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Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism.
Ophthalmology. 2007 Aug; 114(8):1547-51.O

Abstract

PURPOSE

To develop a new foveal hypoplasia grading system using optical coherence tomography (OCT) and to determine the correlations of visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades, respectively, in young albinism patients.

DESIGN

Observational case series.

PARTICIPANTS

Thirteen patients who were clinically diagnosed with oculocutaneous albinism.

METHODS

The authors obtained refraction and correction for participants, who then underwent anterior segment photography and fundus photography. Foveal hypoplasia was evaluated using a fast macular cross-hair scan with StratusOCT (Carl Zeiss Meditec, Dublin, CA). The authors developed a new grading system based on foveal hyporeflectivity, the degree of choroidal transillumination, the presence of the tram-tract sign, and foveal depression as determined from OCT images. Correlations of Snellen visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades were calculated, and areas under receiver operating characteristic curves (AROCs) were measured to evaluate the predictive value of foveal hypoplasia grading using OCT.

MAIN OUTCOME MEASURES

The AROCs of foveal hypoplasia grading by OCT.

RESULTS

Thirteen patients were enrolled. Correlations of visual acuity to the iris transillumination (P<0.001), macular transparency (P = 0.014), and foveal hypoplasia (P = 0.004) grades were significant. The AROC values for foveal hypoplasia measurement by OCT, iris transillumination, and macular transparency measurements were 0.98, 0.91, and 0.87, respectively.

CONCLUSIONS

The prognostic value of foveal hypoplasia as assessed by OCT in young patients with albinism is superior to grades based on iris transillumination or macular transparency.

Authors+Show Affiliations

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17337060

Citation

Seo, Je Hyun, et al. "Correlation of Visual Acuity With Foveal Hypoplasia Grading By Optical Coherence Tomography in Albinism." Ophthalmology, vol. 114, no. 8, 2007, pp. 1547-51.
Seo JH, Yu YS, Kim JH, et al. Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology. 2007;114(8):1547-51.
Seo, J. H., Yu, Y. S., Kim, J. H., Choung, H. K., Heo, J. W., & Kim, S. J. (2007). Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology, 114(8), 1547-51.
Seo JH, et al. Correlation of Visual Acuity With Foveal Hypoplasia Grading By Optical Coherence Tomography in Albinism. Ophthalmology. 2007;114(8):1547-51. PubMed PMID: 17337060.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. AU - Seo,Je Hyun, AU - Yu,Young Suk, AU - Kim,Jeong Hun, AU - Choung,Ho Kyung, AU - Heo,Jang Won, AU - Kim,Seong-Joon, Y1 - 2007/03/06/ PY - 2006/06/09/received PY - 2006/10/28/revised PY - 2006/10/30/accepted PY - 2007/3/6/pubmed PY - 2007/8/19/medline PY - 2007/3/6/entrez SP - 1547 EP - 51 JF - Ophthalmology JO - Ophthalmology VL - 114 IS - 8 N2 - PURPOSE: To develop a new foveal hypoplasia grading system using optical coherence tomography (OCT) and to determine the correlations of visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades, respectively, in young albinism patients. DESIGN: Observational case series. PARTICIPANTS: Thirteen patients who were clinically diagnosed with oculocutaneous albinism. METHODS: The authors obtained refraction and correction for participants, who then underwent anterior segment photography and fundus photography. Foveal hypoplasia was evaluated using a fast macular cross-hair scan with StratusOCT (Carl Zeiss Meditec, Dublin, CA). The authors developed a new grading system based on foveal hyporeflectivity, the degree of choroidal transillumination, the presence of the tram-tract sign, and foveal depression as determined from OCT images. Correlations of Snellen visual acuity to the iris transillumination, macular transparency, and foveal hypoplasia grades were calculated, and areas under receiver operating characteristic curves (AROCs) were measured to evaluate the predictive value of foveal hypoplasia grading using OCT. MAIN OUTCOME MEASURES: The AROCs of foveal hypoplasia grading by OCT. RESULTS: Thirteen patients were enrolled. Correlations of visual acuity to the iris transillumination (P<0.001), macular transparency (P = 0.014), and foveal hypoplasia (P = 0.004) grades were significant. The AROC values for foveal hypoplasia measurement by OCT, iris transillumination, and macular transparency measurements were 0.98, 0.91, and 0.87, respectively. CONCLUSIONS: The prognostic value of foveal hypoplasia as assessed by OCT in young patients with albinism is superior to grades based on iris transillumination or macular transparency. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/17337060/Correlation_of_visual_acuity_with_foveal_hypoplasia_grading_by_optical_coherence_tomography_in_albinism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)01561-2 DB - PRIME DP - Unbound Medicine ER -