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Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults.
J Am Diet Assoc 2007; 107(3):422-32JA

Abstract

OBJECTIVE

To determine if a ginkgo biloba-containing supplement improves cognitive function and quality of life, alters primary hemostasis, and is safe in healthy, cognitively intact older adults.

DESIGN

Four-month, randomized, double-blind, placebo-controlled parallel design.

SUBJECTS/SETTING

Ninety men and women (age range 65 to 84 years) were recruited to a university clinic. Eligibility included those without dementia or depression, not taking psychoactive medications or medications or supplements that alter hemostasis.

INTERVENTION

Ninety subjects were randomly assigned to placebo or a ginkgo biloba-based supplement containing 160 mg ginkgo biloba, 68 mg gotu kola, and 180 mg decosahexaenoic acid per day for 4 months.

MAIN OUTCOME MEASURES

Assessments included: six standardized cognitive function tests, the SF-36 Quality of Life questionnaire, the Platelet Function Analyzer-100 (Dade Behring, Eschbom, Germany), and the monitoring of adverse events.

STATISTICAL ANALYSES

Baseline characteristics and study hypotheses were tested using analysis of covariance. Tests were two-tailed with a 0.05 significance level.

RESULTS

Seventy-eight subjects (87%) completed both baseline and 4-month testing (n=36 in placebo group, n=42 in ginkgo biloba group). At baseline, the participants' cognitive function was above average. One of six cognitive tests indicated significant protocol differences at 4 months (P=0.03), favoring the placebo. There were no significant differences in quality of life, platelet function, or adverse events.

CONCLUSIONS

These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults. However, high baseline scores may have contributed to the null findings. The ginkgo biloba product seems safe and did not alter platelet function, though additional studies are needed to evaluate the interaction of varying doses of ginkgo biloba and ginkgo biloba-containing supplements with medications and supplements that alter hemostasis.

Authors+Show Affiliations

Sport and Cardiovascular Nutrition Program, Department of Radiology, Michigan State University, College of Osteopathic Medicine, East Lansing, MI 48824, USA. joe.carlson@radiology.msu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17324660

Citation

Carlson, Joseph J., et al. "Safety and Efficacy of a Ginkgo Biloba-containing Dietary Supplement On Cognitive Function, Quality of Life, and Platelet Function in Healthy, Cognitively Intact Older Adults." Journal of the American Dietetic Association, vol. 107, no. 3, 2007, pp. 422-32.
Carlson JJ, Farquhar JW, DiNucci E, et al. Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. J Am Diet Assoc. 2007;107(3):422-32.
Carlson, J. J., Farquhar, J. W., DiNucci, E., Ausserer, L., Zehnder, J., Miller, D., ... Haskell, W. L. (2007). Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. Journal of the American Dietetic Association, 107(3), pp. 422-32.
Carlson JJ, et al. Safety and Efficacy of a Ginkgo Biloba-containing Dietary Supplement On Cognitive Function, Quality of Life, and Platelet Function in Healthy, Cognitively Intact Older Adults. J Am Diet Assoc. 2007;107(3):422-32. PubMed PMID: 17324660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Safety and efficacy of a ginkgo biloba-containing dietary supplement on cognitive function, quality of life, and platelet function in healthy, cognitively intact older adults. AU - Carlson,Joseph J, AU - Farquhar,John W, AU - DiNucci,Ellen, AU - Ausserer,Laurie, AU - Zehnder,James, AU - Miller,Donald, AU - Berra,Kathy, AU - Hagerty,Lisa, AU - Haskell,William L, PY - 2005/06/30/received PY - 2007/2/28/pubmed PY - 2007/4/24/medline PY - 2007/2/28/entrez SP - 422 EP - 32 JF - Journal of the American Dietetic Association JO - J Am Diet Assoc VL - 107 IS - 3 N2 - OBJECTIVE: To determine if a ginkgo biloba-containing supplement improves cognitive function and quality of life, alters primary hemostasis, and is safe in healthy, cognitively intact older adults. DESIGN: Four-month, randomized, double-blind, placebo-controlled parallel design. SUBJECTS/SETTING: Ninety men and women (age range 65 to 84 years) were recruited to a university clinic. Eligibility included those without dementia or depression, not taking psychoactive medications or medications or supplements that alter hemostasis. INTERVENTION: Ninety subjects were randomly assigned to placebo or a ginkgo biloba-based supplement containing 160 mg ginkgo biloba, 68 mg gotu kola, and 180 mg decosahexaenoic acid per day for 4 months. MAIN OUTCOME MEASURES: Assessments included: six standardized cognitive function tests, the SF-36 Quality of Life questionnaire, the Platelet Function Analyzer-100 (Dade Behring, Eschbom, Germany), and the monitoring of adverse events. STATISTICAL ANALYSES: Baseline characteristics and study hypotheses were tested using analysis of covariance. Tests were two-tailed with a 0.05 significance level. RESULTS: Seventy-eight subjects (87%) completed both baseline and 4-month testing (n=36 in placebo group, n=42 in ginkgo biloba group). At baseline, the participants' cognitive function was above average. One of six cognitive tests indicated significant protocol differences at 4 months (P=0.03), favoring the placebo. There were no significant differences in quality of life, platelet function, or adverse events. CONCLUSIONS: These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults. However, high baseline scores may have contributed to the null findings. The ginkgo biloba product seems safe and did not alter platelet function, though additional studies are needed to evaluate the interaction of varying doses of ginkgo biloba and ginkgo biloba-containing supplements with medications and supplements that alter hemostasis. SN - 0002-8223 UR - https://www.unboundmedicine.com/medline/citation/17324660/Safety_and_efficacy_of_a_ginkgo_biloba_containing_dietary_supplement_on_cognitive_function_quality_of_life_and_platelet_function_in_healthy_cognitively_intact_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8223(06)02678-2 DB - PRIME DP - Unbound Medicine ER -