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Papillary breast lesions diagnosed on cytology. Profile of 65 cases.
Acta Cytol. 2007 Jan-Feb; 51(1):3-8.AC

Abstract

OBJECTIVE

To analyze the cytologic features of nipple discharge and fine needle aspiration (FNA) cytologic smears from breast lesions reported as showing papillary features and to correlate them with histopathologic features.

STUDY DESIGN

The study group consisted of FNA smears and/or nipple discharge smears from 65 breast lesions diagnosed on cytology as duct papilloma, papillary lesion, fibrocystic condition, fibroadenoma, papillary neoplasm or papillary carcinoma. Cytomorphologic features assessed included cellularity, cell pattern (clusters, papillary, 3-dimensionality, etc.) and cell characteristics (monomorphism, pleomorphism, apocrine change, plasmacytoid features). Histological material was available for review and cytohistologic correlation in all cases.

RESULTS

Forty-six specimens were FNA smears, and 16 were nipple discharge smears; in 3 cases FNA and nipple discharge cytologic smears were available for review. Cytologic study could predict the presence of a papillary pattern in all neoplasms with pure or focal papillary differentiation. There was an overlap in cytomorphologic features between papillary and nonpapillary benign lesions as well as between benign and malignant papillary neoplasms. Frank blood in the aspirate, cell dissociation and atypia, however, were more frequent in the last.

CONCLUSION

Overlap of cytologic features in nonneoplastic and neoplastic benign papillary lesions and between benign and malignant papillary neoplasms necessitates histologic evaluation in all cases diagnosed as papillary on cytology. Since 49.2% of lesions showing papillary features on cytology prove to be malignant, all cases reported as papillary on cytology should be excised urgently for histologic assessment.

Authors+Show Affiliations

Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. gitajayaram@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

17328487

Citation

Jayaram, Gita, et al. "Papillary Breast Lesions Diagnosed On Cytology. Profile of 65 Cases." Acta Cytologica, vol. 51, no. 1, 2007, pp. 3-8.
Jayaram G, Elsayed EM, Yaccob RB. Papillary breast lesions diagnosed on cytology. Profile of 65 cases. Acta Cytol. 2007;51(1):3-8.
Jayaram, G., Elsayed, E. M., & Yaccob, R. B. (2007). Papillary breast lesions diagnosed on cytology. Profile of 65 cases. Acta Cytologica, 51(1), 3-8.
Jayaram G, Elsayed EM, Yaccob RB. Papillary Breast Lesions Diagnosed On Cytology. Profile of 65 Cases. Acta Cytol. 2007 Jan-Feb;51(1):3-8. PubMed PMID: 17328487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Papillary breast lesions diagnosed on cytology. Profile of 65 cases. AU - Jayaram,Gita, AU - Elsayed,Elnazir Mohamed, AU - Yaccob,Roshidah Binti, PY - 2007/3/3/pubmed PY - 2007/3/14/medline PY - 2007/3/3/entrez SP - 3 EP - 8 JF - Acta cytologica JO - Acta Cytol VL - 51 IS - 1 N2 - OBJECTIVE: To analyze the cytologic features of nipple discharge and fine needle aspiration (FNA) cytologic smears from breast lesions reported as showing papillary features and to correlate them with histopathologic features. STUDY DESIGN: The study group consisted of FNA smears and/or nipple discharge smears from 65 breast lesions diagnosed on cytology as duct papilloma, papillary lesion, fibrocystic condition, fibroadenoma, papillary neoplasm or papillary carcinoma. Cytomorphologic features assessed included cellularity, cell pattern (clusters, papillary, 3-dimensionality, etc.) and cell characteristics (monomorphism, pleomorphism, apocrine change, plasmacytoid features). Histological material was available for review and cytohistologic correlation in all cases. RESULTS: Forty-six specimens were FNA smears, and 16 were nipple discharge smears; in 3 cases FNA and nipple discharge cytologic smears were available for review. Cytologic study could predict the presence of a papillary pattern in all neoplasms with pure or focal papillary differentiation. There was an overlap in cytomorphologic features between papillary and nonpapillary benign lesions as well as between benign and malignant papillary neoplasms. Frank blood in the aspirate, cell dissociation and atypia, however, were more frequent in the last. CONCLUSION: Overlap of cytologic features in nonneoplastic and neoplastic benign papillary lesions and between benign and malignant papillary neoplasms necessitates histologic evaluation in all cases diagnosed as papillary on cytology. Since 49.2% of lesions showing papillary features on cytology prove to be malignant, all cases reported as papillary on cytology should be excised urgently for histologic assessment. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/17328487/Papillary_breast_lesions_diagnosed_on_cytology__Profile_of_65_cases_ L2 - https://www.karger.com?DOI=10.1159/000325674 DB - PRIME DP - Unbound Medicine ER -