wolf, O. T. (2007). Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol. Behavioral Neuroscience, 121(1), 11-20.
Het S, Wolf OT. Mood Changes in Response to Psychosocial Stress in Healthy Young Women: Effects of Pretreatment With Cortisol. Behav Neurosci. 2007;121(1):11-20. PubMed PMID: 17324047.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mood changes in response to psychosocial stress in healthy young women: effects of pretreatment with cortisol. AU - Het,Serkan, AU - Wolf,Oliver T, PY - 2007/2/28/pubmed PY - 2007/4/6/medline PY - 2007/2/28/entrez SP - 11 EP - 20 JF - Behavioral neuroscience JO - Behav Neurosci VL - 121 IS - 1 N2 - Effects of cortisol on human mood during stress situations are still incompletely understood, although this topic has important clinical implications. In this experiment, the mood of 44 healthy young women (all oral contraceptive users) was examined. A double-blind, randomized, placebo-controlled time series paradigm was used. Subjects were treated with either 30-mg cortisol or placebo orally. Forty-five minutes later, subjects attended a psychosocial stress procedure (Trier Social Stress Test; TSST; C. Kirschbaum, K. M. Pirke, & D. H. Hellhammer, 1993). The course of the subjects' mood as well as salivary cortisol and alpha-amylase levels were measured before and after the TSST. With regard to mood, it was found that the groups did not differ in mood before the TSST. After stress exposure, the subjective ratings of current mood state of cortisol-treated women were significantly less negative than that of placebo-treated subjects. These findings show that raising cortisol levels prior to acute stress has a protective effect on mood during stress situations. Results are discussed with regard to the context of specific adaptive effects of cortisol and the role of cortisol in posttraumatic stress disorder. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/17324047/Mood_changes_in_response_to_psychosocial_stress_in_healthy_young_women:_effects_of_pretreatment_with_cortisol_ L2 - http://content.apa.org/journals/bne/121/1/11 DB - PRIME DP - Unbound Medicine ER -