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The 1918 influenza pandemic: insights for the 21st century.

Abstract

The 1918-1919 H1N1 influenza pandemic was among the most deadly events in recorded human history, killing an estimated 50-100 million persons. Because recent H5N1 avian epizootics have been associated with sporadic human fatalities, concern has been raised that a new pandemic, as fatal as the pandemic of 1918, or more so, could be developing. Understanding the events and experiences of 1918 is thus of great importance. However, despite the genetic sequencing of the entire genome of the 1918 virus, many questions about the 1918 pandemic remain. In this review we address several of these questions, concerning pandemic-virus origin, unusual epidemiologic features, and the causes and demographic patterns of fatality. That none of these questions can yet be fully answered points to the need for continued pandemic vigilance, basic and applied research, and pandemic preparedness planning that emphasizes prevention, containment, and treatment with antiviral medications and hospital-based intensive care.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. dm270q@nih.gov

    Source

    The Journal of infectious diseases 195:7 2007 Apr 01 pg 1018-28

    MeSH

    Disaster Planning
    Disease Outbreaks
    Forecasting
    Genome, Viral
    Global Health
    History, 20th Century
    History, 21st Century
    Humans
    Influenza A Virus, H1N1 Subtype
    Influenza A Virus, H5N1 Subtype
    Influenza, Human

    Pub Type(s)

    Historical Article
    Journal Article

    Language

    eng

    PubMed ID

    17330793

    Citation

    Morens, David M., and Anthony S. Fauci. "The 1918 Influenza Pandemic: Insights for the 21st Century." The Journal of Infectious Diseases, vol. 195, no. 7, 2007, pp. 1018-28.
    Morens DM, Fauci AS. The 1918 influenza pandemic: insights for the 21st century. J Infect Dis. 2007;195(7):1018-28.
    Morens, D. M., & Fauci, A. S. (2007). The 1918 influenza pandemic: insights for the 21st century. The Journal of Infectious Diseases, 195(7), pp. 1018-28.
    Morens DM, Fauci AS. The 1918 Influenza Pandemic: Insights for the 21st Century. J Infect Dis. 2007 Apr 1;195(7):1018-28. PubMed PMID: 17330793.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The 1918 influenza pandemic: insights for the 21st century. AU - Morens,David M, AU - Fauci,Anthony S, Y1 - 2007/02/23/ PY - 2006/10/02/received PY - 2006/11/09/accepted PY - 2007/3/3/pubmed PY - 2007/5/2/medline PY - 2007/3/3/entrez SP - 1018 EP - 28 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 195 IS - 7 N2 - The 1918-1919 H1N1 influenza pandemic was among the most deadly events in recorded human history, killing an estimated 50-100 million persons. Because recent H5N1 avian epizootics have been associated with sporadic human fatalities, concern has been raised that a new pandemic, as fatal as the pandemic of 1918, or more so, could be developing. Understanding the events and experiences of 1918 is thus of great importance. However, despite the genetic sequencing of the entire genome of the 1918 virus, many questions about the 1918 pandemic remain. In this review we address several of these questions, concerning pandemic-virus origin, unusual epidemiologic features, and the causes and demographic patterns of fatality. That none of these questions can yet be fully answered points to the need for continued pandemic vigilance, basic and applied research, and pandemic preparedness planning that emphasizes prevention, containment, and treatment with antiviral medications and hospital-based intensive care. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/17330793/The_1918_influenza_pandemic:_insights_for_the_21st_century_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/511989 DB - PRIME DP - Unbound Medicine ER -