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A prospective study of dairy foods intake and anovulatory infertility.

Abstract

BACKGROUND

Dairy foods and lactose may impair fertility by affecting ovulatory function. Yet, few studies have been conducted in humans and their results are inconsistent. We evaluated whether intake of dairy foods was associated with anovulatory infertility and whether this association differed according to fat content.

METHODS

We prospectively followed 18,555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant during an 8-year period. Diet was assessed twice during the study using food-frequency questionnaires.

RESULTS

During follow-up, 438 women reported infertility due to an ovulatory disorder. The multivariate-adjusted relative risks (RR) [95% confidence interval (CI); P, trend] of anovulatory infertility comparing women consuming > or = 2 servings per day to women consuming < or = 1 serving per week was 1.85 (1.24-2.77; 0.002) for low-fat dairy foods. The RR (95% CI; P, trend) comparing women consuming > or = 1 serving per day of high-fat dairy foods to those consuming < or = 1 serving per week was 0.73 (0.52-1.01; 0.01). There was an inverse association between dairy fat intake and anovulatory infertility (P, trend = 0.05). Intakes of lactose, calcium, phosphorus and vitamin D were unrelated to anovulatory infertility.

CONCLUSIONS

High intake of low-fat dairy foods may increase the risk of anovulatory infertility whereas intake of high-fat dairy foods may decrease this risk. Further, lactose (the main carbohydrate in milk and dairy products) may not affect fertility within the usual range of intake levels in humans.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. jchavarr@hsph.harvard.edu

    , ,

    Source

    Human reproduction (Oxford, England) 22:5 2007 May pg 1340-7

    MeSH

    Adult
    Anovulation
    Cohort Studies
    Dairy Products
    Diet Surveys
    Dietary Fats
    Female
    Humans
    Infertility, Female
    Prospective Studies
    Risk

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17329264

    Citation

    Chavarro, J E., et al. "A Prospective Study of Dairy Foods Intake and Anovulatory Infertility." Human Reproduction (Oxford, England), vol. 22, no. 5, 2007, pp. 1340-7.
    Chavarro JE, Rich-Edwards JW, Rosner B, et al. A prospective study of dairy foods intake and anovulatory infertility. Hum Reprod. 2007;22(5):1340-7.
    Chavarro, J. E., Rich-Edwards, J. W., Rosner, B., & Willett, W. C. (2007). A prospective study of dairy foods intake and anovulatory infertility. Human Reproduction (Oxford, England), 22(5), pp. 1340-7.
    Chavarro JE, et al. A Prospective Study of Dairy Foods Intake and Anovulatory Infertility. Hum Reprod. 2007;22(5):1340-7. PubMed PMID: 17329264.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of dairy foods intake and anovulatory infertility. AU - Chavarro,J E, AU - Rich-Edwards,J W, AU - Rosner,B, AU - Willett,W C, Y1 - 2007/02/28/ PY - 2007/3/3/pubmed PY - 2007/7/10/medline PY - 2007/3/3/entrez SP - 1340 EP - 7 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 22 IS - 5 N2 - BACKGROUND: Dairy foods and lactose may impair fertility by affecting ovulatory function. Yet, few studies have been conducted in humans and their results are inconsistent. We evaluated whether intake of dairy foods was associated with anovulatory infertility and whether this association differed according to fat content. METHODS: We prospectively followed 18,555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant during an 8-year period. Diet was assessed twice during the study using food-frequency questionnaires. RESULTS: During follow-up, 438 women reported infertility due to an ovulatory disorder. The multivariate-adjusted relative risks (RR) [95% confidence interval (CI); P, trend] of anovulatory infertility comparing women consuming > or = 2 servings per day to women consuming < or = 1 serving per week was 1.85 (1.24-2.77; 0.002) for low-fat dairy foods. The RR (95% CI; P, trend) comparing women consuming > or = 1 serving per day of high-fat dairy foods to those consuming < or = 1 serving per week was 0.73 (0.52-1.01; 0.01). There was an inverse association between dairy fat intake and anovulatory infertility (P, trend = 0.05). Intakes of lactose, calcium, phosphorus and vitamin D were unrelated to anovulatory infertility. CONCLUSIONS: High intake of low-fat dairy foods may increase the risk of anovulatory infertility whereas intake of high-fat dairy foods may decrease this risk. Further, lactose (the main carbohydrate in milk and dairy products) may not affect fertility within the usual range of intake levels in humans. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/17329264/A_prospective_study_of_dairy_foods_intake_and_anovulatory_infertility_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/dem019 DB - PRIME DP - Unbound Medicine ER -