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Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle?
Pediatrics. 2007 Mar; 119(3):e754-9.Ped

Abstract

We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment. Acute infection with H. pylori is accompanied by hypochlorhydria, which facilitates the acquisition of other enteropathogens because of removal of the gastric acid barrier, which then results in diarrheal disease and iron-deficiency anemia. This is likely to occur most frequently in developing regions where the prevalence of H. pylori infection is disproportionately high and multiple enteric coinfections are common. The consequent synergistic impact of diarrheal disease and micronutrient deficiency on growth and cognitive function in children has significant public health implications for socioeconomic development in these countries.

Authors+Show Affiliations

School of Medicine, Trinity College Dublin and Dublin Molecular Medicine Centre, Dublin, Ireland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17325213

Citation

Windle, Henry J., et al. "Childhood Helicobacter Pylori Infection and Growth Impairment in Developing Countries: a Vicious Cycle?" Pediatrics, vol. 119, no. 3, 2007, pp. e754-9.
Windle HJ, Kelleher D, Crabtree JE. Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? Pediatrics. 2007;119(3):e754-9.
Windle, H. J., Kelleher, D., & Crabtree, J. E. (2007). Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? Pediatrics, 119(3), e754-9.
Windle HJ, Kelleher D, Crabtree JE. Childhood Helicobacter Pylori Infection and Growth Impairment in Developing Countries: a Vicious Cycle. Pediatrics. 2007;119(3):e754-9. PubMed PMID: 17325213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood Helicobacter pylori infection and growth impairment in developing countries: a vicious cycle? AU - Windle,Henry J, AU - Kelleher,Dermot, AU - Crabtree,Jean E, Y1 - 2007/02/26/ PY - 2007/2/28/pubmed PY - 2007/3/28/medline PY - 2007/2/28/entrez SP - e754 EP - 9 JF - Pediatrics JO - Pediatrics VL - 119 IS - 3 N2 - We hypothesize that infection with the gastric pathogen Helicobacter pylori in children in developing countries is the initiator of a vicious cycle of events that result ultimately in malnutrition and growth impairment. Acute infection with H. pylori is accompanied by hypochlorhydria, which facilitates the acquisition of other enteropathogens because of removal of the gastric acid barrier, which then results in diarrheal disease and iron-deficiency anemia. This is likely to occur most frequently in developing regions where the prevalence of H. pylori infection is disproportionately high and multiple enteric coinfections are common. The consequent synergistic impact of diarrheal disease and micronutrient deficiency on growth and cognitive function in children has significant public health implications for socioeconomic development in these countries. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/17325213/Childhood_Helicobacter_pylori_infection_and_growth_impairment_in_developing_countries:_a_vicious_cycle L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=17325213 DB - PRIME DP - Unbound Medicine ER -