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Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings.
Clin Chim Acta. 2007 May 01; 380(1-2):133-8.CC

Abstract

OBJECTIVE

Information concerning un-supplemented plasma concentrations of ubiquinol-10 in coronary artery disease patients is still controversial. The aim of this study is to determine the levels of plasma ubiquinol-10 and ratios of ubiquinol-10 to plasma lipids in consecutive patients with different angiographic findings.

SUBJECTS AND METHODS

Thirty-six consecutive patients who underwent coronary angiography were split in two groups with different atherosclerotic changes. These patients were un-supplemented with antioxidants and were not treated by lipid-lowering medication. We have measured a plasma level of ubiquinol-10 using high-performance liquid chromatography with coulometric detection. Conventional plasma lipids, markers of oxidative stress and other widely accepted risk factors of atherosclerosis have been determined too.

RESULTS

Plasma ubiquinol-10 to low-density lipoprotein cholesterol (LDL-C) ratios in patients with different angiographic findings have been found as 180+/-69 and 132+/-43, respectively (p=0.020). The ubiquinol-10/LDL-C ratio was significantly lower in angiographically positive patients. There were also significant differences in ubiquinol-10 per total cholesterol (109+/-47 and 80+/-26, respectively; p=0.031), per triglycerides (426+/-191 and 237+/-86, respectively; p=0.002) and per the sum of triglycerides and total cholesterol (86+/-35 and 61+/-20, respectively; p=0.013).

CONCLUSIONS

There have not been found any significant differences between levels of widely accepted risk factors for genesis and progress of atherosclerotic changes in these two groups of patients. Only the level of triglycerides and the total cholesterol minus high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were significantly higher in patients with stenosis. This ratio correlated with the ubiquinol-10/LDL-C ratio, which was significantly lower in patients with stenosis. Our results indicate that the ratio of ubiquinol-10/LDL-C is likely to be a risk factor for atherogenesis.

Authors+Show Affiliations

Faculty of Chemical Technology, Department of Biological and Biochemical Sciences, University of Pardubice, Strossova 239, 530 03 Pardubice, Czech Republic. pavla.zakova@upce.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17336955

Citation

Záková, Pavla, et al. "Ubiquinol-10/lipids Ratios in Consecutive Patients With Different Angiographic Findings." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 380, no. 1-2, 2007, pp. 133-8.
Záková P, Kand'ár R, Skarydová L, et al. Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings. Clin Chim Acta. 2007;380(1-2):133-8.
Záková, P., Kand'ár, R., Skarydová, L., Skalický, J., Myjavec, A., & Vojtísek, P. (2007). Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings. Clinica Chimica Acta; International Journal of Clinical Chemistry, 380(1-2), 133-8.
Záková P, et al. Ubiquinol-10/lipids Ratios in Consecutive Patients With Different Angiographic Findings. Clin Chim Acta. 2007 May 1;380(1-2):133-8. PubMed PMID: 17336955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ubiquinol-10/lipids ratios in consecutive patients with different angiographic findings. AU - Záková,Pavla, AU - Kand'ár,Roman, AU - Skarydová,Lucie, AU - Skalický,Jirí, AU - Myjavec,Andrej, AU - Vojtísek,Petr, Y1 - 2007/02/02/ PY - 2006/11/10/received PY - 2007/01/25/revised PY - 2007/01/25/accepted PY - 2007/3/6/pubmed PY - 2007/7/20/medline PY - 2007/3/6/entrez SP - 133 EP - 8 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 380 IS - 1-2 N2 - OBJECTIVE: Information concerning un-supplemented plasma concentrations of ubiquinol-10 in coronary artery disease patients is still controversial. The aim of this study is to determine the levels of plasma ubiquinol-10 and ratios of ubiquinol-10 to plasma lipids in consecutive patients with different angiographic findings. SUBJECTS AND METHODS: Thirty-six consecutive patients who underwent coronary angiography were split in two groups with different atherosclerotic changes. These patients were un-supplemented with antioxidants and were not treated by lipid-lowering medication. We have measured a plasma level of ubiquinol-10 using high-performance liquid chromatography with coulometric detection. Conventional plasma lipids, markers of oxidative stress and other widely accepted risk factors of atherosclerosis have been determined too. RESULTS: Plasma ubiquinol-10 to low-density lipoprotein cholesterol (LDL-C) ratios in patients with different angiographic findings have been found as 180+/-69 and 132+/-43, respectively (p=0.020). The ubiquinol-10/LDL-C ratio was significantly lower in angiographically positive patients. There were also significant differences in ubiquinol-10 per total cholesterol (109+/-47 and 80+/-26, respectively; p=0.031), per triglycerides (426+/-191 and 237+/-86, respectively; p=0.002) and per the sum of triglycerides and total cholesterol (86+/-35 and 61+/-20, respectively; p=0.013). CONCLUSIONS: There have not been found any significant differences between levels of widely accepted risk factors for genesis and progress of atherosclerotic changes in these two groups of patients. Only the level of triglycerides and the total cholesterol minus high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio were significantly higher in patients with stenosis. This ratio correlated with the ubiquinol-10/LDL-C ratio, which was significantly lower in patients with stenosis. Our results indicate that the ratio of ubiquinol-10/LDL-C is likely to be a risk factor for atherogenesis. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/17336955/Ubiquinol_10/lipids_ratios_in_consecutive_patients_with_different_angiographic_findings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(07)00037-X DB - PRIME DP - Unbound Medicine ER -