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Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis.
Fertil Steril. 2007 Oct; 88(4):785-8.FS

Abstract

OBJECTIVE

To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population.

DESIGN

Case-control study.

SETTING

University Department of Obstetrics and Gynecology.

PATIENT(S)

Women with (n = 239) or without (n = 287) endometriosis.

INTERVENTION(S)

The +1730 G/A polymorphism of 3'-UTR of exon 8 in the ER-beta gene was assessed by polymerase chain reaction-restriction fragment-length polymorphism analysis utilizing digestion with AluI restriction enzyme.

MAIN OUTCOME MEASURE(S)

Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.

RESULTS

The genotype distribution of the +1730 G/A polymorphism in the ER-beta gene was not different between the endometriosis patients and the controls (G/G of 74.9% vs. 72.5%, G/A of 25.1% vs. 26.1%, and A/A of 0.0% vs. 1.4%, respectively). There was also no difference in the G and A allele frequencies between the two groups (87.4% vs. 85.5%, and 12.6% vs. 14.5%, respectively). Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine stage I-II, III, IV, and III-IV, no differences were found at all in the genotype distribution or allele frequencies between the two groups.

CONCLUSION(S)

Our results suggest that the +1730 G/A polymorphism of the ER-beta gene may not be associated with the risk of endometriosis in the Korean population, which was not the case in the Japanese population.

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Authors+Show Affiliations

Lee GH
Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
Kim SH
No affiliation info available
Choi YM
No affiliation info available
Suh CS
No affiliation info available
Kim JG
No affiliation info available
Moon SY
No affiliation info available

MeSH

AdultAsian Continental Ancestry GroupCase-Control StudiesEndometriosisEstrogen Receptor betaFemaleGene FrequencyHumansKoreaPolymorphism, Genetic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17336962

Citation

Lee, Gyoung Hoon, et al. "Estrogen Receptor Beta Gene +1730 G/A Polymorphism in Women With Endometriosis." Fertility and Sterility, vol. 88, no. 4, 2007, pp. 785-8.
Lee GH, Kim SH, Choi YM, et al. Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis. Fertil Steril. 2007;88(4):785-8.
Lee, G. H., Kim, S. H., Choi, Y. M., Suh, C. S., Kim, J. G., & Moon, S. Y. (2007). Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis. Fertility and Sterility, 88(4), 785-8.
Lee GH, et al. Estrogen Receptor Beta Gene +1730 G/A Polymorphism in Women With Endometriosis. Fertil Steril. 2007;88(4):785-8. PubMed PMID: 17336962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor beta gene +1730 G/A polymorphism in women with endometriosis. AU - Lee,Gyoung Hoon, AU - Kim,Sung Hoon, AU - Choi,Young Min, AU - Suh,Chang Suk, AU - Kim,Jung Gu, AU - Moon,Shin Yong, Y1 - 2007/03/06/ PY - 2006/07/22/received PY - 2006/12/05/revised PY - 2006/12/05/accepted PY - 2007/3/6/pubmed PY - 2007/11/9/medline PY - 2007/3/6/entrez SP - 785 EP - 8 JF - Fertility and sterility JO - Fertil Steril VL - 88 IS - 4 N2 - OBJECTIVE: To investigate whether the +1730 G/A polymorphism of the estrogen receptor beta (ER-beta) gene is associated with the risk of endometriosis in a Korean population. DESIGN: Case-control study. SETTING: University Department of Obstetrics and Gynecology. PATIENT(S): Women with (n = 239) or without (n = 287) endometriosis. INTERVENTION(S): The +1730 G/A polymorphism of 3'-UTR of exon 8 in the ER-beta gene was assessed by polymerase chain reaction-restriction fragment-length polymorphism analysis utilizing digestion with AluI restriction enzyme. MAIN OUTCOME MEASURE(S): Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene. RESULTS: The genotype distribution of the +1730 G/A polymorphism in the ER-beta gene was not different between the endometriosis patients and the controls (G/G of 74.9% vs. 72.5%, G/A of 25.1% vs. 26.1%, and A/A of 0.0% vs. 1.4%, respectively). There was also no difference in the G and A allele frequencies between the two groups (87.4% vs. 85.5%, and 12.6% vs. 14.5%, respectively). Even when the endometriosis cases were subdivided into American Society for Reproductive Medicine stage I-II, III, IV, and III-IV, no differences were found at all in the genotype distribution or allele frequencies between the two groups. CONCLUSION(S): Our results suggest that the +1730 G/A polymorphism of the ER-beta gene may not be associated with the risk of endometriosis in the Korean population, which was not the case in the Japanese population. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17336962/Estrogen_receptor_beta_gene_+1730_G/A_polymorphism_in_women_with_endometriosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00061-1 DB - PRIME DP - Unbound Medicine ER -