Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.Clin Pharmacol Ther. 2007 May; 81(5):650-3.CP
Abstract
Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
Links
MeSH
Pub Type(s)
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
17329991
Citation
Schick, B A., et al. "Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated With High-dose Simvastatin." Clinical Pharmacology and Therapeutics, vol. 81, no. 5, 2007, pp. 650-3.
Schick BA, Laaksonen R, Frohlich JJ, et al. Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clin Pharmacol Ther. 2007;81(5):650-3.
Schick, B. A., Laaksonen, R., Frohlich, J. J., Päivä, H., Lehtimäki, T., Humphries, K. H., & Côté, H. C. (2007). Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin. Clinical Pharmacology and Therapeutics, 81(5), 650-3.
Schick BA, et al. Decreased Skeletal Muscle Mitochondrial DNA in Patients Treated With High-dose Simvastatin. Clin Pharmacol Ther. 2007;81(5):650-3. PubMed PMID: 17329991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Decreased skeletal muscle mitochondrial DNA in patients treated with high-dose simvastatin.
AU - Schick,B A,
AU - Laaksonen,R,
AU - Frohlich,J J,
AU - Päivä,H,
AU - Lehtimäki,T,
AU - Humphries,K H,
AU - Côté,H C F,
Y1 - 2007/02/28/
PY - 2007/3/3/pubmed
PY - 2007/5/16/medline
PY - 2007/3/3/entrez
SP - 650
EP - 3
JF - Clinical pharmacology and therapeutics
JO - Clin Pharmacol Ther
VL - 81
IS - 5
N2 - Statins are generally well tolerated, but can cause myopathy and have been associated with mitochondrial abnormalities. The aim of this study was to determine whether muscle mitochondrial DNA (mtDNA) levels are altered during statin therapy. We retrospectively quantified mtDNA in 86 skeletal muscle biopsy specimens collected as part of a previously published clinical trial of high-dose simvastatin or atorvastatin versus placebo.
SN - 0009-9236
UR - https://www.unboundmedicine.com/medline/citation/17329991/Decreased_skeletal_muscle_mitochondrial_DNA_in_patients_treated_with_high_dose_simvastatin_
L2 - https://doi.org/10.1038/sj.clpt.6100124
DB - PRIME
DP - Unbound Medicine
ER -