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Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
Clin Pharmacol Ther. 2007 May; 81(5):650-3.CP

Abstract

Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.

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Authors+Show Affiliations

Schick BA
Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada, and Research Unit, Tampere University Hospital, Finland.
Laaksonen R
No affiliation info available
Frohlich JJ
No affiliation info available
Päivä H
No affiliation info available
Lehtimäki T
No affiliation info available
Humphries KH
No affiliation info available
Côté HC
No affiliation info available

MeSH

AdultAgedAtorvastatinDNA, MitochondrialDouble-Blind MethodFemaleHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHypercholesterolemiaLongitudinal StudiesMaleMiddle AgedMitochondria, MusclePyrrolesRetrospective StudiesSimvastatinUbiquinone

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17329991

Citation

Schick, B A., et al. "Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated With High-dose Simvastatin." Clinical Pharmacology and Therapeutics, vol. 81, no. 5, 2007, pp. 650-3.
Schick BA, Laaksonen R, Frohlich JJ, et al. Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clin Pharmacol Ther. 2007;81(5):650-3.
Schick, B. A., Laaksonen, R., Frohlich, J. J., Päivä, H., Lehtimäki, T., Humphries, K. H., & Côté, H. C. (2007). Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clinical Pharmacology and Therapeutics, 81(5), 650-3.
Schick BA, et al. Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated With High-dose Simvastatin. Clin Pharmacol Ther. 2007;81(5):650-3. PubMed PMID: 17329991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. AU - Schick,B A, AU - Laaksonen,R, AU - Frohlich,J J, AU - Päivä,H, AU - Lehtimäki,T, AU - Humphries,K H, AU - Côté,H C F, Y1 - 2007/02/28/ PY - 2007/3/3/pubmed PY - 2007/5/16/medline PY - 2007/3/3/entrez SP - 650 EP - 3 JF - Clinical pharmacology and therapeutics JO - Clin Pharmacol Ther VL - 81 IS - 5 N2 - Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo. SN - 0009-9236 UR - https://www.unboundmedicine.com/medline/citation/17329991/Decreased_skeletal_muscle_mitochondrial_DNA_in_patients_treated_with_high_dose_simvastatin_ L2 - https://doi.org/10.1038/sj.clpt.6100124 DB - PRIME DP - Unbound Medicine ER -