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Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity.
J Neurol Sci. 2007 Apr 15; 255(1-2):42-9.JN

Abstract

There is evidence that most forms of ischaemic stroke (IS) result from synergistic effects of the modifiable predisposing factors and multiple genes. In the present work, we report results of case-control study of IS association with apolipoprotein E gene (APOE) (promoter and coding polymorphisms) and lipoprotein lipase gene (LPL) (presence/absence of a HindIII cutting site). We studied 107 unrelated patients of Yakut ethnicity (69 men and 38 women, mean age 58.4+/-11.5 years) with first-ever IS in carotid/middle cerebral artery regions. The control group included 101 subjects of the same ethnicity (61 men and 40 women, mean age 57.6+/-11.6 years) free of clinically detectable cerebrovascular disease, and without any history of stroke. A positive association of IS with APOE -427T allele (p=0.0012, OR=3.99) and -427T/T genotype (p=0.0005, OR=4.96) and a negative association with -427C allele (p=0.0012, OR=0.25), -427T/C genotype (p=0.0003, OR=0.18), epsilon2 allele (p=0.018, OR=0.35), epsilon2/3 genotype (p=0.017, OR=0.28) and -491A/-427C/epsilon2 haplotype (p=0.0026, OR=0.18) were observed. For atherothrombotic subgroup the same allele and genotype associations were found plus association with APOE -491A allele (p=0.026, OR=3.98). No reliable IS associations were found with LPL T+495G (HindIII) polymorphism. An association of APOE promoter polymorphisms (A-491T, T-427C) with an IS is shown in our study for the first time. Our study provides evidence for the role of APOE gene as a prognostic genetic marker for IS, especially for its atherothrombotic subtype.

Authors+Show Affiliations

Institute of Experimental Cardiology, Cardiology Research Center, 3rd Cherepkovskaya ul., 15, 121552 Moscow, Russian Federation.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17328917

Citation

Parfenov, Michael G., et al. "Polymorphism of Apolipoprotein E (APOE) and Lipoprotein Lipase (LPL) Genes and Ischaemic Stroke in Individuals of Yakut Ethnicity." Journal of the Neurological Sciences, vol. 255, no. 1-2, 2007, pp. 42-9.
Parfenov MG, Nikolaeva TY, Sudomoina MA, et al. Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity. J Neurol Sci. 2007;255(1-2):42-9.
Parfenov, M. G., Nikolaeva, T. Y., Sudomoina, M. A., Fedorova, S. A., Guekht, A. B., Gusev, E. I., & Favorova, O. O. (2007). Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity. Journal of the Neurological Sciences, 255(1-2), 42-9.
Parfenov MG, et al. Polymorphism of Apolipoprotein E (APOE) and Lipoprotein Lipase (LPL) Genes and Ischaemic Stroke in Individuals of Yakut Ethnicity. J Neurol Sci. 2007 Apr 15;255(1-2):42-9. PubMed PMID: 17328917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity. AU - Parfenov,Michael G, AU - Nikolaeva,Tatyana Y, AU - Sudomoina,Marina A, AU - Fedorova,Sardana A, AU - Guekht,Alla B, AU - Gusev,Eugene I, AU - Favorova,Olga O, Y1 - 2007/02/27/ PY - 2006/06/04/received PY - 2006/12/18/revised PY - 2007/01/25/accepted PY - 2007/3/3/pubmed PY - 2007/6/6/medline PY - 2007/3/3/entrez SP - 42 EP - 9 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 255 IS - 1-2 N2 - There is evidence that most forms of ischaemic stroke (IS) result from synergistic effects of the modifiable predisposing factors and multiple genes. In the present work, we report results of case-control study of IS association with apolipoprotein E gene (APOE) (promoter and coding polymorphisms) and lipoprotein lipase gene (LPL) (presence/absence of a HindIII cutting site). We studied 107 unrelated patients of Yakut ethnicity (69 men and 38 women, mean age 58.4+/-11.5 years) with first-ever IS in carotid/middle cerebral artery regions. The control group included 101 subjects of the same ethnicity (61 men and 40 women, mean age 57.6+/-11.6 years) free of clinically detectable cerebrovascular disease, and without any history of stroke. A positive association of IS with APOE -427T allele (p=0.0012, OR=3.99) and -427T/T genotype (p=0.0005, OR=4.96) and a negative association with -427C allele (p=0.0012, OR=0.25), -427T/C genotype (p=0.0003, OR=0.18), epsilon2 allele (p=0.018, OR=0.35), epsilon2/3 genotype (p=0.017, OR=0.28) and -491A/-427C/epsilon2 haplotype (p=0.0026, OR=0.18) were observed. For atherothrombotic subgroup the same allele and genotype associations were found plus association with APOE -491A allele (p=0.026, OR=3.98). No reliable IS associations were found with LPL T+495G (HindIII) polymorphism. An association of APOE promoter polymorphisms (A-491T, T-427C) with an IS is shown in our study for the first time. Our study provides evidence for the role of APOE gene as a prognostic genetic marker for IS, especially for its atherothrombotic subtype. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/17328917/Polymorphism_of_apolipoprotein_E__APOE__and_lipoprotein_lipase__LPL__genes_and_ischaemic_stroke_in_individuals_of_Yakut_ethnicity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(07)00093-7 DB - PRIME DP - Unbound Medicine ER -