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Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies.
Diabet Med. 2007 Apr; 24(4):384-7.DM

Abstract

AIMS

To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large-for-gestational-age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits.

METHODS

We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA(1c) values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA(1c)) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates.

RESULTS

We included 209 singleton pregnancies with assessable HbA(1c) values of which 59%[95% confidence interval (CI) 52-65%] terminated with an LGA baby. Increasing levels of HbA(1c), BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA(1c) and risk of delivering an LGA baby was restricted to pregnancies with pre-pregnancy BMI > 23 kg/m(2). We found no association between HbA(1c) and risk of delivering an LGA baby in pregnancies with lower BMI.

CONCLUSION

The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m(2).

Authors+Show Affiliations

Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark. guln@rn.dkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17335464

Citation

Nielsen, G L., et al. "Maternal Glycated Haemoglobin, Pre-gestational Weight, Pregnancy Weight Gain and Risk of Large-for-gestational-age Babies: a Danish Cohort Study of 209 Singleton Type 1 Diabetic Pregnancies." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 24, no. 4, 2007, pp. 384-7.
Nielsen GL, Dethlefsen C, Møller M, et al. Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies. Diabet Med. 2007;24(4):384-7.
Nielsen, G. L., Dethlefsen, C., Møller, M., & Sørensen, H. T. (2007). Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies. Diabetic Medicine : a Journal of the British Diabetic Association, 24(4), 384-7.
Nielsen GL, et al. Maternal Glycated Haemoglobin, Pre-gestational Weight, Pregnancy Weight Gain and Risk of Large-for-gestational-age Babies: a Danish Cohort Study of 209 Singleton Type 1 Diabetic Pregnancies. Diabet Med. 2007;24(4):384-7. PubMed PMID: 17335464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal glycated haemoglobin, pre-gestational weight, pregnancy weight gain and risk of large-for-gestational-age babies: a Danish cohort study of 209 singleton Type 1 diabetic pregnancies. AU - Nielsen,G L, AU - Dethlefsen,C, AU - Møller,M, AU - Sørensen,H T, Y1 - 2007/02/28/ PY - 2007/3/6/pubmed PY - 2007/8/19/medline PY - 2007/3/6/entrez SP - 384 EP - 7 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 24 IS - 4 N2 - AIMS: To examine the association between maternal glycated haemoglobin in the second half of diabetic pregnancies and the relative risk of delivering large-for-gestational-age (LGA) babies, controlling for maternal body mass index (BMI) before pregnancy, weight gain, age, White class and smoking habits. METHODS: We identified all pregnant diabetic women in North Jutland County, Denmark from 1985 to 2003. Data on HbA(1c) values from the 20th gestational week to term were collected from medical records and the babies were classified as large, normal or small for gestational age. The association between glycated haemoglobin (HbA(1c)) and relative risk of delivering an LGA baby was quantified based on logistic regression models and stratified analysis controlling for the five covariates. RESULTS: We included 209 singleton pregnancies with assessable HbA(1c) values of which 59%[95% confidence interval (CI) 52-65%] terminated with an LGA baby. Increasing levels of HbA(1c), BMI and weight gain were all associated with increasing risk of delivering an LGA baby. Analyses stratified according to maternal BMI showed that the association between HbA(1c) and risk of delivering an LGA baby was restricted to pregnancies with pre-pregnancy BMI > 23 kg/m(2). We found no association between HbA(1c) and risk of delivering an LGA baby in pregnancies with lower BMI. CONCLUSION: The positive association between glycated haemoglobin and birth of an LGA baby seems to be restricted to women with BMI > 23 kg/m(2). SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/17335464/Maternal_glycated_haemoglobin_pre_gestational_weight_pregnancy_weight_gain_and_risk_of_large_for_gestational_age_babies:_a_Danish_cohort_study_of_209_singleton_Type_1_diabetic_pregnancies_ L2 - https://doi.org/10.1111/j.1464-5491.2007.02103.x DB - PRIME DP - Unbound Medicine ER -