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Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats.
Toxicology 2007; 234(1-2):44-50T

Abstract

Cadmium (Cd) is a neurotoxic metal, which induces oxidative stress and membrane disturbances in nerve system. The garlic compound diallyl tetrasulfide (DTS) has the cytoprotective and antioxidant activity against Cd induced toxicity. The present study was carried out to investigate the efficacy of DTS in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), membrane bound enzymes, lipid peroxidation (LPO) and antioxidant status in the brain of rats. In rats exposed to Cd (3mg/kg/day subcutaneously) for 3 weeks, a significant (P<0.05) increase in the levels of LPO and protein carbonyls along with significant (P<0.05) decrease in the levels of reduced glutathione (GSH) and total sulphydryl groups (TSH) and the activities of AChE, superoxide dismutase, catalase, glutathione peroxidase, gluthione-S-transeferase, membrane bound enzymes (ATPases: Na(+)K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase) were observed in brain tissue. Oral administration of DTS (40mg/kg/day) with Cd significantly (P<0.05) diminished the levels of LPO and protein carbonyls and significantly (P<0.05) increased the activities of ATPases, antioxidant enzymes, GSH and TSH in brain. These results indicate that DTS attenuate the LPO and alteration of antioxidant and membrane bound enzymes in Cd exposed rats, which suggest that DTS protects the brain function from toxic effects of Cd.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17337106

Citation

Pari, Leelavinothan, and Ponnusamy Murugavel. "Diallyl Tetrasulfide Improves Cadmium Induced Alterations of Acetylcholinesterase, ATPases and Oxidative Stress in Brain of Rats." Toxicology, vol. 234, no. 1-2, 2007, pp. 44-50.
Pari L, Murugavel P. Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology. 2007;234(1-2):44-50.
Pari, L., & Murugavel, P. (2007). Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology, 234(1-2), pp. 44-50.
Pari L, Murugavel P. Diallyl Tetrasulfide Improves Cadmium Induced Alterations of Acetylcholinesterase, ATPases and Oxidative Stress in Brain of Rats. Toxicology. 2007 May 5;234(1-2):44-50. PubMed PMID: 17337106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. AU - Pari,Leelavinothan, AU - Murugavel,Ponnusamy, Y1 - 2007/02/04/ PY - 2006/12/22/received PY - 2007/01/27/revised PY - 2007/01/30/accepted PY - 2007/3/6/pubmed PY - 2007/8/19/medline PY - 2007/3/6/entrez SP - 44 EP - 50 JF - Toxicology JO - Toxicology VL - 234 IS - 1-2 N2 - Cadmium (Cd) is a neurotoxic metal, which induces oxidative stress and membrane disturbances in nerve system. The garlic compound diallyl tetrasulfide (DTS) has the cytoprotective and antioxidant activity against Cd induced toxicity. The present study was carried out to investigate the efficacy of DTS in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), membrane bound enzymes, lipid peroxidation (LPO) and antioxidant status in the brain of rats. In rats exposed to Cd (3mg/kg/day subcutaneously) for 3 weeks, a significant (P<0.05) increase in the levels of LPO and protein carbonyls along with significant (P<0.05) decrease in the levels of reduced glutathione (GSH) and total sulphydryl groups (TSH) and the activities of AChE, superoxide dismutase, catalase, glutathione peroxidase, gluthione-S-transeferase, membrane bound enzymes (ATPases: Na(+)K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase) were observed in brain tissue. Oral administration of DTS (40mg/kg/day) with Cd significantly (P<0.05) diminished the levels of LPO and protein carbonyls and significantly (P<0.05) increased the activities of ATPases, antioxidant enzymes, GSH and TSH in brain. These results indicate that DTS attenuate the LPO and alteration of antioxidant and membrane bound enzymes in Cd exposed rats, which suggest that DTS protects the brain function from toxic effects of Cd. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17337106/Diallyl_tetrasulfide_improves_cadmium_induced_alterations_of_acetylcholinesterase_ATPases_and_oxidative_stress_in_brain_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00062-5 DB - PRIME DP - Unbound Medicine ER -