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Hyperhomocysteinemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypertensive Saudi population.
Saudi Med J. 2007 Mar; 28(3):339-46.SM

Abstract

OBJECTIVE

From the emergence of different definitions of metabolic syndrome (MS) we aim to determine the prevalence of such a condition among hypertensive Saudi population and to identify which definition can best assess the risk of hyperhomocysteinemia, coronary heart disease (CHD), and diabetes mellitus.

METHODS

In this cross-sectional study, we studied 581 hypertensive Saudis, aged 21-70, at the King Abdul-Aziz University Hospital, from June 2005 to December 2005 Each participant completed the questionnaire and underwent a complete physical examination. Metabolic parameters were measured using routine laboratory procedures and homocysteine using HPLC by the electrochemical detection method.

RESULTS

According to the International Diabetes Federation (IDF) definition we diagnosed 222 males and 256 females. There is an increased risk for hyperhomocystenemia using the Adult Treatment Panel III (ATPIII) guidelines (odds ratio [OR] 3.30, 95% confidence interval [CI] 0.87-12.56; p=0.08) compared to IDF (OR 0.59, CI 0.17-2.10; p=0.41) and WHO (OR 0.45, CI 0.16-1.25; p=0.12); increased risk for probable CHD in patients with MS by WHO (OR 2.17, CI 1.11-4.25; p=0.02) compared to ATPIII (OR 2.14, CI 1.05-4.35; p=0.035) and IDF (OR 0.81, CI 0.37-1.78; p=0.6); risk of DM is highest with IDF (OR 13.07, CI 1.66-102.94; p=0.015).

CONCLUSION

There is a high prevalence of MS among hypertensive Saudis regardless of definition used; it is most prevalent using the IDF definition as well as the risk for diabetes Patients diagnosed with ATPIII guidelines have greater risk of hyperhomocysteinemia. We recommend the WHO definition for Arabs since it predicts increased risk for CHD.

Authors+Show Affiliations

College of Science Biochemistry Department, King Saud University, PO Box 2455, Riyadh 11451, Kingdom of Saudi Arabia. aldaghri2000@hotmail.com

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17334456

Citation

Al-Daghri, Nasser M.. "Hyperhomocysteinemia, Coronary Heart Disease, and Diabetes Mellitus as Predicted By Various Definitions for Metabolic Syndrome in a Hypertensive Saudi Population." Saudi Medical Journal, vol. 28, no. 3, 2007, pp. 339-46.
Al-Daghri NM. Hyperhomocysteinemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypertensive Saudi population. Saudi Med J. 2007;28(3):339-46.
Al-Daghri, N. M. (2007). Hyperhomocysteinemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypertensive Saudi population. Saudi Medical Journal, 28(3), 339-46.
Al-Daghri NM. Hyperhomocysteinemia, Coronary Heart Disease, and Diabetes Mellitus as Predicted By Various Definitions for Metabolic Syndrome in a Hypertensive Saudi Population. Saudi Med J. 2007;28(3):339-46. PubMed PMID: 17334456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperhomocysteinemia, coronary heart disease, and diabetes mellitus as predicted by various definitions for metabolic syndrome in a hypertensive Saudi population. A1 - Al-Daghri,Nasser M, PY - 2007/3/6/pubmed PY - 2007/9/12/medline PY - 2007/3/6/entrez SP - 339 EP - 46 JF - Saudi medical journal JO - Saudi Med J VL - 28 IS - 3 N2 - OBJECTIVE: From the emergence of different definitions of metabolic syndrome (MS) we aim to determine the prevalence of such a condition among hypertensive Saudi population and to identify which definition can best assess the risk of hyperhomocysteinemia, coronary heart disease (CHD), and diabetes mellitus. METHODS: In this cross-sectional study, we studied 581 hypertensive Saudis, aged 21-70, at the King Abdul-Aziz University Hospital, from June 2005 to December 2005 Each participant completed the questionnaire and underwent a complete physical examination. Metabolic parameters were measured using routine laboratory procedures and homocysteine using HPLC by the electrochemical detection method. RESULTS: According to the International Diabetes Federation (IDF) definition we diagnosed 222 males and 256 females. There is an increased risk for hyperhomocystenemia using the Adult Treatment Panel III (ATPIII) guidelines (odds ratio [OR] 3.30, 95% confidence interval [CI] 0.87-12.56; p=0.08) compared to IDF (OR 0.59, CI 0.17-2.10; p=0.41) and WHO (OR 0.45, CI 0.16-1.25; p=0.12); increased risk for probable CHD in patients with MS by WHO (OR 2.17, CI 1.11-4.25; p=0.02) compared to ATPIII (OR 2.14, CI 1.05-4.35; p=0.035) and IDF (OR 0.81, CI 0.37-1.78; p=0.6); risk of DM is highest with IDF (OR 13.07, CI 1.66-102.94; p=0.015). CONCLUSION: There is a high prevalence of MS among hypertensive Saudis regardless of definition used; it is most prevalent using the IDF definition as well as the risk for diabetes Patients diagnosed with ATPIII guidelines have greater risk of hyperhomocysteinemia. We recommend the WHO definition for Arabs since it predicts increased risk for CHD. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/17334456/Hyperhomocysteinemia_coronary_heart_disease_and_diabetes_mellitus_as_predicted_by_various_definitions_for_metabolic_syndrome_in_a_hypertensive_Saudi_population_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -