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Sun exposure and non-Hodgkin lymphoma.
Cancer Epidemiol Biomarkers Prev. 2007 Mar; 16(3):396-400.CE

Abstract

It was initially hypothesized that sun exposure might cause non-Hodgkin lymphoma (NHL) on the following grounds: its incidence was increasing in parallel with that of cutaneous melanoma; its risk was increased in those with a history of melanoma or other skin cancer; sun exposure causes immune suppression; and immunosuppression for other reasons is associated with an increased risk of NHL. The association of NHL with prior skin cancer has been found consistently in subsequent studies, but results of ecological analyses have only partially supported this hypothesis. Contrary to it, three recent studies of NHL in individuals found that risk decreased, generally by 25% to 40%, across categories of increasing total or recreational, but not occupational, sun exposure. One study, thus far reported only in abstract, showed the opposite. Production of vitamin D from sun exposure offers a plausible mechanism for protection against NHL by sun exposure. A recent study has found a reduced risk of NHL in people with a high dietary intake of vitamin D. Results of additional studies in individuals and a planned original-data meta-analysis of case-control studies should help to resolve the present conflicting results on sun exposure and NHL.

Authors+Show Affiliations

Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown 2050, Sydney, New South Wales, Australia. brucea@health.usyd.edu.auNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17337644

Citation

Armstrong, Bruce K., and Anne Kricker. "Sun Exposure and non-Hodgkin Lymphoma." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 16, no. 3, 2007, pp. 396-400.
Armstrong BK, Kricker A. Sun exposure and non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007;16(3):396-400.
Armstrong, B. K., & Kricker, A. (2007). Sun exposure and non-Hodgkin lymphoma. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 16(3), 396-400.
Armstrong BK, Kricker A. Sun Exposure and non-Hodgkin Lymphoma. Cancer Epidemiol Biomarkers Prev. 2007;16(3):396-400. PubMed PMID: 17337644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sun exposure and non-Hodgkin lymphoma. AU - Armstrong,Bruce K, AU - Kricker,Anne, Y1 - 2007/03/02/ PY - 2007/3/6/pubmed PY - 2007/5/4/medline PY - 2007/3/6/entrez SP - 396 EP - 400 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 16 IS - 3 N2 - It was initially hypothesized that sun exposure might cause non-Hodgkin lymphoma (NHL) on the following grounds: its incidence was increasing in parallel with that of cutaneous melanoma; its risk was increased in those with a history of melanoma or other skin cancer; sun exposure causes immune suppression; and immunosuppression for other reasons is associated with an increased risk of NHL. The association of NHL with prior skin cancer has been found consistently in subsequent studies, but results of ecological analyses have only partially supported this hypothesis. Contrary to it, three recent studies of NHL in individuals found that risk decreased, generally by 25% to 40%, across categories of increasing total or recreational, but not occupational, sun exposure. One study, thus far reported only in abstract, showed the opposite. Production of vitamin D from sun exposure offers a plausible mechanism for protection against NHL by sun exposure. A recent study has found a reduced risk of NHL in people with a high dietary intake of vitamin D. Results of additional studies in individuals and a planned original-data meta-analysis of case-control studies should help to resolve the present conflicting results on sun exposure and NHL. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/17337644/Sun_exposure_and_non_Hodgkin_lymphoma_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17337644 DB - PRIME DP - Unbound Medicine ER -