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Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes.
Eur J Clin Nutr. 2008 Mar; 62(3):419-29.EJ

Abstract

OBJECTIVE

To measure effects of fish oil supplements on lipoprotein subclasses by nuclear magnetic resonance (NMR) in subjects with type II diabetes and relate them to insulin sensitivity.

DESIGN

Two-armed, parallel, placebo-controlled, randomized.

SUBJECTS

Normotriglyceridemic subjects with type II diabetes without insulin treatment were given either fish oil (n=12, median intake 5.9 g/day total n-3 fatty acids (FA) (1.8 g 20:5n-3, 3.0 g 22:6n-3)) or corn oil (n=14, 8.5 g/day 18:2n-6 FA).

METHODS

Size and concentration of lipoproteins subclasses were measured by NMR, insulin sensitivity by hyperinsulinemic, isoglycemic clamps.

RESULTS

After 9 weeks, there were differences between those treated with fish and corn oil with respect to very low-density lipoprotein (VLDL) size (median -15 vs +0.6%, P=0.001), particle concentrations of large VLDL (-99 vs -4.1%, P=0.041) and small high-density lipoprotein (HDL) (-12 vs +10%, P=0.051). Compared with corn oil fish oil tended to increase HDL size and small low-density lipoprotein (LDL) concentration (P=0.063 and 0.068, respectively, for differences between groups). There was no effect on oxidized LDL. Insulin sensitivity (glucose utilization) decreased in the fish oil group compared with the corn oil group (P=0.049). The decrease in insulin sensitivity did not correlate with the effects on lipoprotein subclasses.

CONCLUSIONS

A high intake of n-3 FA exerts effects on several lipoprotein subclasses without obvious influence from changes in insulin sensitivity.

Authors+Show Affiliations

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17327864

Citation

Mostad, I L., et al. "Effects of Marine N-3 Fatty Acid Supplementation On Lipoprotein Subclasses Measured By Nuclear Magnetic Resonance in Subjects With Type II Diabetes." European Journal of Clinical Nutrition, vol. 62, no. 3, 2008, pp. 419-29.
Mostad IL, Bjerve KS, Lydersen S, et al. Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes. Eur J Clin Nutr. 2008;62(3):419-29.
Mostad, I. L., Bjerve, K. S., Lydersen, S., & Grill, V. (2008). Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes. European Journal of Clinical Nutrition, 62(3), 419-29.
Mostad IL, et al. Effects of Marine N-3 Fatty Acid Supplementation On Lipoprotein Subclasses Measured By Nuclear Magnetic Resonance in Subjects With Type II Diabetes. Eur J Clin Nutr. 2008;62(3):419-29. PubMed PMID: 17327864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of marine n-3 fatty acid supplementation on lipoprotein subclasses measured by nuclear magnetic resonance in subjects with type II diabetes. AU - Mostad,I L, AU - Bjerve,K S, AU - Lydersen,S, AU - Grill,V, Y1 - 2007/02/28/ PY - 2007/3/1/pubmed PY - 2008/7/2/medline PY - 2007/3/1/entrez SP - 419 EP - 29 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 3 N2 - OBJECTIVE: To measure effects of fish oil supplements on lipoprotein subclasses by nuclear magnetic resonance (NMR) in subjects with type II diabetes and relate them to insulin sensitivity. DESIGN: Two-armed, parallel, placebo-controlled, randomized. SUBJECTS: Normotriglyceridemic subjects with type II diabetes without insulin treatment were given either fish oil (n=12, median intake 5.9 g/day total n-3 fatty acids (FA) (1.8 g 20:5n-3, 3.0 g 22:6n-3)) or corn oil (n=14, 8.5 g/day 18:2n-6 FA). METHODS: Size and concentration of lipoproteins subclasses were measured by NMR, insulin sensitivity by hyperinsulinemic, isoglycemic clamps. RESULTS: After 9 weeks, there were differences between those treated with fish and corn oil with respect to very low-density lipoprotein (VLDL) size (median -15 vs +0.6%, P=0.001), particle concentrations of large VLDL (-99 vs -4.1%, P=0.041) and small high-density lipoprotein (HDL) (-12 vs +10%, P=0.051). Compared with corn oil fish oil tended to increase HDL size and small low-density lipoprotein (LDL) concentration (P=0.063 and 0.068, respectively, for differences between groups). There was no effect on oxidized LDL. Insulin sensitivity (glucose utilization) decreased in the fish oil group compared with the corn oil group (P=0.049). The decrease in insulin sensitivity did not correlate with the effects on lipoprotein subclasses. CONCLUSIONS: A high intake of n-3 FA exerts effects on several lipoprotein subclasses without obvious influence from changes in insulin sensitivity. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17327864/Effects_of_marine_n_3_fatty_acid_supplementation_on_lipoprotein_subclasses_measured_by_nuclear_magnetic_resonance_in_subjects_with_type_II_diabetes_ L2 - https://doi.org/10.1038/sj.ejcn.1602703 DB - PRIME DP - Unbound Medicine ER -