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Early infections of Toxoplasma gondii and the later development of schizophrenia.
Schizophr Bull 2007; 33(3):741-4SB

Abstract

Early exposure to several infectious agents has been associated with the later development of schizophrenia. Two recent studies assessed in utero or early postnatal exposure to Toxoplasma gondii. In one study of 63 individuals, who developed schizophrenia spectrum disorders, maternal sera obtained during pregnancy showed an increased risk (OR 2.61) of having IgG antibodies to T. gondii. In the other study of 71 individuals who developed schizophrenia, sera obtained shortly after birth also showed an increased risk (OR 1.79) of having IgG antibodies to T. gondii. Causal linking mechanisms are at present speculative but include possible direct effects of maternal IgG on the developing central nervous system (CNS) of the offspring. Additional studies are underway.

Authors+Show Affiliations

The National Centre for Register-based Research, University of Aarhus, Taasingegade 1, 8000 Aarhus C, Denmark. pbm@ncrr.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17329231

Citation

Mortensen, Preben Bo, et al. "Early Infections of Toxoplasma Gondii and the Later Development of Schizophrenia." Schizophrenia Bulletin, vol. 33, no. 3, 2007, pp. 741-4.
Mortensen PB, Nørgaard-Pedersen B, Waltoft BL, et al. Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophr Bull. 2007;33(3):741-4.
Mortensen, P. B., Nørgaard-Pedersen, B., Waltoft, B. L., Sørensen, T. L., Hougaard, D., & Yolken, R. H. (2007). Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophrenia Bulletin, 33(3), pp. 741-4.
Mortensen PB, et al. Early Infections of Toxoplasma Gondii and the Later Development of Schizophrenia. Schizophr Bull. 2007;33(3):741-4. PubMed PMID: 17329231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early infections of Toxoplasma gondii and the later development of schizophrenia. AU - Mortensen,Preben Bo, AU - Nørgaard-Pedersen,Bent, AU - Waltoft,Berit L, AU - Sørensen,Tina L, AU - Hougaard,David, AU - Yolken,Robert H, Y1 - 2007/02/28/ PY - 2007/3/3/pubmed PY - 2007/8/19/medline PY - 2007/3/3/entrez SP - 741 EP - 4 JF - Schizophrenia bulletin JO - Schizophr Bull VL - 33 IS - 3 N2 - Early exposure to several infectious agents has been associated with the later development of schizophrenia. Two recent studies assessed in utero or early postnatal exposure to Toxoplasma gondii. In one study of 63 individuals, who developed schizophrenia spectrum disorders, maternal sera obtained during pregnancy showed an increased risk (OR 2.61) of having IgG antibodies to T. gondii. In the other study of 71 individuals who developed schizophrenia, sera obtained shortly after birth also showed an increased risk (OR 1.79) of having IgG antibodies to T. gondii. Causal linking mechanisms are at present speculative but include possible direct effects of maternal IgG on the developing central nervous system (CNS) of the offspring. Additional studies are underway. SN - 0586-7614 UR - https://www.unboundmedicine.com/medline/citation/17329231/Early_infections_of_Toxoplasma_gondii_and_the_later_development_of_schizophrenia_ L2 - https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/sbm009 DB - PRIME DP - Unbound Medicine ER -