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Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection.
Exp Biol Med (Maywood) 2007; 232(3):412-9EB

Abstract

This study was designed to determine the effect of selenium (Se) deficiency on the immune response to infection with a virulent strain of influenza virus, influenza A/Puerto Rico/8/34. Previous work in our laboratory demonstrated that Se-deficient mice infected with a mild strain of influenza virus, influenza A/ Bangkok/1/79, developed much more severe lung pathology compared with Se-adequate mice. Immune function was altered in the Se-deficient mice, and the viral genome changed to a more virulent genotype. In this study, we tested whether Se deficiency would have a similar effect on mice infected with a more virulent, mouse-adapted strain of influenza virus. Three-week-old male mice were fed Se-adequate or Se-deficient diet for 4 weeks before inoculation with influenza A/PR8/34. There was no difference in lung influenza viral titer between Se-deficient and Se-adequate mice. Se-deficient mice had less macrophage inflammatory protein 1alpha (MIP-1alpha) and regulated upon activation, normal T cell expressed and secreted (RANTES) production at the transcriptional and protein level in the lung postinfection. Se-deficient mice also had higher levels of IL-2 expression followed by a higher level of IL-4 expression in the lung. At Day 7 postinfection, there was no death in the Se-deficient group compared with 50% of the mice dying in the Se-adequate group. Sequencing of the virus isolated from infected Se-adequate and Se-deficient mice did not detect viral genome mutations in either group. This study demonstrated that Se-deficient mice had an altered immune response to an infection with a virulent strain of influenza virus. This altered immune response was beneficial for protecting the mice from influenza virus-induced mortality.

Authors+Show Affiliations

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17327475

Citation

Li, Wei, and Melinda A. Beck. "Selenium Deficiency Induced an Altered Immune Response and Increased Survival Following Influenza A/Puerto Rico/8/34 Infection." Experimental Biology and Medicine (Maywood, N.J.), vol. 232, no. 3, 2007, pp. 412-9.
Li W, Beck MA. Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection. Exp Biol Med (Maywood). 2007;232(3):412-9.
Li, W., & Beck, M. A. (2007). Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection. Experimental Biology and Medicine (Maywood, N.J.), 232(3), pp. 412-9.
Li W, Beck MA. Selenium Deficiency Induced an Altered Immune Response and Increased Survival Following Influenza A/Puerto Rico/8/34 Infection. Exp Biol Med (Maywood). 2007;232(3):412-9. PubMed PMID: 17327475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selenium deficiency induced an altered immune response and increased survival following influenza A/Puerto Rico/8/34 infection. AU - Li,Wei, AU - Beck,Melinda A, PY - 2007/3/1/pubmed PY - 2007/4/17/medline PY - 2007/3/1/entrez SP - 412 EP - 9 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp. Biol. Med. (Maywood) VL - 232 IS - 3 N2 - This study was designed to determine the effect of selenium (Se) deficiency on the immune response to infection with a virulent strain of influenza virus, influenza A/Puerto Rico/8/34. Previous work in our laboratory demonstrated that Se-deficient mice infected with a mild strain of influenza virus, influenza A/ Bangkok/1/79, developed much more severe lung pathology compared with Se-adequate mice. Immune function was altered in the Se-deficient mice, and the viral genome changed to a more virulent genotype. In this study, we tested whether Se deficiency would have a similar effect on mice infected with a more virulent, mouse-adapted strain of influenza virus. Three-week-old male mice were fed Se-adequate or Se-deficient diet for 4 weeks before inoculation with influenza A/PR8/34. There was no difference in lung influenza viral titer between Se-deficient and Se-adequate mice. Se-deficient mice had less macrophage inflammatory protein 1alpha (MIP-1alpha) and regulated upon activation, normal T cell expressed and secreted (RANTES) production at the transcriptional and protein level in the lung postinfection. Se-deficient mice also had higher levels of IL-2 expression followed by a higher level of IL-4 expression in the lung. At Day 7 postinfection, there was no death in the Se-deficient group compared with 50% of the mice dying in the Se-adequate group. Sequencing of the virus isolated from infected Se-adequate and Se-deficient mice did not detect viral genome mutations in either group. This study demonstrated that Se-deficient mice had an altered immune response to an infection with a virulent strain of influenza virus. This altered immune response was beneficial for protecting the mice from influenza virus-induced mortality. SN - 1535-3702 UR - https://www.unboundmedicine.com/medline/citation/17327475/Selenium_deficiency_induced_an_altered_immune_response_and_increased_survival_following_influenza_A/Puerto_Rico/8/34_infection_ DB - PRIME DP - Unbound Medicine ER -