Nitrile-promoted Rh-catalyzed intermolecular hydroacylation of olefins with salicylaldehyde.J Org Chem. 2007 Mar 30; 72(7):2543-6.JO
Rh-catalyzed intermolecular hydroacylation between salicylaldehyde and alkenylnitriles proceeded at room temperature to preferentially give normal-hydroacylated products. Addition of CH3CN and NaOAc accelerated the Rh-catalyzed hydroacylation of monoolefins to exclusively produce the normal-hydroacylated products under mild reaction conditions. Plausible mechanisms for the regioselections are also described.