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Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells.
Int J Oncol. 2007 Apr; 30(4):963-9.IJ

Abstract

Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells. Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers.

Authors+Show Affiliations

Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17332936

Citation

Thyagarajan, Anita, et al. "Combined Effect of Green Tea and Ganoderma Lucidum On Invasive Behavior of Breast Cancer Cells." International Journal of Oncology, vol. 30, no. 4, 2007, pp. 963-9.
Thyagarajan A, Zhu J, Sliva D. Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. Int J Oncol. 2007;30(4):963-9.
Thyagarajan, A., Zhu, J., & Sliva, D. (2007). Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. International Journal of Oncology, 30(4), 963-9.
Thyagarajan A, Zhu J, Sliva D. Combined Effect of Green Tea and Ganoderma Lucidum On Invasive Behavior of Breast Cancer Cells. Int J Oncol. 2007;30(4):963-9. PubMed PMID: 17332936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined effect of green tea and Ganoderma lucidum on invasive behavior of breast cancer cells. AU - Thyagarajan,Anita, AU - Zhu,Jiashi, AU - Sliva,Daniel, PY - 2007/3/3/pubmed PY - 2007/5/5/medline PY - 2007/3/3/entrez SP - 963 EP - 9 JF - International journal of oncology JO - Int J Oncol VL - 30 IS - 4 N2 - Epidemiological studies have suggested that consumption of green tea may decrease the risk of a variety of cancers. In addition, mushroom Ganoderma lucidum has been used for the promotion of health, longevity and treatment of cancer in traditional Chinese medicine. In the present study we show that extract from green tea (GTE) increased the anticancer effect of G. lucidum extract (GLE) on cell proliferation (anchorage-dependent growth) as well as colony formation (anchorage-independent growth) of breast cancer cells. This effect was mediated by the down-regulation of expression of oncogene c-myc in MDA-MB-231 cells. Although individual GTE and GLE independently inhibited adhesion, migration and invasion of MDA-MB-231 cells, their combination demonstrated a synergistic effect, which was mediated by the suppression of secretion of urokinase plasminogen activator (uPA) from breast cancer cells. Our study suggests the potential use of combined green tea and G. lucidum extracts for the suppression of growth and invasiveness of metastatic breast cancers. SN - 1019-6439 UR - https://www.unboundmedicine.com/medline/citation/17332936/Combined_effect_of_green_tea_and_Ganoderma_lucidum_on_invasive_behavior_of_breast_cancer_cells_ L2 - http://www.spandidos-publications.com/ijo/30/4/963 DB - PRIME DP - Unbound Medicine ER -