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Rubinstein-Taybi syndrome in children with tethered spinal cord.
J Neurosurg. 2006 Oct; 105(4 Suppl):261-4.JN

Abstract

OBJECT

The authors identified eight patients with Rubinstein-Taybi syndrome (RTS) and examined how the underlying conditions of this syndrome can impede the detection of symptoms associated with a tethered spinal cord. They also reviewed the literature and did not find any published series describing such an association with this syndrome.

METHODS

In this retrospective review, the authors report the diagnosis, treatment, and outcome of tethered spinal cord in eight children (age range 2-14 years) with RTS. The patients presented between 1995 and 2003 with neurogenic bladder, decreased activity, gait disturbance, and low-back pain. The children were examined using whole-spine magnetic resonance (MR) imaging and, in recent years, their spinal cord movement was assessed using cine MR imaging. After undergoing lumbar laminectomy and spinal cord untethering procedures, six patients experienced improvement in symptoms associated with tethered spinal cord such as pain, urinary tract infection, incontinence, spasticity, and neurogenic bladder.

CONCLUSIONS

Although some underlying conditions of RTS may mask the symptoms of a tethered spinal cord in children, careful attention to the patient's medical history as provided by his or her parents may aid in early diagnosis, evaluation, and treatment, thus preventing further neurological deterioration and leading to improved outcomes.

Authors+Show Affiliations

Department of Neurosurgery, Cincinnati Children's Hospital Medical Center, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17328274

Citation

Tanaka, Tomoko, et al. "Rubinstein-Taybi Syndrome in Children With Tethered Spinal Cord." Journal of Neurosurgery, vol. 105, no. 4 Suppl, 2006, pp. 261-4.
Tanaka T, Ling BC, Rubinstein JH, et al. Rubinstein-Taybi syndrome in children with tethered spinal cord. J Neurosurg. 2006;105(4 Suppl):261-4.
Tanaka, T., Ling, B. C., Rubinstein, J. H., & Crone, K. R. (2006). Rubinstein-Taybi syndrome in children with tethered spinal cord. Journal of Neurosurgery, 105(4 Suppl), 261-4.
Tanaka T, et al. Rubinstein-Taybi Syndrome in Children With Tethered Spinal Cord. J Neurosurg. 2006;105(4 Suppl):261-4. PubMed PMID: 17328274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rubinstein-Taybi syndrome in children with tethered spinal cord. AU - Tanaka,Tomoko, AU - Ling,Benjamin C, AU - Rubinstein,Jack H, AU - Crone,Kerry R, PY - 2007/3/3/pubmed PY - 2007/3/14/medline PY - 2007/3/3/entrez SP - 261 EP - 4 JF - Journal of neurosurgery JO - J. Neurosurg. VL - 105 IS - 4 Suppl N2 - OBJECT: The authors identified eight patients with Rubinstein-Taybi syndrome (RTS) and examined how the underlying conditions of this syndrome can impede the detection of symptoms associated with a tethered spinal cord. They also reviewed the literature and did not find any published series describing such an association with this syndrome. METHODS: In this retrospective review, the authors report the diagnosis, treatment, and outcome of tethered spinal cord in eight children (age range 2-14 years) with RTS. The patients presented between 1995 and 2003 with neurogenic bladder, decreased activity, gait disturbance, and low-back pain. The children were examined using whole-spine magnetic resonance (MR) imaging and, in recent years, their spinal cord movement was assessed using cine MR imaging. After undergoing lumbar laminectomy and spinal cord untethering procedures, six patients experienced improvement in symptoms associated with tethered spinal cord such as pain, urinary tract infection, incontinence, spasticity, and neurogenic bladder. CONCLUSIONS: Although some underlying conditions of RTS may mask the symptoms of a tethered spinal cord in children, careful attention to the patient's medical history as provided by his or her parents may aid in early diagnosis, evaluation, and treatment, thus preventing further neurological deterioration and leading to improved outcomes. SN - 0022-3085 UR - https://www.unboundmedicine.com/medline/citation/17328274/Rubinstein_Taybi_syndrome_in_children_with_tethered_spinal_cord_ L2 - https://thejns.org/doi/10.3171/ped.2006.105.4.261 DB - PRIME DP - Unbound Medicine ER -