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Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats.

Abstract

Cadmium (Cd) is a neurotoxic metal, which induces oxidative stress and membrane disturbances in nerve system. The garlic compound diallyl tetrasulfide (DTS) has the cytoprotective and antioxidant activity against Cd induced toxicity. The present study was carried out to investigate the efficacy of DTS in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), membrane bound enzymes, lipid peroxidation (LPO) and antioxidant status in the brain of rats. In rats exposed to Cd (3mg/kg/day subcutaneously) for 3 weeks, a significant (P<0.05) increase in the levels of LPO and protein carbonyls along with significant (P<0.05) decrease in the levels of reduced glutathione (GSH) and total sulphydryl groups (TSH) and the activities of AChE, superoxide dismutase, catalase, glutathione peroxidase, gluthione-S-transeferase, membrane bound enzymes (ATPases: Na(+)K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase) were observed in brain tissue. Oral administration of DTS (40mg/kg/day) with Cd significantly (P<0.05) diminished the levels of LPO and protein carbonyls and significantly (P<0.05) increased the activities of ATPases, antioxidant enzymes, GSH and TSH in brain. These results indicate that DTS attenuate the LPO and alteration of antioxidant and membrane bound enzymes in Cd exposed rats, which suggest that DTS protects the brain function from toxic effects of Cd.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, India. paribalaji@gmail.com

    Source

    Toxicology 234:1-2 2007 May 05 pg 44-50

    MeSH

    Acetylcholinesterase
    Adenosine Triphosphatases
    Administration, Oral
    Allyl Compounds
    Animals
    Brain
    Brain Chemistry
    Cadmium Chloride
    Glutathione
    Injections, Subcutaneous
    Lipid Peroxidation
    Male
    Oxidative Stress
    Peroxidases
    Protein Carbonylation
    Rats
    Rats, Wistar
    Sulfhydryl Compounds
    Sulfides
    Thiobarbituric Acid Reactive Substances

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17337106

    Citation

    Pari, Leelavinothan, and Ponnusamy Murugavel. "Diallyl Tetrasulfide Improves Cadmium Induced Alterations of Acetylcholinesterase, ATPases and Oxidative Stress in Brain of Rats." Toxicology, vol. 234, no. 1-2, 2007, pp. 44-50.
    Pari L, Murugavel P. Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology. 2007;234(1-2):44-50.
    Pari, L., & Murugavel, P. (2007). Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. Toxicology, 234(1-2), pp. 44-50.
    Pari L, Murugavel P. Diallyl Tetrasulfide Improves Cadmium Induced Alterations of Acetylcholinesterase, ATPases and Oxidative Stress in Brain of Rats. Toxicology. 2007 May 5;234(1-2):44-50. PubMed PMID: 17337106.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diallyl tetrasulfide improves cadmium induced alterations of acetylcholinesterase, ATPases and oxidative stress in brain of rats. AU - Pari,Leelavinothan, AU - Murugavel,Ponnusamy, Y1 - 2007/02/04/ PY - 2006/12/22/received PY - 2007/01/27/revised PY - 2007/01/30/accepted PY - 2007/3/6/pubmed PY - 2007/8/19/medline PY - 2007/3/6/entrez SP - 44 EP - 50 JF - Toxicology JO - Toxicology VL - 234 IS - 1-2 N2 - Cadmium (Cd) is a neurotoxic metal, which induces oxidative stress and membrane disturbances in nerve system. The garlic compound diallyl tetrasulfide (DTS) has the cytoprotective and antioxidant activity against Cd induced toxicity. The present study was carried out to investigate the efficacy of DTS in protecting the Cd induced changes in the activity of acetylcholinesterase (AChE), membrane bound enzymes, lipid peroxidation (LPO) and antioxidant status in the brain of rats. In rats exposed to Cd (3mg/kg/day subcutaneously) for 3 weeks, a significant (P<0.05) increase in the levels of LPO and protein carbonyls along with significant (P<0.05) decrease in the levels of reduced glutathione (GSH) and total sulphydryl groups (TSH) and the activities of AChE, superoxide dismutase, catalase, glutathione peroxidase, gluthione-S-transeferase, membrane bound enzymes (ATPases: Na(+)K(+)-ATPase, Mg(2+)-ATPase and Ca(2+)-ATPase) were observed in brain tissue. Oral administration of DTS (40mg/kg/day) with Cd significantly (P<0.05) diminished the levels of LPO and protein carbonyls and significantly (P<0.05) increased the activities of ATPases, antioxidant enzymes, GSH and TSH in brain. These results indicate that DTS attenuate the LPO and alteration of antioxidant and membrane bound enzymes in Cd exposed rats, which suggest that DTS protects the brain function from toxic effects of Cd. SN - 0300-483X UR - https://www.unboundmedicine.com/medline/citation/17337106/Diallyl_tetrasulfide_improves_cadmium_induced_alterations_of_acetylcholinesterase_ATPases_and_oxidative_stress_in_brain_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0300-483X(07)00062-5 DB - PRIME DP - Unbound Medicine ER -