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Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties.
Int J Pharm. 2007 Jun 29; 338(1-2):110-8.IJ

Abstract

The influence of particle size of MCC, as a binder, and theophylline, as an active pharmaceutical ingredient on the process of roll compaction/dry granulation was investigated using a D-optimal design of experiments. Examined parameters were particle size of both starting materials, fraction of theophylline and ribbon porosity. Therefore, different binary mixtures were roll compacted, dry granulated and compressed into tablets. Flowability of powders and granules and tensile strength of tablets made from powders or granules were the focus of this study. This study showed that a decrease in particle size of MCC or theophylline resulted in an increase of tensile strength even after roll compaction/dry granulation. Comparing tensile strength of tablets made from powder using large size MCC with ones made from granules with small sized MCC revealed that the tensile strength of tablets produced from granules was equal or even higher than tensile strength from direct compressed tablets. Furthermore, using small sized MCC instead of large sized MCC led to larger granules with better flowability. It is shown that the fraction of binder can be reduced without a loss of tensile strength of the final tablets by size reduction of MCC.

Authors+Show Affiliations

Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine-University, Universitaetsstr. 1, 40225 Duesseldorf, Germany.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17324537

Citation

Herting, Michael G., and Peter Kleinebudde. "Roll Compaction/dry Granulation: Effect of Raw Material Particle Size On Granule and Tablet Properties." International Journal of Pharmaceutics, vol. 338, no. 1-2, 2007, pp. 110-8.
Herting MG, Kleinebudde P. Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties. Int J Pharm. 2007;338(1-2):110-8.
Herting, M. G., & Kleinebudde, P. (2007). Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties. International Journal of Pharmaceutics, 338(1-2), 110-8.
Herting MG, Kleinebudde P. Roll Compaction/dry Granulation: Effect of Raw Material Particle Size On Granule and Tablet Properties. Int J Pharm. 2007 Jun 29;338(1-2):110-8. PubMed PMID: 17324537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Roll compaction/dry granulation: effect of raw material particle size on granule and tablet properties. AU - Herting,Michael G, AU - Kleinebudde,Peter, Y1 - 2007/01/28/ PY - 2006/11/06/received PY - 2007/01/10/revised PY - 2007/01/23/accepted PY - 2007/2/28/pubmed PY - 2007/7/20/medline PY - 2007/2/28/entrez SP - 110 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 338 IS - 1-2 N2 - The influence of particle size of MCC, as a binder, and theophylline, as an active pharmaceutical ingredient on the process of roll compaction/dry granulation was investigated using a D-optimal design of experiments. Examined parameters were particle size of both starting materials, fraction of theophylline and ribbon porosity. Therefore, different binary mixtures were roll compacted, dry granulated and compressed into tablets. Flowability of powders and granules and tensile strength of tablets made from powders or granules were the focus of this study. This study showed that a decrease in particle size of MCC or theophylline resulted in an increase of tensile strength even after roll compaction/dry granulation. Comparing tensile strength of tablets made from powder using large size MCC with ones made from granules with small sized MCC revealed that the tensile strength of tablets produced from granules was equal or even higher than tensile strength from direct compressed tablets. Furthermore, using small sized MCC instead of large sized MCC led to larger granules with better flowability. It is shown that the fraction of binder can be reduced without a loss of tensile strength of the final tablets by size reduction of MCC. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17324537/Roll_compaction/dry_granulation:_effect_of_raw_material_particle_size_on_granule_and_tablet_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(07)00087-7 DB - PRIME DP - Unbound Medicine ER -