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Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task.
J Neurosci. 2007 Feb 28; 27(9):2416-23.JN

Abstract

Although it is well known that hippocampal neurons code spatial information, it is less clear how these spatial representations are influenced by memory demands, especially in hippocampus-dependent tasks. Recently, our laboratory has demonstrated that hippocampal spatial representations are influenced by mnemonic factors in a T-maze continuous alternation task. Another unique experimental approach that might reveal the ways in which task-related factors impact hippocampal spatial representations is to compare firing patterns between events that require distinct episodic memory processes. Therefore, we recorded from CA1 single neurons during a discrete trial delayed-nonmatch-to-place task that allowed within-trial comparison between an encoding (sample) phase and a retrieval (choice) phase. A large subset of neurons that fired on the central stem of the maze showed dramatic selectivity for either the sample or choice phase of the trial. However, surprisingly, there were fewer neurons that showed differential firing rates between left- and right-bound trajectories. Our results suggest that trial-phase-selective coding is common in tasks that require rapid alternation between encoding and retrieval processes.

Authors+Show Affiliations

Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA. amygriff@bu.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17329440

Citation

Griffin, Amy L., et al. "Spatial Representations of Hippocampal CA1 Neurons Are Modulated By Behavioral Context in a Hippocampus-dependent Memory Task." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, vol. 27, no. 9, 2007, pp. 2416-23.
Griffin AL, Eichenbaum H, Hasselmo ME. Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task. J Neurosci. 2007;27(9):2416-23.
Griffin, A. L., Eichenbaum, H., & Hasselmo, M. E. (2007). Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 27(9), 2416-23.
Griffin AL, Eichenbaum H, Hasselmo ME. Spatial Representations of Hippocampal CA1 Neurons Are Modulated By Behavioral Context in a Hippocampus-dependent Memory Task. J Neurosci. 2007 Feb 28;27(9):2416-23. PubMed PMID: 17329440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spatial representations of hippocampal CA1 neurons are modulated by behavioral context in a hippocampus-dependent memory task. AU - Griffin,Amy L, AU - Eichenbaum,Howard, AU - Hasselmo,Michael E, PY - 2007/3/3/pubmed PY - 2007/3/21/medline PY - 2007/3/3/entrez SP - 2416 EP - 23 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience JO - J Neurosci VL - 27 IS - 9 N2 - Although it is well known that hippocampal neurons code spatial information, it is less clear how these spatial representations are influenced by memory demands, especially in hippocampus-dependent tasks. Recently, our laboratory has demonstrated that hippocampal spatial representations are influenced by mnemonic factors in a T-maze continuous alternation task. Another unique experimental approach that might reveal the ways in which task-related factors impact hippocampal spatial representations is to compare firing patterns between events that require distinct episodic memory processes. Therefore, we recorded from CA1 single neurons during a discrete trial delayed-nonmatch-to-place task that allowed within-trial comparison between an encoding (sample) phase and a retrieval (choice) phase. A large subset of neurons that fired on the central stem of the maze showed dramatic selectivity for either the sample or choice phase of the trial. However, surprisingly, there were fewer neurons that showed differential firing rates between left- and right-bound trajectories. Our results suggest that trial-phase-selective coding is common in tasks that require rapid alternation between encoding and retrieval processes. SN - 1529-2401 UR - https://www.unboundmedicine.com/medline/citation/17329440/Spatial_representations_of_hippocampal_CA1_neurons_are_modulated_by_behavioral_context_in_a_hippocampus_dependent_memory_task_ L2 - http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=17329440 DB - PRIME DP - Unbound Medicine ER -