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Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD.
Brain Res. 2007 May 04; 1144:165-74.BR

Abstract

Functional neuroimaging studies have largely been performed in patients with longstanding chronic posttraumatic stress disorder (PTSD). Additionally, memory function of PTSD patients has been proved to be impaired. We sought to characterize the brain responses of patients with acute PTSD and implemented a trauma-related short-term memory recall paradigm. Individuals with acute severe PTSD (n=10) resulting from a mining accident and 7 men exposed to the mining accident without PTSD underwent functional magnetic resonance imaging (fMRI) while performing the symptom provocation and trauma-related short-term memory recall paradigms. During symptom provocation paradigm, PTSD subjects showed diminished responses in right anterior cingulate gyrus, left inferior frontal gyrus and bilateral middle frontal gyrus and enhanced left parahippocampal gyrus response compared with controls. During the short-term memory recall paradigm, PTSD group showed diminished responses in right inferior frontal gyrus, right middle frontal and left middle occipital gyrus in comparison with controls. PTSD group exhibited diminished right parahippocampal gyrus response during the memory recall task as compared to the symptom provocation task. Our findings suggest that neurophysiological alterations and memory performance deficit have developed in acute severe PTSD.

Authors+Show Affiliations

The Mental Health Institute, The Second Xiangya Hospital, Central South University, No. 139, Renmin Middle Road, Changsha, Hunan 410011, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17331476

Citation

Hou, Cailan, et al. "Brain Responses to Symptom Provocation and Trauma-related Short-term Memory Recall in Coal Mining Accident Survivors With Acute Severe PTSD." Brain Research, vol. 1144, 2007, pp. 165-74.
Hou C, Liu J, Wang K, et al. Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. Brain Res. 2007;1144:165-74.
Hou, C., Liu, J., Wang, K., Li, L., Liang, M., He, Z., Liu, Y., Zhang, Y., Li, W., & Jiang, T. (2007). Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. Brain Research, 1144, 165-74.
Hou C, et al. Brain Responses to Symptom Provocation and Trauma-related Short-term Memory Recall in Coal Mining Accident Survivors With Acute Severe PTSD. Brain Res. 2007 May 4;1144:165-74. PubMed PMID: 17331476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain responses to symptom provocation and trauma-related short-term memory recall in coal mining accident survivors with acute severe PTSD. AU - Hou,Cailan, AU - Liu,Jun, AU - Wang,Kun, AU - Li,Lingjiang, AU - Liang,Meng, AU - He,Zhong, AU - Liu,Yong, AU - Zhang,Yan, AU - Li,Weihui, AU - Jiang,Tianzi, Y1 - 2007/01/31/ PY - 2006/07/29/received PY - 2007/01/20/revised PY - 2007/01/23/accepted PY - 2007/3/3/pubmed PY - 2007/6/15/medline PY - 2007/3/3/entrez SP - 165 EP - 74 JF - Brain research JO - Brain Res. VL - 1144 N2 - Functional neuroimaging studies have largely been performed in patients with longstanding chronic posttraumatic stress disorder (PTSD). Additionally, memory function of PTSD patients has been proved to be impaired. We sought to characterize the brain responses of patients with acute PTSD and implemented a trauma-related short-term memory recall paradigm. Individuals with acute severe PTSD (n=10) resulting from a mining accident and 7 men exposed to the mining accident without PTSD underwent functional magnetic resonance imaging (fMRI) while performing the symptom provocation and trauma-related short-term memory recall paradigms. During symptom provocation paradigm, PTSD subjects showed diminished responses in right anterior cingulate gyrus, left inferior frontal gyrus and bilateral middle frontal gyrus and enhanced left parahippocampal gyrus response compared with controls. During the short-term memory recall paradigm, PTSD group showed diminished responses in right inferior frontal gyrus, right middle frontal and left middle occipital gyrus in comparison with controls. PTSD group exhibited diminished right parahippocampal gyrus response during the memory recall task as compared to the symptom provocation task. Our findings suggest that neurophysiological alterations and memory performance deficit have developed in acute severe PTSD. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/17331476/Brain_responses_to_symptom_provocation_and_trauma_related_short_term_memory_recall_in_coal_mining_accident_survivors_with_acute_severe_PTSD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(07)00216-8 DB - PRIME DP - Unbound Medicine ER -