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Coeliac disease and risk of schizophrenia and other psychosis: a general population cohort study.

Abstract

OBJECTIVE

Several case reports and a recent study on coeliac disease (CD) and family history of schizophrenia indicate a link between CD and schizophrenia. The objective of our study was to determine the risk of non-affective psychosis in patients with CD in a national general population cohort.

MATERIAL AND METHODS

We identified 14,003 individuals with a diagnosis of CD in the Swedish national inpatient register between 1973 and 2003. From the population register, Statistics Sweden then identified five reference individuals matched for age and calendar year at diagnosis, gender and county (n=68,125). Only individuals with more than one year of follow-up after the CD diagnosis was first recorded or a corresponding date in reference individuals were included in the analyses. The risk of subsequent non-affective psychosis in individuals with CD was estimated by Cox regression.

RESULTS

CD was associated with a statistically significant increased risk of any non-affective psychosis (hazard ratio (HR)=1.55; 95% CI=1.16-2.06; p=0.003) (65 positive events in 14,003 individuals with CD and 216 positive events in 68,125 individuals without CD); this increased risk was largely due to the association with non-schizophrenic non-affective psychosis (HR=1.61; 95% CI=1.19-2.20; p=0.002: 56 positive events in individuals with CD and 180 among reference individuals). There was no statistically significant association with subsequent schizophrenia (HR=1.43; 95%=0.77-2.67; p=0.261: 14 positive events in individuals with CD and 50 among reference individuals).

CONCLUSIONS

Individuals with CD may be at increased risk of non-affective psychosis.

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  • Authors+Show Affiliations

    ,

    Department of Paediatrics, Orebro University Hospital, Sweden. jonasludvigsson@yahoo.com

    , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Celiac Disease
    Child
    Child, Preschool
    Female
    Follow-Up Studies
    Humans
    Incidence
    Infant
    Infant, Newborn
    Male
    Middle Aged
    Population Surveillance
    Prognosis
    Psychotic Disorders
    Retrospective Studies
    Risk Factors
    Schizophrenia
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17327937

    Citation

    Ludvigsson, Jonas F., et al. "Coeliac Disease and Risk of Schizophrenia and Other Psychosis: a General Population Cohort Study." Scandinavian Journal of Gastroenterology, vol. 42, no. 2, 2007, pp. 179-85.
    Ludvigsson JF, Osby U, Ekbom A, et al. Coeliac disease and risk of schizophrenia and other psychosis: a general population cohort study. Scand J Gastroenterol. 2007;42(2):179-85.
    Ludvigsson, J. F., Osby, U., Ekbom, A., & Montgomery, S. M. (2007). Coeliac disease and risk of schizophrenia and other psychosis: a general population cohort study. Scandinavian Journal of Gastroenterology, 42(2), pp. 179-85.
    Ludvigsson JF, et al. Coeliac Disease and Risk of Schizophrenia and Other Psychosis: a General Population Cohort Study. Scand J Gastroenterol. 2007;42(2):179-85. PubMed PMID: 17327937.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Coeliac disease and risk of schizophrenia and other psychosis: a general population cohort study. AU - Ludvigsson,Jonas F, AU - Osby,Urban, AU - Ekbom,Anders, AU - Montgomery,Scott M, PY - 2007/3/1/pubmed PY - 2007/3/30/medline PY - 2007/3/1/entrez SP - 179 EP - 85 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 42 IS - 2 N2 - OBJECTIVE: Several case reports and a recent study on coeliac disease (CD) and family history of schizophrenia indicate a link between CD and schizophrenia. The objective of our study was to determine the risk of non-affective psychosis in patients with CD in a national general population cohort. MATERIAL AND METHODS: We identified 14,003 individuals with a diagnosis of CD in the Swedish national inpatient register between 1973 and 2003. From the population register, Statistics Sweden then identified five reference individuals matched for age and calendar year at diagnosis, gender and county (n=68,125). Only individuals with more than one year of follow-up after the CD diagnosis was first recorded or a corresponding date in reference individuals were included in the analyses. The risk of subsequent non-affective psychosis in individuals with CD was estimated by Cox regression. RESULTS: CD was associated with a statistically significant increased risk of any non-affective psychosis (hazard ratio (HR)=1.55; 95% CI=1.16-2.06; p=0.003) (65 positive events in 14,003 individuals with CD and 216 positive events in 68,125 individuals without CD); this increased risk was largely due to the association with non-schizophrenic non-affective psychosis (HR=1.61; 95% CI=1.19-2.20; p=0.002: 56 positive events in individuals with CD and 180 among reference individuals). There was no statistically significant association with subsequent schizophrenia (HR=1.43; 95%=0.77-2.67; p=0.261: 14 positive events in individuals with CD and 50 among reference individuals). CONCLUSIONS: Individuals with CD may be at increased risk of non-affective psychosis. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/17327937/Coeliac_disease_and_risk_of_schizophrenia_and_other_psychosis:_a_general_population_cohort_study_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520600863472 DB - PRIME DP - Unbound Medicine ER -