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Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study.
Eur J Clin Nutr. 2008 Feb; 62(2):203-9.EJ

Abstract

OBJECTIVES

To compare the lipid profiles of exclusively breastfed and mixed-fed term healthy infants in the first 6 months of life.

DESIGN

Prospective comparative study.

SETTING

Study was carried out in a tertiary care hospital.

SUBJECTS

Four hundred consecutive term healthy infants, 200 on exclusive breastfeeding (group 1) and 200 receiving mixed feeding (group 2) were recruited at 14 weeks of age. At 6 months, 149 and 150 mother-infant pairs were followed up in groups 1 and 2, respectively.

METHODS

Anthropometric measures of the mother and baby were recorded. Serum lipid levels of the mother and babies were determined at 14 weeks. Babies were followed up till 6 months and their lipid levels were determined again at 6 months. Statistical analysis was carried out using SPSS.

RESULTS

Two groups were comparable in birth weight and maternal characteristics (P>0.05). Weight and head circumference were significantly more in the breastfed group at 14 weeks as well as at 6 months (P<0.001). Mean total cholesterol (TC) was 205.27+/-47.31 and 176.55+/-32.01 mg/dl in groups 1 and 2, respectively at 14 weeks (CI=20.77-36.66, P<0.001). At 6 months TC was 192.79+/-40.52 and 161.05+/-22.53 mg/dl in the two groups (CI=24.26-39.22, P<0.001). Change in total cholesterol from 14 weeks to 6 months was also significant in both groups (P<0.001). Low-density lipoprotein cholesterol (LDL-C) and triglycerides were significantly higher in the breastfed groups at 14 weeks and 6 months. The high-density lipoprotein cholesterol (HDL-C)/LDL-C significantly improved at 6 months in exclusively breastfed group (P=0.045). A positive correlation was found only at 14 weeks between mother's TC and baby's TC (r=0.332), mother's LDL-C with baby's LDL-C (r=0.223) in mixed fed group.

CONCLUSION

Breastfed babies have significantly higher TC and LDL-C compared to mixed fed babies in the first 6 months of life with improving HDL-C/LDL-C ratio at 6 months.

SPONSORSHIP

None.

Authors+Show Affiliations

Department of Pediatrics and Biochemistry, University College of Medical Sciences, and Guru Tegh Bahadur Hospital, Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17327867

Citation

Harit, D, et al. "Lipid Profile of Term Infants On Exclusive Breastfeeding and Mixed Feeding: a Comparative Study." European Journal of Clinical Nutrition, vol. 62, no. 2, 2008, pp. 203-9.
Harit D, Faridi MM, Aggarwal A, et al. Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study. Eur J Clin Nutr. 2008;62(2):203-9.
Harit, D., Faridi, M. M., Aggarwal, A., & Sharma, S. B. (2008). Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study. European Journal of Clinical Nutrition, 62(2), 203-9.
Harit D, et al. Lipid Profile of Term Infants On Exclusive Breastfeeding and Mixed Feeding: a Comparative Study. Eur J Clin Nutr. 2008;62(2):203-9. PubMed PMID: 17327867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study. AU - Harit,D, AU - Faridi,M M A, AU - Aggarwal,A, AU - Sharma,S B, Y1 - 2007/02/28/ PY - 2007/3/1/pubmed PY - 2008/5/13/medline PY - 2007/3/1/entrez SP - 203 EP - 9 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 62 IS - 2 N2 - OBJECTIVES: To compare the lipid profiles of exclusively breastfed and mixed-fed term healthy infants in the first 6 months of life. DESIGN: Prospective comparative study. SETTING: Study was carried out in a tertiary care hospital. SUBJECTS: Four hundred consecutive term healthy infants, 200 on exclusive breastfeeding (group 1) and 200 receiving mixed feeding (group 2) were recruited at 14 weeks of age. At 6 months, 149 and 150 mother-infant pairs were followed up in groups 1 and 2, respectively. METHODS: Anthropometric measures of the mother and baby were recorded. Serum lipid levels of the mother and babies were determined at 14 weeks. Babies were followed up till 6 months and their lipid levels were determined again at 6 months. Statistical analysis was carried out using SPSS. RESULTS: Two groups were comparable in birth weight and maternal characteristics (P>0.05). Weight and head circumference were significantly more in the breastfed group at 14 weeks as well as at 6 months (P<0.001). Mean total cholesterol (TC) was 205.27+/-47.31 and 176.55+/-32.01 mg/dl in groups 1 and 2, respectively at 14 weeks (CI=20.77-36.66, P<0.001). At 6 months TC was 192.79+/-40.52 and 161.05+/-22.53 mg/dl in the two groups (CI=24.26-39.22, P<0.001). Change in total cholesterol from 14 weeks to 6 months was also significant in both groups (P<0.001). Low-density lipoprotein cholesterol (LDL-C) and triglycerides were significantly higher in the breastfed groups at 14 weeks and 6 months. The high-density lipoprotein cholesterol (HDL-C)/LDL-C significantly improved at 6 months in exclusively breastfed group (P=0.045). A positive correlation was found only at 14 weeks between mother's TC and baby's TC (r=0.332), mother's LDL-C with baby's LDL-C (r=0.223) in mixed fed group. CONCLUSION: Breastfed babies have significantly higher TC and LDL-C compared to mixed fed babies in the first 6 months of life with improving HDL-C/LDL-C ratio at 6 months. SPONSORSHIP: None. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/17327867/Lipid_profile_of_term_infants_on_exclusive_breastfeeding_and_mixed_feeding:_a_comparative_study_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602692 DB - PRIME DP - Unbound Medicine ER -