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Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area.
Eur J Pharmacol. 2007 May 07; 562(1-2):92-102.EJ

Abstract

In the present study, the effects of intra-ventral tegmental area injections of cholinergic agents on morphine-induced conditioned place preference were investigated by using an unbiased 3-day schedule of place conditioning design in rats. The conditioning treatments with subcutaneous injections of morphine (0.5-7.5 mg/kg) induced a significant dose-dependent conditioned place preference for the drug-associated place. Intra-ventral tegmental area injection of an anticholinesterase, physostigmine (2.5 and 5 microg/rat) or nicotinic acetylcholine receptor agonist, nicotine (0.5 and 1 microg/rat) with an ineffective dose of morphine (0.5 mg/kg) elicited a significant conditioned place preference. Furthermore, intra-ventral tegmental area administration of muscarinic acetylcholine receptor antagonist, atropine (1-4 microg/rat) or nicotinic acetylcholine receptor antagonist, mecamylamine (5 and 7.5 microg/rat) dose-dependently inhibited the morphine (5 mg/kg)-induced place preference. Atropine or mecamylamine reversed the effect of physostigmine or nicotine on morphine response respectively. The injection of physostigmine, but not atropine, nicotine or mecamylamine, into the ventral tegmental area alone produced a significant place aversion. Moreover, intra-ventral tegmental area administration of the higher doses of physostigmine or atropine, but not nicotine or mecamylamine decreased the locomotor activity. We conclude that muscarinic and nicotinic acetylcholine receptors in the ventral tegmental area may critically mediate the rewarding effects of morphine.

Authors+Show Affiliations

School of Biology, University College of Science, University of Tehran, Tehran, Iran. rezayof@khayam.ut.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17336285

Citation

Rezayof, Ameneh, et al. "Morphine-induced Place Preference: Involvement of Cholinergic Receptors of the Ventral Tegmental Area." European Journal of Pharmacology, vol. 562, no. 1-2, 2007, pp. 92-102.
Rezayof A, Nazari-Serenjeh F, Zarrindast MR, et al. Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area. Eur J Pharmacol. 2007;562(1-2):92-102.
Rezayof, A., Nazari-Serenjeh, F., Zarrindast, M. R., Sepehri, H., & Delphi, L. (2007). Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area. European Journal of Pharmacology, 562(1-2), 92-102.
Rezayof A, et al. Morphine-induced Place Preference: Involvement of Cholinergic Receptors of the Ventral Tegmental Area. Eur J Pharmacol. 2007 May 7;562(1-2):92-102. PubMed PMID: 17336285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphine-induced place preference: involvement of cholinergic receptors of the ventral tegmental area. AU - Rezayof,Ameneh, AU - Nazari-Serenjeh,Farzaneh, AU - Zarrindast,Mohammad-Reza, AU - Sepehri,Houri, AU - Delphi,Ladan, Y1 - 2007/02/08/ PY - 2006/11/06/received PY - 2007/01/24/revised PY - 2007/01/24/accepted PY - 2007/3/6/pubmed PY - 2007/6/15/medline PY - 2007/3/6/entrez SP - 92 EP - 102 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 562 IS - 1-2 N2 - In the present study, the effects of intra-ventral tegmental area injections of cholinergic agents on morphine-induced conditioned place preference were investigated by using an unbiased 3-day schedule of place conditioning design in rats. The conditioning treatments with subcutaneous injections of morphine (0.5-7.5 mg/kg) induced a significant dose-dependent conditioned place preference for the drug-associated place. Intra-ventral tegmental area injection of an anticholinesterase, physostigmine (2.5 and 5 microg/rat) or nicotinic acetylcholine receptor agonist, nicotine (0.5 and 1 microg/rat) with an ineffective dose of morphine (0.5 mg/kg) elicited a significant conditioned place preference. Furthermore, intra-ventral tegmental area administration of muscarinic acetylcholine receptor antagonist, atropine (1-4 microg/rat) or nicotinic acetylcholine receptor antagonist, mecamylamine (5 and 7.5 microg/rat) dose-dependently inhibited the morphine (5 mg/kg)-induced place preference. Atropine or mecamylamine reversed the effect of physostigmine or nicotine on morphine response respectively. The injection of physostigmine, but not atropine, nicotine or mecamylamine, into the ventral tegmental area alone produced a significant place aversion. Moreover, intra-ventral tegmental area administration of the higher doses of physostigmine or atropine, but not nicotine or mecamylamine decreased the locomotor activity. We conclude that muscarinic and nicotinic acetylcholine receptors in the ventral tegmental area may critically mediate the rewarding effects of morphine. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/17336285/Morphine_induced_place_preference:_involvement_of_cholinergic_receptors_of_the_ventral_tegmental_area_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(07)00146-X DB - PRIME DP - Unbound Medicine ER -