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Distinguishing between primary measles infection and vaccine failure reinfection by IgG avidity assay.
East Mediterr Health J. 2006 Nov; 12(6):775-82.EM

Abstract

In this study in the Islamic Republic of Iran 365 measles cases were evaluated to distinguish between primary infection with measles and reinfection due to secondary vaccine failure. All cases previously confirmed by detection of specific IgM were tested for IgG avidity. A secondary immune response was seen in 18.4% of patients. All unvaccinated patients (16.7%) showed a primary immune response. Of 244 patients with documented vaccination, 75.8% showed a primary immune response and 24.2% showed a secondary immune response, thereby indicating a secondary vaccine failure. Almost all measles reinfections (99%) were seen in patients >10 years old, indicating that vaccination for 10-year-old children is recommended.

Authors+Show Affiliations

Hamkar R
School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. rhamkar@sina.tums.ac.ir
Mahmoodi M
No affiliation info available
Nategh R
No affiliation info available
Jelyani KN
No affiliation info available
Eslami MB
No affiliation info available
Mohktari-Azad T
No affiliation info available

MeSH

AdolescentAdultAge DistributionAntibodies, ViralAntibody AffinityChildChild, PreschoolDiagnosis, DifferentialHealth Services Needs and DemandHumansImmunization, SecondaryImmunoenzyme TechniquesImmunoglobulin GImmunoglobulin MIranMass VaccinationMeaslesMeasles VaccineMeasles virusRecurrenceSurveys and QuestionnairesTreatment FailureUrban Health

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17333822

Citation

Hamkar, R, et al. "Distinguishing Between Primary Measles Infection and Vaccine Failure Reinfection By IgG Avidity Assay." Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, vol. 12, no. 6, 2006, pp. 775-82.
Hamkar R, Mahmoodi M, Nategh R, et al. Distinguishing between primary measles infection and vaccine failure reinfection by IgG avidity assay. East Mediterr Health J. 2006;12(6):775-82.
Hamkar, R., Mahmoodi, M., Nategh, R., Jelyani, K. N., Eslami, M. B., & Mohktari-Azad, T. (2006). Distinguishing between primary measles infection and vaccine failure reinfection by IgG avidity assay. Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, 12(6), 775-82.
Hamkar R, et al. Distinguishing Between Primary Measles Infection and Vaccine Failure Reinfection By IgG Avidity Assay. East Mediterr Health J. 2006;12(6):775-82. PubMed PMID: 17333822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distinguishing between primary measles infection and vaccine failure reinfection by IgG avidity assay. AU - Hamkar,R, AU - Mahmoodi,M, AU - Nategh,R, AU - Jelyani,K N, AU - Eslami,M B, AU - Mohktari-Azad,T, PY - 2007/3/6/pubmed PY - 2007/3/24/medline PY - 2007/3/6/entrez SP - 775 EP - 82 JF - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JO - East Mediterr Health J VL - 12 IS - 6 N2 - In this study in the Islamic Republic of Iran 365 measles cases were evaluated to distinguish between primary infection with measles and reinfection due to secondary vaccine failure. All cases previously confirmed by detection of specific IgM were tested for IgG avidity. A secondary immune response was seen in 18.4% of patients. All unvaccinated patients (16.7%) showed a primary immune response. Of 244 patients with documented vaccination, 75.8% showed a primary immune response and 24.2% showed a secondary immune response, thereby indicating a secondary vaccine failure. Almost all measles reinfections (99%) were seen in patients >10 years old, indicating that vaccination for 10-year-old children is recommended. SN - 1020-3397 UR - https://www.unboundmedicine.com/medline/citation/17333822/Distinguishing_between_primary_measles_infection_and_vaccine_failure_reinfection_by_IgG_avidity_assay_ DB - PRIME DP - Unbound Medicine ER -